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All Journal Althea Medical Journal Global Medical and Health Communication Majalah Kedokteran Majalah Obstetri dan Ginekologi Journal of Medicine and Health Indonesian Journal of Obstetrics & Gynecology Science Indonesian Journal of Obstetrics and Gynecology (Majalah Obstetri dan Ginekologi Indonesia) Jurnal Teknologi Sistem Informasi dan Aplikasi Jurnal Teknologi Informatika dan Komputer Jurnal Mekanik Terapan MEDICINUS Journal of Medicine and Health
Adhi Pribadi
Department Of Obstetric And Gynecology, Faculty Of Medicine, Universitas Padjadjaran/Dr. Hasan Sadikin General Hospital, Bandung
Automotive Engineering Biochemistry, Genetics & Molecular Biology Computer Science & IT Dentistry Electrical & Electronics Engineering Energy Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Materials Science & Nanotechnology Mechanical Engineering Medicine & Pharmacology Neuroscience Nursing Public Health

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Expression of Ki-67 has Correlation with the Degree and Size of Endometriosis Cysts Anwar, Ruswana; Alif, Muhammad; Pribadi, Adhi
Journal of Medicine and Health Vol 1, No 1 (2015)
Publisher : Maranatha Christian University

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Endometriosis is one of the most common gynecological problem. Cells resulted in chronic inflammation and progressive, proliferative, invasive and even infiltrating an area that resembles the character of the malignancy. Ki-67 is an antigen on the cell nucleus that is found only in actively dividing cells. Expression of Ki-67 are associated with an aggressive tumor and metastasis. This study aims to determine the level of Ki-67 expression correlation with stage and size of the endometriosis cyst. Methods research is observational analytic cross cut method on 56 paraffin blocks of patients who have been diagnosed with endometriosis and had performed a laparotomy or laparoscopic surgery in Dr Hasan Sadikin Hospital. The results showed a significant relationship between the level of expression of Ki-67 with endometriosis cyst size (p <0.001) with a fairly strong relationship (0.55) according to statistics based on criteria Guilford. Moreover the results also showed a significant relationship between the level of expression of Ki-67 with endometriosis stage (p <0.001) with a fairly close relationship (0.564) according to statistics based on criteria Guilford. It can be concluded that the expression of Ki-67 associated with cyst size and stage of endometriosis. Keywords: Ki-67, endometriosis stage, endometriosis cyst
The Teratogenic Effect of The Mindi (Melia azedarach L) Leaves Ethanol Extract on Mice (Mus musculus) Fetus Sutomo, Adisti Erlina; Sitorus, Trully D.; Pribadi, Adhi
Althea Medical Journal Vol 2, No 2 (2015)
Publisher : Althea Medical Journal

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (571.353 KB)

Abstract

Background: Mindi leaves (Melia azeradach L.) were used by Indonesians as a traditional medicine for pregnant women because it was considered to be safe. Mindi leaves contain several active compounds and one of them is suspected as a teratogen and can disrupt fetus growth in gestation. This research aims to know about the teratogenic effect of ethanol extract of Mindi leaves by using mice.Methods: This was a laboratory experimental study using 27 pregnant female mice (Mus musculus) of Swiss Webster strain which were randomly assigned to 3 groups (n=9) controlled (Carboxymethyl cellulose 1% for day 1–18 of pregnancy), group I (mindi leaves ethanol extract 3.22 mg+Carboxymethyl cellulose 1% day 1–5 of pregnancy), and group II (mindi leaves ethanol extract 3.22 mg+Carboxymethyl cellulose 1% day 6–18 of pregnancy). Observation was done to see total amount of fetus, live normal fetus count, length and weight of fetus, abnormal fetus count consisting of dead fetus count with normal and abnormal external morphology, and resorbed fetus count. This research was done from October to November 2012 in Pharmacological laboratory of Faculty of Medicine Universitas Padjajdjaran. Data analysis utilized unpaired t-test.Results: The result showed a significant difference (p<0.05), seen from live normal fetus count and abnormal fetus count consisting of dead fetus count with normal and abnormal external morphology, and resorpted fetus count. Conclusions: Administration of Mindi leaves extract during pregnancy of mices can cause teratogenic effect.[AMJ.2015;2(1):221–25]
Ki-67 Expression is Correlated with Cyst Size and Stage of Endometriosis Alif, Muhammad; Anwar, Ruswana; Pribadi, Adhi
Indonesian Journal of Obstetrics and Gynecology Volume. 1, No. 3, July 2013
Publisher : Indonesian Socety of Obstetrics and Gynecology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (95.209 KB) | DOI: 10.32771/inajog.v1i3.350

