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Helmi Ismunandar
Fakultas Kedokteran Universitas Lampung
Education Medicine & Pharmacology Neuroscience Public Health

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Efek Infeksi Virus SARS-CoV-2 Pada Organ Rani Himayani; Helmi Ismunandar; Aulia Khairunnisa; Gayitri Humaera; Meilisa Hidayah Putri; Novi Jayanti
Medula Vol 11 No 1 (2021): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v11i1.178

Abstract

In December 2019, an outbreak of viral pneumonia caused by a novel coronavirus (since named SARS-CoV-2) was identified in Wuhan, China. Within few months, this disease known as coronavirus disease 2019 (COVID-19) spread worldwide, causing a global health emergency. The classic routes for transmission of SARS-CoV-2 are airborne droplets and surface contamination. The clinical presentation of COVID-19 ranges from asymptomatic infection to severe respiratory failure, with fever, fatigue, and cough occurring in most cases. The pathophysiology of SARS-CoV-2 infection is complex, endotoxin and tumor necrosis factor (TNF-α) trigger the production of interleukin (IL)-6 and IL-8, which is followed by a cytokine storm. Moreover, SARS-CoV-2 binds to angiotensin-converting enzyme-2 (ACE2) receptors, which are widely distributed not only in the lung alveolar epithelial cells and nasopharyngeal and oral mucosa but also in the endothelium and vascular smooth muscle cells, in the brain, in the gut, and in peripheral organs such as the liver and kidneys. This suggests that the clinical spectrum of COVID-19 is not limited to local pneumonia, but rather represents a multisystem illness with involvement of different organs and potential for systemic complications. Keywords:Covid-19, Angiotensin-converting enzyme, Multiple Organs.
Hubungan Indeks Massa Tubuh terhadap Volume Oksigen Maksimal (VO2max) Mahasiswa Tingkat Pertama Fakultas Kedokteran Universitas Lampung Salma Khairunnisa; Dewi Nur Fiana; Helmi Ismunandar; Khairun Nisa Berawi
Medula Vol 13 No 1 (2023): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v13i1.610

Abstract

Maximum oxygen volume (VO2max) is the maximum oxygen uptake during exercise. People with good fitness have higher VO2max value ​​and can perform activities more vigorously than those with poor fitness. Body mass index (BMI) is one of the body composition factors that affect VO2max. VO2max can be measured through various methods, one of which is the Balke test. This study aims to determine the relationship of body mass index to VO2max in the first grade students of the Faculty of Medicine, University of Lampung. This research is a correlative analytic study with a cross-sectional approach using primary data which was conducted in one meeting in November 2022. The data is obtained using measuring body mass index (BMI) first, and followed by measuring VO2max using the Balke test method. This study uses sample of 39 batch 2022 male students of the Faculty of Medicine, University of Lampung who have previously passed the inclusion and exclusion criterias. The result in this study indicates that there is a significant relationship between body mass index and VO2max in the first grade students of the Faculty of Medicine, University of Lampung. In this study, the p value is <0.001 and the correlation coefficient is -0.812, which means that there is a very strong negative correlation between variables. This negative correlation relationship indicates that the higher the body mass index (BMI) will result in lower individual VO2max values, and vice versa.
Co-Authors Aulia Khairunnisa Dewi Nur Fiana Gayitri Humaera Khairun Nisa Meilisa Hidayah Putri Novi Jayanti Rani Himayani Salma Khairunnisa