Nadjwa Zamalek Dalimoenthe
Departemen Patologi Klinik Fakultas Kedokteran Universitas Padjadjaran/Rumah Sakit Umum Pusat Dr. Hasan Sadikin, Bandung

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Green Tea and its Effect on Hemostasis Measured by Thrombelastography Chua, Bryant Alyzandyr Eumhyn; Sitorus, Trully D.; Dalimoenthe, Nadjwa Zamalek
Althea Medical Journal Vol 2, No 1 (2015)
Publisher : Althea Medical Journal

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (620.611 KB)

Abstract

Background: Increasing health problems may come from changes in lifestyle including stressful lifestyles, high calorie diets, and lack of physical activity. Those may also lead to an increase occurrence of abnormal hemostasis. Green tea has been well known for its many benefits, including its antithrombotic effect. The aim of this study was to determine whether the consumption of green tea actually affects hemostasis and to measure changes in hemostatic parameters after its consumption.Methods: A preliminary explorative study was conducted on 3 healthy female subjects aged between 21 to 22 years old for 8 weeks from October to November 2012 in Jatinangor, Sumedang, Indonesia. The subjects were subjected to initial thrombelastography analysis and started drinking green tea twice a day after meals. The solution was made by steeping a teabag in 250ml water of 70°C for 2 minutes. After 8 weeks, another thrombelastography analysis was performed to the subjects. Results: Pre- and post-intervention results of the analysis were averaged and compared according to the parameters. The results of this study showed prolonged R (Reaction-time) and K (K-time), decreased α (angle) and MA (Maximum Amplitude), and increased LY30 (lysis at 30 minutes), showing an overall reduction in coagulability. Conclusions: The consumption of green tea twice a day for 8 weeks affects hemostasis with hemostatic parameters measured by thrombelastography show differences before and after consumption.Keywords: Green tea, hemostasis, thrombelastographyDOI: 10.15850/amj.v2n1.426
Profile of Anemia on Lung Tuberculosis at Dr. Hasan Sadikin General Hospital and Community Lung Health Center Bandung Adzani, Marizka; Dalimoenthe, Nadjwa Zamalek; Wijaya, Indra
Althea Medical Journal Vol 3, No 1 (2016)
Publisher : Althea Medical Journal

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Abstract

Background: Tuberculosis (TB) is a chronic infectious disease caused by Mycobacterium tuberculosis that can cause anemia. Anemia is a lack of erythrocyte mass needed to carry adequate oxygen to the whole bodies. The aim of this study was to describe the anemia in adult lung TB patients at Dr. Hasan Sadikin General Hospital and Community Lung Health Center (Balai Kesehatan Paru Masyarakat, BKPM) Bandung.Methods: This descriptive study was conducted from August to October 2014. Study subjects were adult TB patients who came for their first control to TB Clinic Dr. Hasan Sadikin General Hospital and BKPM Bandung after receiving oral antituberculosis drugs, and willing to comply in study. The exclusion criteria were patients with other chronic diseases, pregnant, menorrhagia, and hemoptoe. Three mL of vein blood was taken and put into EDTA tube for routine hematologic measurement using automatic hematologic analyzer, sysmex KX-21®.Results: There was 31 (63.26%) from 49 adult lung TB patients suffered anemia. In male subjects, mild and moderate anemia were found 57.14% and 42.86% respectively, and in female subjects were 58.82% and 41.18% respectively. In males, there were 42.86% normochromic normocytic, 42.86% hypochromic microcytic, 7.14% normochromic microcytic, and 7.14% hypochromic normocytic, while in females, there were 5.88% normochromic normocytic, 47.06% hypochromic microcytic, 17.65% normochromic microcytic, 29.41% hypochromic normocytic.Conclusions: Anemia is found in 63.26% adult lung TB patients, most of which are mild anemia and hypochromic microcytic, especially in female subjects. [AMJ.2016;3(1):137–40] DOI: 10.15850/amj.v3n1.473
SKRINING THALASSEMIA BETA MINOR PADA SISWA SMA DI JATINANGOR alyumnah, putri; Ghozali, Mohammad; Dalimoenthe, Nadjwa Zamalek
Jurnal Sistem Kesehatan Vol 1, No 3 (2016): Volume 1 Nomor 3 Maret 2016
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (238.88 KB) | DOI: 10.24198/jsk.v1i3.10358

