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Trully D. Sitorus
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Medicine & Pharmacology

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The Teratogenic Effect of The Mindi (Melia azedarach L) Leaves Ethanol Extract on Mice (Mus musculus) Fetus Adisti Erlina Sutomo; Trully D. Sitorus; Adhi Pribadi
Althea Medical Journal Vol 2, No 2 (2015)
Publisher : Faculty of Medicine Universitas Padjadjaran

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Background: Mindi leaves (Melia azeradach L.) were used by Indonesians as a traditional medicine for pregnant women because it was considered to be safe. Mindi leaves contain several active compounds and one of them is suspected as a teratogen and can disrupt fetus growth in gestation. This research aims to know about the teratogenic effect of ethanol extract of Mindi leaves by using mice.Methods: This was a laboratory experimental study using 27 pregnant female mice (Mus musculus) of Swiss Webster strain which were randomly assigned to 3 groups (n=9) controlled (Carboxymethyl cellulose 1% for day 1–18 of pregnancy), group I (mindi leaves ethanol extract 3.22 mg+Carboxymethyl cellulose 1% day 1–5 of pregnancy), and group II (mindi leaves ethanol extract 3.22 mg+Carboxymethyl cellulose 1% day 6–18 of pregnancy). Observation was done to see total amount of fetus, live normal fetus count, length and weight of fetus, abnormal fetus count consisting of dead fetus count with normal and abnormal external morphology, and resorbed fetus count. This research was done from October to November 2012 in Pharmacological laboratory of Faculty of Medicine Universitas Padjajdjaran. Data analysis utilized unpaired t-test.Results: The result showed a significant difference (p<0.05), seen from live normal fetus count and abnormal fetus count consisting of dead fetus count with normal and abnormal external morphology, and resorpted fetus count. Conclusions: Administration of Mindi leaves extract during pregnancy of mices can cause teratogenic effect.[AMJ.2015;2(1):221–25]
Effect of Centella asiatica Leaves on Gastric Ulcer in Rats Ester Mariska; Trully D. Sitorus; Januarsih A. Rachman
Althea Medical Journal Vol 2, No 1 (2015)
Publisher : Faculty of Medicine Universitas Padjadjaran

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  Background: Gastric ulcer is disruption of gastric mucosal integrity due to lack of smaller defensive factors (e.g. mucus levels) than gastric aggressive factors. Centella asiatica is a traditional medicine that contains triterpenoids and flavonoids. The objective of this study was to analyze the effect of ethanol extract of Centell aasiatica leaves for preventing gastric mucus level reduction of aspirin-induced gastric ulcer model in rats and compared it to misoprostol.Methods: An experimental laboratory study using 24 rats that were divided into 4 groups. Group I (negative control) received carboxymethy cellulose (CMC) solution, group II (positive control) received CMC and aspirin 450mg/kg, group III (tested group) received Centella asiatica 400 mg/kg and aspirin 450 mg/kg, group IV (compared group) received misoprostol 72μg/kg and aspirin 450mg/kg for three days. Then the rats were laparatomied and their gastric mucus levels were measured. The results were statistically analyzed by Independent T-test.Results: The mean levels of gastric mucus of group I, II, III, IV, respectively were 0.112; 0.035; 0.537; 0.455 optical densities per gram of tissue. The statistical test suggested a significant difference between the positive control group and tested group. Moreover there is no significant difference between the tested group and compared group.Conclusions: Centella asiatica leaves can prevent gastric mucus level reduction of aspirin-induced gastric ulcer model in rats and has similar effect in gastric mucus level with misoprostol.Keywords: Centella asiatica, gastric mucus, gastric ulcer, misoprostolDOI: 10.15850/amj.v2n1.444 
Green Tea and its Effect on Hemostasis Measured by Thrombelastography Bryant Alyzandyr Eumhyn Chua; Trully D. Sitorus; Nadjwa Zamalek Dalimoenthe
Althea Medical Journal Vol 2, No 1 (2015)
Publisher : Faculty of Medicine Universitas Padjadjaran

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Abstract

Background: Increasing health problems may come from changes in lifestyle including stressful lifestyles, high calorie diets, and lack of physical activity. Those may also lead to an increase occurrence of abnormal hemostasis. Green tea has been well known for its many benefits, including its antithrombotic effect. The aim of this study was to determine whether the consumption of green tea actually affects hemostasis and to measure changes in hemostatic parameters after its consumption.Methods: A preliminary explorative study was conducted on 3 healthy female subjects aged between 21 to 22 years old for 8 weeks from October to November 2012 in Jatinangor, Sumedang, Indonesia. The subjects were subjected to initial thrombelastography analysis and started drinking green tea twice a day after meals. The solution was made by steeping a teabag in 250ml water of 70°C for 2 minutes. After 8 weeks, another thrombelastography analysis was performed to the subjects. Results: Pre- and post-intervention results of the analysis were averaged and compared according to the parameters. The results of this study showed prolonged R (Reaction-time) and K (K-time), decreased α (angle) and MA (Maximum Amplitude), and increased LY30 (lysis at 30 minutes), showing an overall reduction in coagulability. Conclusions: The consumption of green tea twice a day for 8 weeks affects hemostasis with hemostatic parameters measured by thrombelastography show differences before and after consumption.Keywords: Green tea, hemostasis, thrombelastographyDOI: 10.15850/amj.v2n1.426
Co-Authors Adhi Pribadi Adisti Erlina Sutomo Bryant Alyzandyr Eumhyn Chua Ester Mariska Januarsih A. Rachman Nadjwa Zamalek Dalimoenthe