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All Journal Medula ARTERI : Jurnal Ilmu Kesehatan JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia
Neema Putri Prameswari
Universitas Lampung
Education Electrical & Electronics Engineering Health Professions Medicine & Pharmacology Neuroscience Nursing Public Health

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Vasopressin pada Manajemen Syok Septik Iswandi Darwis; Rizka Humardewayanti Asdie; Neema Putri Prameswari
Medula Vol 11 No 3 (2021): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v11i3.288

Abstract

Sepsis is a systemic inflammatory response caused by an infection, which can involve multiple organs. Sepsis and multiple organ dysfunction syndrome (MODS) are the main causes of death in the intensive care unit of a hospital. In sepsis, septic shock, defined as sepsis-induced persistent hypotension despite adequate fluid resuscitation causing tissue hypoperfusion, can occur. Norepinephrine and dopamine are the vasopressors of choice for initial treatment septic shock, but the use of high-dose catecholamine vasopressors can cause adrenergic side effects that can increase mortality. Therefore, a septic shock patient with increased heart rate, it is necessary to use a vasopressor that does not cause adrenergic side effects. Vasopressin is a hormone secreted by the posterior pituitary. In hypotensive condition, vasopressin physiologically helps maintain blood pressure by acting as a potent vasoconstrictor. Vasopressin administration does not cause side effects caused by adrenergic stimulation such as increased tissue oxygen demand, decreased renal and mesenteric flow, increased pulmonary resistance and arrhythmias. This literature review also discusses the effects of vasopressin on blood pressure, the cardiovascular system, the immune system, the coagulation system, the respiratory system, the urinary system and the central nervous system in patients with septic shock.
Wanita Usia 39 Tahun dengan Ensefalopati Hipertensi: Laporan Kasus Neema Putri Prameswari; Vioren; Anisa Ramadhanti; Zam Zanariah Ibrahim
ARTERI : Jurnal Ilmu Kesehatan Vol 3 No 3 (2022): Mei
Publisher : Puslitbang Sinergis Asa Professional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37148/arteri.v3i3.214

Abstract

Hypertensive encephalopathy is an acute reversible syndrome caused by a sudden increase of blood pressure so crosses the limits of brain auto-regulation. The objective of writing this scientific paper was to present clinical manifestations of hypertensive encephalopathy and report the favorable clinical outcomes in hypertensive encephalopathy patients with comprehensive therapy. This paper is an empirical case study investigates the symptoms of Hypertensive Encephalopathy in real life. Female, 39 years old complaints of sudden seizures, before the seizure she felt of non-throbbing headache all over her head. There was an increase in blood pressure of 200/130 mmHg. On neurologic-ophthalmologic examination, her right eye had no light perception (NLP), while on other neurological functions there were no abnormalities. She was hospitalized and treated with antihypertensive drugs, that are Amlodipine and Lamipril, during inpatient the DASH diet was given. The patient showed improvement, then was discharged on the 5th day of treatment. Diagnosis of hypertensive encephalopathy was made in this patient built upon high blood pressure plus neurologic symptoms and the exclusion of other conditions that could cause similar symptoms. Antihypertensives were used carefully at a target blood pressure of 150/100 mmHg (20% of MAP). Application of DASH diet has an effect for lowering blood pressure due to the restriction of sodium intake from food. Management of hypertensive encephalopathy includes lowering blood pressure but it’s not recommended aggressively because it can cause ischemia. Preventive measures are very important, research is needed on predictive factors for hypertension encephalopathy and a high level of alertness in risk groups.
PEMANFAATAN SENYAWA ANTIATEROGENIK JAMUR TIRAM PUTIH (PLEUROTUS SPP.) DALAM PENCEGAHAN ATEROSKLEROSIS Neema Putri Prameswari
JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Vol 7 No 2 (2019): JIMKI : Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Volume 7.2 Edisi Mei - Oktob
Publisher : BAPIN-ISMKI (Badan Analisis Pengembangan Ilmiah Nasional - Ikatan Senat Mahasiswa Kedokteran Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53366/jimki.v7i2.65

Abstract

Pendahuluan: Aterosklerosis merupakan kondisi yang disebabkan oleh proses inflamasi kronis yang menyebabkan pembentukan plak pembuluh darah. Terjadinya aterosklerosis diakibatkan oleh beberapa faktor seperti hiperkolestrolemia, stress oksidatif, dan hipertensi. Aterosklerosis yang terjadi pada pembuluh darah dapat menyebabkan Penyakit Jantung Koroner (PJK) yang juga mampu menyebabkan kematian. Jamur tiram putih (Pleurotus spp.), yang bisa dengan mudah ditemukan di Indonesia, dinilai memiliki kandungan bioaktif yang mampu mencegah aterosklerosis. Tujuan: untuk mengetahui potensi dan pemanfaatan jamur tiram putih (Pleurotus spp.) dalam pencegahan aterosklerosis melalui penurunan kadar profil lipid aterogenik. Metode: artikel dibuat dengan metode literature review, melibatkan 16 pustaka baik buku dan jurnal nasional atau internasional. Hasil: Jamur tiram putih (Pleurotus spp.) mengandung senyawa bioaktif bersifat antiaterogenik yaitu lovastatin. Senyawa lovastatin yang terkandung dalam jamur tiram putih terbukti dapat menurunkan kadar kolesterol total trigliserida, dan low density lipoprotein (LDL). Pembahasan: Kemampuan jamur tiram putih untuk mencegah terjadinya aterosklerosis disebabkan kandungan lovastatin yang dimilikinya. Mekanisme kerja lovastatin dalam mencegah aterosklerosis yaitu menurunkan profil lipid aterogenik dengan menghambat kerja enzim 3-hidroksi-3-metilglutaril koenzim A (HMG-KoA) reduktase sehingga mampu menghambat proses biosintesis kolesterol. Simpulan: Jamur tiram putih (Pleurotus spp.) dapat menjadi alternatif yang mudah didapat, murah, dan mudah dalam mencegah terjadinya aterosklerosis.
Co-Authors Anisa Ramadhanti Iswandi Darwis Rizka Humardewayanti Asdie Vioren Zam Zanariah Ibrahim