Abstract

Jenis Thalassemia yang paling banyak ditemukan adalah Thalassemia beta. Tercatat 10% penduduk Indonesia merupakan pembawa gen Thalassemia beta. Thalassemia beta minor sulit dideteksi karena bersifat asimtomatik sehingga peranan skrining sebagai deteksi dini sangat diperlukan. Sampai dengan saat ini di Indonesia belum dilakukan program skrining rutin Thalassemia.Tujuan penelitian ini untuk mengetahui frekuensi Thalassemia beta minor pada siswa- siswi SMA di Jatinangor. Metode Penelitan deskriptif kuantitatif, dengan teknik pengambilan data cross sectional telah dilakukan sejak bulan September sampai dengan Oktober 2015. Subyek penelitian terdiri dari siswa-siswi di 5 SMA kelas 10 dan 11 yang terregistrasi di Jatinangor. Hasil Dari seluruh siswa-siswi kelas 10 dan 11 SMA di Jatinangor, hanya ada 292 yang hadir saat penyuluhan, dan hanya 130 orang di antaranya yang bersedia mengikuti penelitian. Pada penelitian ini ditemukan 12 (9,3%) orang sebagai thalassemia beta minor. Pembahasan pada penelitian ini ditemukan 12 (9,3%) orang sebagai thalassemia beta minor. Pada penelitian lain di Banyumas didapatkan 8%.Kata kunci: Skrining,Thalassemia,Thalassemia beta minor
Perbandingan Derajat Hiperemis Pascabedah Pterigium Inflamasi antara Teknik Lem Fibrin Otologus dan Teknik Jahitan Rifada, Maula; Prawirakoesoema, Loekman; Dalimoenthe, Nadjwa Zamalek; Enus, Sutarya
Majalah Kedokteran Bandung Vol 45, No 3 (2013)
Publisher : Faculty of Medicine, Universitas Padjadjaran