Abstract

Objectives: To analyze the association between Ki-67 expression with the cyst size and stage of endometriosis, and the correlation strength between them. Methods: A cross-sectional analytic observational study involving 56 paraffin blocks from subjects diagnosed with endometriosis, who had undergone laparotomy or laparoscopic surgery. The study is conducted in Dr. Hasan Sadikin Hospital in September-November 2012. Results: Shows a significant association between Ki-67 expression and the size of endometriotic cyst (p &lt; 0.0001), also with a strong correlation (r = 0.55) according to Guilford criteria. There is also a significant association between Ki-67 expression and the endometriosis stage (p &lt; 0.0001), with a strong correlation (r = 0.564) according to Guilford criteria. Conclusion: Ki-67 expression is correlated with the cyst size and stage of endometriosis. [Indones J Obstet Gynecol 2013; 1-3: 124-8] Keywords: endometriosis stage, endometriotic cyst size, Ki-67
Cover JMT vol 1 no 2 Nov 2020 Adhi, Pribadi
Jurnal Mekanik Terapan Vol 1, No 2 (2020): November
Publisher : Jurnal Mekanik Terapan

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Abstract

The Teratogenic Effect of The Mindi (Melia azedarach L) Leaves Ethanol Extract on Mice (Mus musculus) Fetus Adisti Erlina Sutomo; Trully D. Sitorus; Adhi Pribadi
Althea Medical Journal Vol 2, No 2 (2015)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (571.353 KB)

Abstract

Background: Mindi leaves (Melia azeradach L.) were used by Indonesians as a traditional medicine for pregnant women because it was considered to be safe. Mindi leaves contain several active compounds and one of them is suspected as a teratogen and can disrupt fetus growth in gestation. This research aims to know about the teratogenic effect of ethanol extract of Mindi leaves by using mice.Methods: This was a laboratory experimental study using 27 pregnant female mice (Mus musculus) of Swiss Webster strain which were randomly assigned to 3 groups (n=9) controlled (Carboxymethyl cellulose 1% for day 1–18 of pregnancy), group I (mindi leaves ethanol extract 3.22 mg+Carboxymethyl cellulose 1% day 1–5 of pregnancy), and group II (mindi leaves ethanol extract 3.22 mg+Carboxymethyl cellulose 1% day 6–18 of pregnancy). Observation was done to see total amount of fetus, live normal fetus count, length and weight of fetus, abnormal fetus count consisting of dead fetus count with normal and abnormal external morphology, and resorbed fetus count. This research was done from October to November 2012 in Pharmacological laboratory of Faculty of Medicine Universitas Padjajdjaran. Data analysis utilized unpaired t-test.Results: The result showed a significant difference (p<0.05), seen from live normal fetus count and abnormal fetus count consisting of dead fetus count with normal and abnormal external morphology, and resorpted fetus count. Conclusions: Administration of Mindi leaves extract during pregnancy of mices can cause teratogenic effect.[AMJ.2015;2(1):221–25]
Sindrom Metabolik: Komplikasi Pertumbuhan Janin Intrauterin yang Terhambat Adhi Pribadi; Johanes C. Mose
Majalah Kedokteran UKI Vol. 30 No. 2 (2014): APRIL - JUNI
Publisher : Fakultas Kedokteran Universitas Kristen Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33541/mkvol34iss2pp60

