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All Journal Indian Journal of Forensic Medicine & Toxicology
Muneef Saab Ahmad Al-Janabi
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Public Health

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Study the Negative Effects of Pseudoephedrine on Brain Tissues in Adult Albino Male Rats Raghad Hazem Hamad Al-Abbasi; Muneef Saab Ahmad Al-Janabi; Iyad Hamid Ibrahim
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 2 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i2.15044

Abstract

In this study, (24) male animals were used, which were divided randomly into four groups. Each groupincluded (6) animals, which are: the control group that was given drinking water and food daily, and thegroup of rats treated with pseudoephedrine at a dose of (40) mg / Kg of body weight for a period of (30)days, the group of rats treated with pseudoephedrine at a dose of (40) mg / kg of body weight for a periodof (40) days, the group of rats treated with pseudoephedrine at a dose of (40) mg / kg of body weight for aperiod of (50) days, the animals dosed the drug by the oropharyngeal tube at a dose of (1) ml, and after theend of the experiment, the animals were scarified , brain samples were taken and preserved with formalinat a concentration of 10% until the tissue sections were made, when the meningeal membrane appeared theupper layers of the cerebral cortex in the group treated with pseudoephedrine for a period of 30 days wereclose to normal, while the group treated with pseudoephedrine for a period of (40) days showed shrinkagein the deep layers of the cerebral cortex and hemolysis in many blood vessels, and the meningeal membraneappeared.
Co-Authors Iyad Hamid Ibrahim Raghad Hazem Hamad Al-Abbasi