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Abstract

Tandur konjungtiva bulbi merupakan baku emas pada pembedahan pterigium yang secara umum metode penempelannya dengan menggunakan jahitan, namun memiliki beberapa kekurangan, di antaranya waktu pembedahan cukup lama, menimbulkan reaksi inflamasi, dan kemungkinan komplikasi. Saat ini dikembangkan penggunaan lem fibrin untuk penempelan tandur konjungtiva bulbi sebagai alternatif prosedur pengganti jahitan. Penelitian ini bertujuan untuk mengetahui derajat hiperemis pascabedah pterigium inflamasi antara teknik lem fibrin otologus (LFO) dan teknik jahitan. Penelitian ini merupakan uji klinis acak terkontrol tersamar tunggal yang dilaksanakan di Pusat Mata Nasional Rumah Sakit Mata Cicendo Bandung dari bulan Oktober−Desember 2010. Subjek penelitian dibagi menjadi dua kelompok secara acak dan hasilnya terdapat 12 penderita kelompok LFO dan 14 penderita kelompok jahitan. Pemantauan dilakukan pada minggu pertama, kedua, dan keempat pascabedah serta dilakukan pengambilan foto lampu celah biomikroskop digital. Benang jahitan disamarkan menggunakan perangkat lunak penyunting foto dan satu orang pengamat menilai secara objektif derajat hiperemis pada foto digital. Analisis statistik dilakukan menggunakan Uji Mann Whitney. Hasil penelitian menunjukkan bahwa derajat hiperemis secara bermakna lebih kecil pada minggu pertama, kedua, dan keempat pada kelompok teknik LFO (derajat hiperemis 2,5; 2; dan 1,5) dibandingkan dengan kelompok teknik jahitan (derajat hiperemis 4; 3; dan 2) (p<0,05). Simpulan, penggunaan LFO untuk melekatkan tandur konjungtiva bulbi pada pembedahan pterigium inflamasi menghasilkan derajat hiperemis yang lebih kecil dibandingkan dengan penggunaan jahitan. [MKB. 2013;45(3):174–9]Kata kunci: Lem fibrin otologus, pterigium inflamasi Comparison of Hyperemia Degree between Autologous Fibrin Glue and Suture Technique Post Inflammed Pterygium SurgeryConjunctival autograft is the gold standard in pterygium surgery which is regularly secured with suture, butthis method has few drawbacks of prolonged operating time, provoke ocular inflammation and potential risk for suture related complication. The use of fibrin glue has become an alternative procedure in conjuntival graft transplantation. The aim of this study was to compare hyperemia degree post inflamed pterygium surgery between autologous fibrin glue (AFG) and suture technique. This was a randomized, controlled, single blind clinical trial that conducted in National Eye Center, Cicendo Eye Hospital Bandung from October−December 2010. Subjects were randomly assigned to two groups and as result 12 patients belong to AFG group and 14 belong to suture group. Digital slit-lamp photographs were taken at 1st week, 2nd week and 4th week postoperatively for observation. Sutures were masked using photo-editing software and one masked observers objectively graded the digital photograph for degree of hyperemia. Statistical analysis was performed using Mann Whitney Test. The results of this study showed that the degree of hyperemia was significantly lower in AFG group (hyperemia degree 2.5, 2 and 1.5) than in suture group (hyperemia degree 4, 3 and 2) at 1st week, 2nd week and 4th week post operatively (p<0.05). In conclusion, the use of AFG for graft fixation in inflamed pterygium surgery produced significantly lower hyperemia degree. [MKB. 2013;45(3):174–9]Key words: Autologous fibrin glue, inflammed pterygium DOI: http://dx.doi.org/10.15395/mkb.v45n3.148
Prothrombin Time, Activated Partial Thromboplastin Time, Fibrinogen, dan D-dimer Sebagai Prediktor Decompensated Disseminated Intravascular Coagulation Sisseminated pada Sepsis Fenny, -; Dalimoenthe, Nadjwa Zamalek; Noormartany, -; Pranggono, Emmy; Dewi, Nina Susana
Majalah Kedokteran Bandung Vol 43, No 1
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15395/n