Abstract

Abstrak Perkembangan manusia intrauterin berkorelasi dengan penyakit yang timbul pada periode dewasa. Hipotesis perkembangan menyatakan bahwa risiko suatu penyakit dalam jangka panjang secara inisial diinduksi respons adaptasi janin. Respons termasuk perubahan metabolisme dan hormon, yang mungkin berpengaruh terhadap pertumbuhan organ. Penelitian epidemiologi menunjukkan BBLR dan PJT berhubungan dengan penyakit jantung, Stroke, DM tipe 2, obesitas, Sindrom Metabolik, dan osteoporosis. Periode perikonsepsi merupakan masa yang sensitif terhadap perubahan dan defisiensi nutrisi. Memori isyarat lingkungan terekam sejak konsepsi sampai persalinan oleh janin dan diturunkan pada generasi berikutnya. Hal ini meningkatkan dugaan bahwa penyakit metabolik diturunkan berbasis epigenetik dan tidak murni berbasis multigenik.Kata Kunci: intrauterin, perkembangan, PJT, sindrom metabolik Abstract Adult period diseases correlate with intrauterine development. Hypothesis development notes that the risk in latter life is induced by intrauterine fetal adaptive responses. The responses include: mal-development of metabolism and hormone that can influence alter fetal organs development. Result of epidemiology study stated that IUGR has significant correlation with cardiac disease, stroke attack, Diabetes Mellitus type 2, obesity, metabolic syndrome, and osteoporosis. Periconception period is a sensitive period of change and nutrition deficiency. Environment memory has been recorded by the fetus since conception until fetal delivery and has consequences to be transfered to the offspring. This increases the assumption that metabolic diseases signal have epigenetic memory base and not merely multigenic base.Kay Words: intrauterine, development, IUGR, metabolic syndrome
Effect of Integrated Antenatal Care Training on Midwife Service Quality Improvement Melsa Sagita Imaniar; Hadi Susiarno; Adhi Pribadi; Herry Herman; Dida Akhmad Gurnida; Hadyana Sukandar
Global Medical & Health Communication (GMHC) Vol 8, No 2 (2020)
Publisher : Universitas Islam Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (231.705 KB) | DOI: 10.29313/gmhc.v8i2.3457

Abstract

Antenatal care (ANC) is the most effective strategy for preventing complications in pregnancy. However, the current quality of midwife antenatal care services is still considered low. One of the indicators used for assessing midwifery service quality is the technical competency indicator that includes history taking, physical examination, case management and follow up, examination recording, and effective information, communication, and education (IEC). This study aimed to measure the effect on integrated antenatal care training on the quality of midwife services. The design was a pre-test and post-test quasi-experimental study conducted in Manonjaya Public Health Center, Tasikmalaya district, from November to December 2017. Simple random sampling was applied to get 20 respondents for each intervention and control groups. The bivariate analyses used in this study were the paired t test and the Mann-Whitney test. Results showed an overall increase in service quality scores in the intervention and control groups by 5.5% and 0.86%, respectively, with a significant difference in the increase between the two groups (p<0.05). Therefore, there is a significant increase in the quality of midwife after implementing the integrated ANC module and training to midwives. PENGARUH PELATIHAN ANTENATAL CARE TERPADU TERHADAP PENINGKATAN KUALITAS PELAYANAN BIDANAntenatal care (ANC) merupakan strategi pencegahan komplikasi dalam kehamilan paling efektif. Namun, kualitas pelayanan antenatal care bidan saat ini dinilai masih rendah. Salah satu indikator yang digunakan untuk menilai kualitas pelayanan kebidanan adalah indikator kompetensi teknis yang meliputi anamnesis, pemeriksaan fisik, penatalaksanaan dan tindak lanjut kasus, pencatatan pemeriksaan, serta komunikasi, informasi, dan edukasi (KIE) yang efektif. Penelitian ini bertujuan mengukur pengaruh pelatihan antenatal care terpadu terhadap kualitas pelayanan bidan. Desain penelitian ini menggunakan pre-test and post-test quasi-experimental yang dilaksanakan di Puskesmas Manonjaya Kabupaten Tasikmalaya dari November hingga Desember 2017. Pengambilan sampel dilakukan secara simple random sampling untuk mendapatkan 20 responden untuk tiap-tiap kelompok intervensi dan kontrol. Analisis bivariat yang digunakan dalam penelitian ini adalah uji t berpasangan dan Uji Mann-Whitney. Hasil penelitian menunjukkan peningkatan skor kualitas pelayanan secara keseluruhan pada kelompok intervensi dan kontrol sebesar 5,5% dan 0,86% masing-masing dengan perbedaan peningkatan yang signifikan antara kedua kelompok (p<0,05). Simpulan, terdapat peningkatan kualitas bidan yang signifikan setelah penerapan modul ANC terintegrasi dan pelatihan kepada bidan.
Expression of Ki-67 has Correlation with the Degree and Size of Endometriosis Cysts Ruswana Anwar; Muhammad Alif; Adhi Pribadi
Journal of Medicine and Health Vol. 1 No. 1 (2015)
Publisher : Universitas Kristen Maranatha

