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All Journal Indian Journal of Forensic Medicine & Toxicology
Mohammed Hamid Mohammed
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Public Health

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Rationale and Dose Regimen for Sitagliptin/ Glimepiride Combination Therapy in Type 2 Diabetes Treatment Mohammed Hamid Mohammed; Orooba Mohammed Saeed Ibrahim
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 3 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i3.15981

Abstract

This study explores how glimepiride, alone or in combination with sitagliptin, affected glycemic control inType 2 diabetes patients. Type 2 diabetes was induced in rats by feeding them a high-fat diet and injectingthem with Alloxan and nicotinamide. Forty-two rats were divided equally into seven groups. Negativecontrol and group 2-7: rats fed with the HFD Positive control (diabetic non-treated) Group (T1, T2, T3, T4and T5) were treated with monotherapy and combination. All the treatment regimen reduces fasting bloodglucose and enhanced GLP-1 and insulin level as indicated by an increase in the area under the curve.Additionally, as opposed to monotherapies, the combination category had better glycemic regulation. As aresult, we assume that sitagliptin/glimepiride combined therapy has a synergistic effect.
Co-Authors Orooba Mohammed Saeed Ibrahim