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All Journal Indian Journal of Forensic Medicine & Toxicology Journal of Global Pharma Technology
Madlen Qassm Abbas
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Medicine & Pharmacology Public Health

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Biochemical Study on the Hypoglycemic Effects of Extracted Phenolic Compounds from Grape Seeds in Streptozotocin -Induced Diabetic Rats Entedhar Rifaat Sarhat; Madlen Qassm Abbas; Gadeer Hatem Aljader; Anwar Rifaat Sarhat; Thuraia Rifaat Sarhat; Kasim Sakran Abass
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 3 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i3.15687

Abstract

Physiological Study about the Hematological Effects of Rosuvastatin and Lovastatin as Compared with Sophoretin in Rats (Rattus Norvegicus) Madlen Qassm Abbas
Journal of Global Pharma Technology Volume 10 Issue 08: (2018) August 2018
Publisher : Journal of Global Pharma Technology

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Abstract

To compare the possible hematological effects of the statins lovastatin and rosuvastatin with the flavon sophoretin, the present study was accomplished on rats. Thirty male rats allocated as five groups were used. The groups were: control, cholesterol, rosuvastatin, lovastatin and sophoretin groups. The animals of the control group were maintained on standard diet, while other groups were maintained on cholesterol diet 15mg/kg of diet and dosed orally and daily as follow: rosuvastatin 20 mg/kg body weight, lovastatin 4 mg, and sophoretin20 mg respectively. The study comprised some hematological parameters including red cells count, hemoglobin concentration, leukocytes count, hematocrit, differential leukocyte count, platelets count, red cells indices, and platelets indices. The results showed that cholesterol caused a significant increase in red cells count (RBC), hemoglobin (HGB), and hematocrit (HCT) with a significant decrease in total white cells count (WBC) and platelets count (PLT). Rosuvastatin caused a significant decrease in HGB, HCT and WBC while lovastatin caused a significant decrease in WBC, and PLT. For sophoretin, all the parameters were without significant differences as compared with control group at (P≤0.05). Considering other blood indices, they are more detailed in the results.Keywords: Sophoretin, Quercetin, Rosuvastatin, Lovastatin, Rats.
Co-Authors Anwar Rifaat Sarhat Entedhar Rifaat Sarhat Gadeer Hatem Aljader Kasim Sakran Abass Thuraia Rifaat Sarhat