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (187.129 KB) | DOI: 10.28932/jmh.v1i1.496

Abstract

Endometriosis is one of the most common gynecological problem. Cells resulted in chronic inflammation and progressive, proliferative, invasive and even infiltrating an area that resembles the character of the malignancy. Ki-67 is an antigen on the cell nucleus that is found only in actively dividing cells. Expression of Ki-67 are associated with an aggressive tumor and metastasis. This study aims to determine the level of Ki-67 expression correlation with stage and size of the endometriosis cyst. Methods research is observational analytic cross cut method on 56 paraffin blocks of patients who have been diagnosed with endometriosis and had performed a laparotomy or laparoscopic surgery in Dr Hasan Sadikin Hospital. The results showed a significant relationship between the level of expression of Ki-67 with endometriosis cyst size (p <0.001) with a fairly strong relationship (0.55) according to statistics based on criteria Guilford. Moreover the results also showed a significant relationship between the level of expression of Ki-67 with endometriosis stage (p <0.001) with a fairly close relationship (0.564) according to statistics based on criteria Guilford. It can be concluded that the expression of Ki-67 associated with cyst size and stage of endometriosis. Keywords: Ki-67, endometriosis stage, endometriosis cyst
Elemen Zink sebagai Penopang Pertumbuhan dan Kehidupan Janin Intrauterin Pribadi, Adhi
MEDICINUS Vol. 36 No. 3 (2023): MEDICINUS
Publisher : PT Dexa Medica

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56951/2x5pd478

Abstract

Zink (zinc/Zn)adalah mineral penting yang diketahui mempunyai fungsi fisiologis yang berpengaruh terhadap sistem kekebalan tubuh. Zink memainkan peran yang sangat penting dalam berbagai fungsi tubuh manusia, termasuk sintesis protein dan metabolisme asam nukleat. Zink juga merupakan salah satu nutrisi dasar yang dibutuhkan selama kehamilan untuk perkembangan normal dan pertumbuhan janin di samping mikronutrien lainnya seperti besi dan kalsium. Kekurangan zink selama kehamilan menyebabkan dampak permanen pada bayi baru lahir seperti gangguan pertumbuhan, abortus spontan, cacat bawaan, dan luaran kehamilan yang buruk. Zinc memainkan peran yang sangat penting dan kritis dalam berbagai fungsi tubuh manusia termasuk sintesis protein dan metabolisme asam nukleat. Dampak defisiensi Zn sangat menonjol bahkan pada kehidupan janin intrauterin. Studi suplementasi Zn pada populasi yang pernah dilakukan sebelumnya menunjukkan hasil yang bertentangan pada berbagai outcome kehamilan. Defisiensi Zn menyebabkan potensi peningkatan stres oksidatif dan berakhir dengan kematian sel. Beberapa penelitian yang dilakukan mengenai status Zn pada ibu hamil menunjukan kadar Zn yang rendah pada neonatus dengan status kecil pada masa kehamilan serta peningkatan kasus preterm. Suplementasi zink oral merupakan upaya potensial untuk mengurangi risiko kelahiran bayi dengan berat badan rendah dan pada akhirnya mencegah morbiditas dan mortalitas bayi baru lahir yang terkait dengan kondisi ini. Fungsi Zn pada ibu termasuk mendukung pertumbuhan uterus selama kehamilan dan menurunkan potensi preeklamsia, namun bukti yang mendukung suplementasi zink secara rutin masih belum tersedia. Dampak defisiensi Zink relatif buruk selama kehamilan, meskipun demikian bukti penelitian mengenai kebutuhan suplementasi rutin yang diberikan pada semua ibu hamil masih menjadi perdebatan, karena manfaatnya yang secara metaanalisis tidak terlalu nyata. Suplementasi lebih disarankan pada populasi risiko tinggi agar tidak terjadi outcome yang buruk pada kehamilan. 
The effectiveness of McDonald Transvaginal Cerclage in preventing preterm labor Pribadi, Adhi
Majalah Obstetri & Ginekologi Vol. 31 No. 3 (2023): December
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/mog.V31I32023.157-161