Abstract

AbstrakSepsis adalah respons sistemik terhadap infeksi dan terutama terjadi pada pneumonia. Sepsis dapat menyebabkan komplikasi disseminated intravascular coagulation (DIC) yang dibedakan menjadi compensated dan decompensated DIC. Tujuan penelitian ini adalah untuk menentukan apakah nilai prothrombin time (PT), activated partial thromboplastin time (aPTT), kadar fibrinogen, dan D-dimer dapat digunakan sebagai prediktor decompensated DIC pada penderita sepsis. Penelitian dilakukan di Laboratorium Patologi Klinik Rumah Sakit Hasan Sadikin Bandung mulai September 2008 sampai Juni 2010. Subjek penelitian adalah penderita sepsis yang disebabkan pneumonia. Nilai PT, aPTT, kadar fibrinogen, dan D-dimer semua subjek sepsis dicatat kemudian dilakukan pengamatan sampai subjek dinyatakan mengalami decompensated atau non-decompensated DIC; selanjutnya dilakukan analisis nilai PT, aPTT, kadar fibrinogen, dan D-dimer pada kelompok decompensated dan non-decompensated DIC. Penelitian menggunakan rancangan cohort. Subjek berjumlah 39 orang (58%) penderita sepsis dengan luaran decompensated DIC dan 28 orang (42%) penderita sepsis dengan luaran non-decompensated DIC. Dari parameter hemostasis yang diperiksa, didapatkan bahwa nilai PT, aPTT, dan fibrinogen merupakan prediktor decompensated DIC pada penderita sepsis dengan risiko relatif (RR) masing-masing 240,500; 7,157; dan 6,421. Simpulan, prothrombin time, aPTT, dan fibrinogen merupakan pemeriksaan untuk mengetahui aktivasi koagulasi. Parameter hemostasis yang merupakan prediktor decompensated DIC pada penderita sepsis adalah nilai PT dan aPTT yang memendek serta kadar fibrinogen yang meningkat. [MKB. 2011;43(1):49–54].Kata kunci: Activated partial thromboplastin time, D-dimer, disseminated intravascular coagulation, fibrinogen, prothrombin time, sepsisProthrombin Time, Activated Partial Thromboplastin Time, Fibrinogen, and D-dimer as a Predictor of Decompensated Disseminated Intravascular Coagulation in SepsisSepsis is a systemic response to infection especially in pneumonia case. Sepsis can cause complications such as disseminated intravascular coagulation (DIC) which can be divided into compensated and decompensated DIC. The purpose of this study was to assess whether the value of prothrombin time (PT), activated partial thromboplastin time (aPTT), fibrinogen, and D-dimer levels can be used as predictors of decompensated DIC in sepsis patients. This study was conducted at the Laboratory of Clinical Pathology Rumah Sakit Hasan Sadikin Bandung since September 2008 to June 2010. Subjects were patients with sepsis caused by pneumonia. PT and aPTT values, fibrinogen, and D-dimer levels was recorded from all sepsis patients then patients were observed until diagnosed decompensated or non-decompensated DIC, then the value of PT, aPTT, fibrinogen and D-dimer levels in the group of decompensated DIC and non-decompensated DIC were analysed. This study used cohort design. Subjects were 39 sepsis patients (58%) with outcome decompensated DIC and 28 sepsis patients (42%) with outcome non-decompensated DIC. From the hemostasis parameter test out, it was found that PT, aPTT, and fibrinogen were the predictor of decompensated DIC in patients with sepsis with relative risk 240.500, 7.157, and 6.421; respectively. Conclusions, prothrombin time, aPTT, fibrinogen are the test to know coagulation activation. Hemostasis parameter to predict decompensated DIC in sepsis patients are the shorten PT, aPTT, and the increased fibrinogen. [MKB. 2011;43(1):49–54].Key words: Activated partial thromboplastin time, D-dimer, disseminated intravascular coagulation, fibrinogen, prothrombin time, sepsi DOI: http://dx.doi.org/10.15395/mkb.v43n1.44
Profile of Anemia on Lung Tuberculosis at Dr. Hasan Sadikin General Hospital and Community Lung Health Center Bandung Marizka Adzani; Nadjwa Zamalek Dalimoenthe; Indra Wijaya
Althea Medical Journal Vol 3, No 1 (2016)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (540.663 KB)

Abstract

Background: Tuberculosis (TB) is a chronic infectious disease caused by Mycobacterium tuberculosis that can cause anemia. Anemia is a lack of erythrocyte mass needed to carry adequate oxygen to the whole bodies. The aim of this study was to describe the anemia in adult lung TB patients at Dr. Hasan Sadikin General Hospital and Community Lung Health Center (Balai Kesehatan Paru Masyarakat, BKPM) Bandung.Methods: This descriptive study was conducted from August to October 2014. Study subjects were adult TB patients who came for their first control to TB Clinic Dr. Hasan Sadikin General Hospital and BKPM Bandung after receiving oral antituberculosis drugs, and willing to comply in study. The exclusion criteria were patients with other chronic diseases, pregnant, menorrhagia, and hemoptoe. Three mL of vein blood was taken and put into EDTA tube for routine hematologic measurement using automatic hematologic analyzer, sysmex KX-21®.Results: There was 31 (63.26%) from 49 adult lung TB patients suffered anemia. In male subjects, mild and moderate anemia were found 57.14% and 42.86% respectively, and in female subjects were 58.82% and 41.18% respectively. In males, there were 42.86% normochromic normocytic, 42.86% hypochromic microcytic, 7.14% normochromic microcytic, and 7.14% hypochromic normocytic, while in females, there were 5.88% normochromic normocytic, 47.06% hypochromic microcytic, 17.65% normochromic microcytic, 29.41% hypochromic normocytic.Conclusions: Anemia is found in 63.26% adult lung TB patients, most of which are mild anemia and hypochromic microcytic, especially in female subjects. [AMJ.2016;3(1):137–40] DOI: 10.15850/amj.v3n1.473
Green Tea and its Effect on Hemostasis Measured by Thrombelastography Bryant Alyzandyr Eumhyn Chua; Trully D. Sitorus; Nadjwa Zamalek Dalimoenthe
Althea Medical Journal Vol 2, No 1 (2015)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (620.611 KB)

