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Pengaruh Bawang Putih Tunggal (Allium Sativum L) pada Aterosklerosis Angie Carolyn; agustyas tjiptaningrum; anggraini janar wulan
Medula Vol 11 No 4 (2021): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v11i4.301

Abstract

Atherosclerosis is characterized by changes in the size of arteries caused by the formation of atherosclerosis plaques consisting of necrosis cells, calcified areas, modified lipid accumulation, smooth muscle cells, endothelial cells, leukocytes, and foam cells. Coronary Artery Disease and stroke are the main clinical manifestations of atherosclerosis. One of the causes of aeroskelrosis is consuming too much food that contains high fat. The interaction between oxidized LDL and the walls of blood vessels, can cause endothelium dysfunction. In addition, oxidized LDL stimulates the formation of lipid peroxide free radicals, makes mononuclear cells (monocytes) differentiate into macrophages, then begins inflammation by removing pro-inflammatory cytokines. Single Clove Garlic (SGC) is a tropical plant found in Indonesia and is often used as an herbal remedy. Single Clove Garlic is a variation of garlic that is formed accidentally, due to extreme conditions. This type of onion contains Alliin (411.4 mg/mL), Allicin (268.2 mg/mL) and ajoene which makes it have a higher antioxidant capacity than regular garlic.  The use of SGC as quoted is considered to be beneficial for the cardiovascular system.
PENGARUH EKTRAK KULIT MANGIS (Gracinia mangostan L.) TERHADAP JUMLAH RERATA SPERMATOSIT PRIMER TIKUS PUTIH JANTAN (Rattus Novergicus) Galur Spragua dawley YANG DIINDUKSI PLUMBUM ASETAT I gede sugiana Karaeng; anggraini janar wulan; Hendri Busman
Medula Vol 11 No 4 (2021): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v11i4.302

Abstract

The Pb metal content in motor vehicle exhaust gases can danger health and  damage the environment. Pb metal as a free radical can trigger oxidative stress. Oxidative stress causes an increase in reactive oxygen species (ROS) and damage to the spermatozoa membrane. Antioxidants are one of the compounds that can be used to overcome this problem, including the mangosteen peel extract which has a view of antioxidants as an antidote to free radicals. This experimental was conducted for 14 days. 25 male rats (Spragua dawley) were divided into 5 treatment groups: K + (without treatment), K-, P1, P2, P3 (exposed to plumbum acetate dose of 0.35gram / KgBB and given consecutively mangosteen peel extract at a dose of 0 , 50, 100, 200 mg / KgBB, mean primary sprematocytes were calculated using a microscope with 400x magnification. The results of the treatment analysis (P1, P2, and P3) showed that the mangosteen peel extract had not been able to increase mean primary spematocytes from male white rats, mean that of primary spermatocytes obtained was 133.2 ± 24 (K+), 71.85 ± 16.9 (K-), 72.0 ± 17.3 (P1), 29.2 ± 9.3 (P2), 43.3 ± 6.82 (P3)test post hoc LSD showed significant differences from each treatment group. The extract of the Mangosteen skin was not yet able to increase Average of primary spermatocytes of male white rats exposed to plumbum acetate.
Co-Authors agustyas tjiptaningrum Angie Carolyn Hendri Busman I gede sugiana Karaeng