Abstract

HIGHLIGHTS Cervical cerclage is effective to prevent preterm birth. The use of silk thread (monofilament) or ribbon for suture material is successful in maintaining pregnancy.   ABSTRACT Objective: To determine the success and effectiveness of the use of McDonald's transvaginal cerclage techniques and the thread material used to prevent premature labor in cases of uterine cervical incompetence. Case Report: This was a retrospective study. Data for 13 patients were taken from the medical records of Dr. Hasan Sadikin Hospital, Bandung, Indonesia, and private clinics from the years of 2009 to 2021. The procedure used was a McDonald's cerclage technique with material suture using silk no. 1 and mersilene tape thread. Indications were used based on a previous history of obstetrics preterm, abortion beyond 13 weeks or based on cervical length. The criterion for cerclage success was achieving pregnancy at 36 weeks. Adjuvant therapy using tocolytics was administered intermittently in all patients. The patient was advised to douch the vagina using an antiseptic if there was excessive vaginal discharge. According to the success criteria, 92% of elective McDonald cerclages were able to maintain a pregnancy well up to 36 weeks. A total of 11 elective cases used silk no. 1, while mersilene was used in 1 case. The silk no. 1 thread material was used in the elective cases with 91% success. One case using mersilene tape was able to maintain pregnancy until delivery by cesarean section at 38 weeks of age with bicornuate uterine pathology. One case of emergency cerclage with silk no. 1 failed to maintain pregnancy until 36 weeks. Conclusion: The use of cerclage in conjunction with adjuvant therapy and antiseptic douching efforts has resulted in good success in maintaining pregnancy in cases of cervix incompetence with a history of obstetric preterm and recurrent abortus. When there is no tape-shaped thread material suture, the use of silk thread or other monofilament threads with a larger diameter can be considered.
Co-Authors AA Sudharmawan, AA Achmad Fauzan, Achmad Adisti Erlina Sutomo Adisti Erlina Sutomo, Adisti Erlina Akhmad Yogi Pramatirta, Akhmad Yogi Aldiansyah, Dudy Aldika Akbar, Muhammad Ilham Alifa, Dhara Amillia Siddiq, Amillia Andi Kurniadi, Andi Andi Rinaldi Andonotopo, Wiku Andri Reza Rahmadi Aqilah, Nurjihan Syarifah Arnova Reswari, Arnova ASTRI ASTUTI Aziz, Muhammad Alamsyah Bachnas, Muhammad Adrianes Budi Handono Cool, Charlotte Johanna Cut Meurah Yeni Dany Hilmanto Dewi, Sawitri Dida Akhmad Gurnida Dodi Suardi Elsa Pudji Setiawati Evert Solomon Pangkahila Evicenna Naftuchah Riani, Evicenna Naftuchah Firmansyah, Silva Elifa Hadyana Sukandar Hanom Husni Syam Herry Herman Hidayat, Dini I Nyoman Hariyasa Sanjaya Ismayadi, Tedi Jeffry Iman Gurnadi, Jeffry Iman Johanes C. Mose Julian Dewantiningrum Kurjak, Asim Laniyati Hamijoyo, Laniyati Luthfi Rahman, Luthfi Megantoro, Izzati Faustina Melsa Sagita Imaniar Muhammad Alif Nugrahani, Annisa Dewi Nuswil Bernolian Pramono, Mochammad Besari Adi Pramudyo, Miftah Pratiwi, Erlina Lutfiayu Putra, Ridwan Abdullah Rachmawati, Anita Ritonga, Mulyanusa Ritonga, Mulyanusa Amarullah Riva, Salma Nisrina Ruswana Anwar Ryan Saktika Mulyana Setyorini Irianti Solly Aryza Sri Sulistyowati Stanojevic, Milan Sulaiman, Aina Zakia Suri, Mulhamatus Latifatus Susiarno, Hadi Syahdony, Farrel Nolan Trully D. Sitorus Trully D. Sitorus Utami, Hasri Larasati Wilis Dwi Pangesti Windi Nurdiawan Wiradnyana, Anak Agung Gede Putra Yordian, Kendry Savira