Abstract

Background: Increasing health problems may come from changes in lifestyle including stressful lifestyles, high calorie diets, and lack of physical activity. Those may also lead to an increase occurrence of abnormal hemostasis. Green tea has been well known for its many benefits, including its antithrombotic effect. The aim of this study was to determine whether the consumption of green tea actually affects hemostasis and to measure changes in hemostatic parameters after its consumption.Methods: A preliminary explorative study was conducted on 3 healthy female subjects aged between 21 to 22 years old for 8 weeks from October to November 2012 in Jatinangor, Sumedang, Indonesia. The subjects were subjected to initial thrombelastography analysis and started drinking green tea twice a day after meals. The solution was made by steeping a teabag in 250ml water of 70°C for 2 minutes. After 8 weeks, another thrombelastography analysis was performed to the subjects. Results: Pre- and post-intervention results of the analysis were averaged and compared according to the parameters. The results of this study showed prolonged R (Reaction-time) and K (K-time), decreased α (angle) and MA (Maximum Amplitude), and increased LY30 (lysis at 30 minutes), showing an overall reduction in coagulability. Conclusions: The consumption of green tea twice a day for 8 weeks affects hemostasis with hemostatic parameters measured by thrombelastography show differences before and after consumption.Keywords: Green tea, hemostasis, thrombelastographyDOI: 10.15850/amj.v2n1.426
Neutrophil-Lymphocyte Ratio (NLR) and Lymphocyte-Monocyte Ratio (LMR) as Covid-19 Screening Parameters Heny Syahrini; Trinugroho Heri Fadjari; Nadjwa Zamalek Dalimoenthe
JURNAL INDONESIA DARI ILMU LABORATORIUM MEDIS DAN TEKNOLOGI Vol 4 No 1 (2022): The future of diagnostic laboratory testing
Publisher : Universitas Nahdlatul Ulama Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33086/ijmlst.v4i1.2281

Abstract

Covid-19 diagnosis generally uses RT-PCR as the gold standard to detect coronavirus-2 (SARS-CoV-2); however, this method requires advanced laboratory equipment. Alternatively, Neutrophil-Lymphocyte Ratio (NLR) and Lymphocyte-Monocyte Ratio (LMR) can be used to identify viral infection. The study aimed: (1) to compare each NLR and LMR ratio in patients with and without COVID-19 and (2) to test the effectiveness of these ratios in identifying COVID-19. The study was conducted at the Haji Adam Malik Central General Hospital by acquiring 87 medical records data. The complete hematologic profile was analyzed from patients with and without COVID-19. The NLR and LMR ratio accuracy were analyzed as a screening tool for COVID-19. The AUC of NLR was 0.638, with cut-off ≤ 2.49, 47.6% sensitivity, and 80% specificity; therefore, the NLR accuracy as a screening for COVID-19 was defined as not good (just sufficient) because of AUC <0,7. The AUC of LMR was 0.661, with cut-off ≥ 3.23, 45.2% sensitivity, and 82.2% specificity; therefore, the LMR accuracy as a screening parameter for COVID-19 is defined as not good (just sufficient) because of AUC <0,7. There were significant differences in hematologic profile in neutrophil, lymphocyte, NLR, LMR between the patients in the COVID-19 group and non-COVID-19 group. NLR and LMR cannot be used as a screening tool because the Area Under Curve (AUC) is not good enough (just sufficient) in detecting COVID-19.
Validitas Skoring Hematologi Rodwell Untuk Deteksi Dini Sepsis Neonatorum Awitan Dini Tena Rosmiati Iskandar; Nadjwa Zamalek Dalimoenthe; Tetty Yuniaty; Dewi Kartika Turbawaty
Sari Pediatri Vol 16, No 5 (2015)
Publisher : Badan Penerbit Ikatan Dokter Anak Indonesia (BP-IDAI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (76.575 KB) | DOI: 10.14238/sp16.5.2015.330-6

