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All Journal Indian Journal of Forensic Medicine & Toxicology
Hind Chassab Karam
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Public Health

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Effects of Contraception Pills and Hormone Replacement Therapy on Tissue Plasminogen Activator -1 and Plasminogen Activator Inhibitor-1 in Per and Postmenopausal Women Hind Chassab Karam; Dakhel Ghani Omran
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 3 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i3.16248

Abstract

Contraception is a program employed to avoid pregnancy during premenopausal period where as hormonereplacement therapy (HRT) is a medical option to ameliorate menopausal complications. The present studywas designed to evaluate the effects of contraceptions and HRT on estradiol hormone ,tissue plasminogenactivator-1 (TPA-1),and plasminogen activator in hibitor-1(PAI-1).One hundred (120) women were recruited ;30 women with contraception; 30 women with HRT ,and60women contraception ; with HRT , and 60 women as a control group. All ages of women were rangedbetween 31-70 years old and subdivided into four groups(31-40,41-50, 51-60, 61-70 years old ).Data obtained from this study indicated a significant elevation (p<0.05) in the levels of estradiol hormone inall tested groups of women compared to control women (without contraception and HRT).It was establisheda significant drop (p<0.05) in the concentration of TPA-1 in women taking contraception and those intakeHRT in a comparison with control groups. About levels of PAI-1,they were significantly higher (p<0.05)in both women with contraception and HRT than of control women .From these observations the availableconclusion may be administration of contraception and HRT influence fibrinolytic system and increaseincidence of thrombotic events .
Co-Authors Dakhel Ghani Omran