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All Journal Indian Journal of Forensic Medicine & Toxicology JK Jurnal Kesehatan
Cynthia Wahyu Asrizal
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Health Professions Immunology & microbiology Neuroscience Nursing Public Health

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Effects of Monosodium Glutamate (MSG) on Neuron Damages in Hippocampus in Sprague-Dawley rats Rezania Razali; Zulkarnain Zulkarnain; Cynthia Wahyu Asrizal
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 3 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i3.15915

Abstract

Introduction: Monosodium glutamate (MSG) is a flavor enhancer commonly used worldwide. Studies haveshown that high dose of MSG could act as neurotoxic or excitotoxic agent for neurons in the central nervoussystem. The aim of this study was to determine the effect of MSG on neuron changes of hippocampusanimalmodel.Materials and Methods: A total of 25 white male Sprague-Dawleyrats, aged 8-10 weeks,were dividedinto5 groups (2 control groups (i.e., none and solvent group) and3 treatment groups that received2, 4and 6 mg/gram MSG orallyfor 30 days). Afterfour weeks on treatment, all animals were sacrificed and the entire braintissueswere removed and immediately fixed in formalin for hematoxylin and eosin (H&E) staining.Results:The percentage of damaged neurons in three Cornuammonisareas of hippocampus was higher inanimal supplemented with MSG compared to controls. At the highest MSG concentration (6 mg/gram),52.1%, 55.2% and 66.0% of neurons from Cornuammonis 1, 2, and 3, respectively were damaged. Thepercentage of neuron damages in hippocampus was in dose-dependent manner.Conclusion: Our data suggested that high dose of MSG increased thehippocampus neuron damages in dosedependenteffect. This suggests the neurotoxicity effect of high dose of MSG.
PERAN VITAMIN D PADA PROSES PENUAAN KULIT DAN SISTEM SARAF Cynthia Wahyu Asrizal; Fitra Fitra
Jurnal Kesehatan Vol. 2 No. 6 (2024): Juni
Publisher : CV. ADIBA AISHA AMIRA

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Abstract

Vitamin D, which is actually a hormone, plays a role in various organs of the body. Vitamin D comes from food intake and from the skin when exposed to UVB rays. This vitamin D is then converted into the active form 1,25(OH)2D3 or calcitriol. Calcitriol has a vitamin D receptor (VDR) which is spread across various organs including the skin and nerves. Therefore, vitamin D plays a role in the physiological processes in these organs. Age, lifestyle and external exposure can affect the aging process. Deficiency or insufficiency of vitamin D can disrupt the physiological processes of organs and cause various pathological conditions including the aging process of the skin and nerves. This article reviews the role of vitamin D in the physiological processes in the skin and nerves and its role in the aging process of the skin and nerves.
Co-Authors Fitra Fitra Rezania Razali Zulkarnain Zulkarnain