Abstract

Latar belakang. Sepsis neonatorum awitan dini adalah sindrom klinis dengan gejala infeksi sistemik yangmerupakan penyebab utama kesakitan dan kematian pada neonatus. Diagnosis sepsis neonatorum seringkalisulit karena gejala klinisnya tidak khas. Pemeriksaan biakan darah sebagai baku emas, memerlukan waktu48-72 jam. Sistem skoring hematologi (SSH) Rodwell dapat digunakan sebagai alat bantu deteksi dinisepsis neonatorum awitan dini.Tujuan. Menentukan nilai sensitivitas dan spesifisitas SSH Rodwell dalam mendeteksi sepsis neonatorumawitan dini.Metode. Penelitian deskriptif dengan rancangan potong lintang dilakukan di RSUP dr. Hasan SadikinBandung antara bulan September sampai November 2013. Subjek penelitian adalah neonatus berumurkurang atau sama dengan 5 hari dengan faktor risiko sepsis neonatorum.Hasil. Pada neonatus ditemukan hasil biakan darah positif 45 (40,9%) subjek. Sistem skoring hematologiRodwell memiliki sensitivitas 100% dan spesifisitas 66% untuk mendeteksi sepsis neonatorum awitandini.Kesimpulan. Pemeriksaan SSH Rodwell memiliki nilai sensitivitas tinggi dan nilai spesifisitas sedang dalammenegakkan diagnosis sepsis neonatorum awitan dini.
SKRINING THALASSEMIA BETA MINOR PADA SISWA SMA DI JATINANGOR putri alyumnah; Mohammad Ghozali; Nadjwa Zamalek Dalimoenthe
Jurnal Sistem Kesehatan Vol 1, No 3 (2016): Volume 1 Nomor 3 Maret 2016
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (238.88 KB) | DOI: 10.24198/jsk.v1i3.10358

Abstract

Jenis Thalassemia yang paling banyak ditemukan adalah Thalassemia beta. Tercatat 10% penduduk Indonesia merupakan pembawa gen Thalassemia beta. Thalassemia beta minor sulit dideteksi karena bersifat asimtomatik sehingga peranan skrining sebagai deteksi dini sangat diperlukan. Sampai dengan saat ini di Indonesia belum dilakukan program skrining rutin Thalassemia.Tujuan penelitian ini untuk mengetahui frekuensi Thalassemia beta minor pada siswa- siswi SMA di Jatinangor. Metode Penelitan deskriptif kuantitatif, dengan teknik pengambilan data cross sectional telah dilakukan sejak bulan September sampai dengan Oktober 2015. Subyek penelitian terdiri dari siswa-siswi di 5 SMA kelas 10 dan 11 yang terregistrasi di Jatinangor. Hasil Dari seluruh siswa-siswi kelas 10 dan 11 SMA di Jatinangor, hanya ada 292 yang hadir saat penyuluhan, dan hanya 130 orang di antaranya yang bersedia mengikuti penelitian. Pada penelitian ini ditemukan 12 (9,3%) orang sebagai thalassemia beta minor. Pembahasan pada penelitian ini ditemukan 12 (9,3%) orang sebagai thalassemia beta minor. Pada penelitian lain di Banyumas didapatkan 8%.Kata kunci: Skrining,Thalassemia,Thalassemia beta minor