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Niken Pratiwi Liambo
Fakultas Farmasi Universitas Muslim Indonesia
Biochemistry, Genetics & Molecular Biology Chemistry Medicine & Pharmacology

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UJI ANTIMITOSIS EKSTRAK ETANOLIK KLIKA SIRSAK (Annona muricata L.) TERHADAP SEL TELUR LANDAK LAUT (Tripneustes gratilla L.) TERFERTILISASI Niken Pratiwi Liambo; Abd. Malik; Aktsar Roskiana Ahmad
Jurnal Fitofarmaka Indonesia Vol 3, No 2 (2016): JURNAL FITOFARMAKA INDONESIA
Publisher : Faculty of Pharmacy, Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (934 KB) | DOI: 10.33096/jffi.v3i2.218

Abstract

Soursop belongs to Annonaceae family. In the traditional medicine has been as anticancer, antivirus, wound healing, lowering uric acid levels. This study aims to determine the IC80value extract ethanolic of soursop bark to sea urchin egg (Tripneustes gratilla L.) fertilized. Dryed sample extracted by maceration method using ethanol solvent. Retrieved rendamen extract as much as 2,525 %. Based on qualitative test chemical components that extract ethanolic of soursop bark contain   tannins, saponins, alkaloids and flavonoids. Antimitotic test conducted on extract ethanolic of soursop bark (A.muricata) obtained by looking at the sea urchin egg cell inhibition (Tripneustes gratilla L.) to calculate IC80 values by probit analysis method. Antimitotic test results showed that the extract ethanolic of soursop bark (A.muricata) as an antimitotic active with IC80 values of 1,56 x 10-3 mg/ml. Although the potential is lower than that of vincristine inhibit 80 % of eggs fertilized with Tripneustes gratilla L. IC80value is 7,046 x 10-7 mg/ml.
Co-Authors Ahmad, Aktsar Roskiana