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The Analgesic Effect of Ethanol Extract Soursop (Annona muricata L.) Leaves in Wistar Rats Kuswinarti Kuswinarti; Kendry Savira; Reno Rudiman
Althea Medical Journal Vol 5, No 4 (2018)
Publisher : Faculty of Medicine Universitas Padjadjaran

Background: Pain is an emotional and sensory experience that is unpleasant and related to tissues damage. In the past, Soursop (Annona muricata L.) leaves have been believed to be able to relieve pain. This study aimed to explore the analgesic effect of soursop leaves and its effective dose in an animal model. Methods: Wistar rats (n=25) had been used in this experimental study, divided into 5 groups; consisting of a negative control group, experiment groups using extract soursop leaves with doses of 200mg/kgbw, 400 mg/kgbw and 600 mg/kgbw, and natrium diclofenac as a positive control. One hour after treatment, all groups of rats were induced by carrageenan-lambda in the feet. The basal retraction of rats’ legs was measured in 47oC water and repeated at two, four, and six hours. The data were analyzed using analysis of variance and Tukey’s test. Result: The dose of 200 mg/kgbw had no analgesic effect (p>0.05), while the dose of 600 mg/kgbw had the highest analgesic effect at 7.72 seconds on the 4th hour of induction. On the 6th hour, the dose of 400 mg/kgbw had the highest analgesic effect at 3.58 seconds.Conclusions: Extract soursop (Annona muricata L.) leaves in this study have been proven to have an analgesic effect.

Knowledge of Housewives Regarding Non Steroid Anti Inflammatory Drug Use on Joint Pain in Hegarmanah Village Jatinangor Adi Mulyono Gondopurwanto; Kuswinarti Kuswinarti; Yusuf Wibisono
Althea Medical Journal Vol 3, No 1 (2016)
Publisher : Faculty of Medicine Universitas Padjadjaran

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Background: Joint pain is frequently found in daily life activities. The prevalence of joint pain increases within the age. One of the medicine used for joint pain is non-steroidal anti-inflammatory drug (NSAID). In connection with inappropriate usage and their side effects, this study aimed to seek the extent ofhousewives’ knowledge on the use of NSAID for joint pain in Hegarmanah village, Jatinangor subdistrict.Methods: This cross-sectional descriptive study was conducted in October 2013 to the housewives resided in Hegarmanah village, Jatinangor subdistrict, West Java. Questionaire sheet was distributed to each of 110 housewives that had been stratifiedly with randomized sample. The questionaire contained identity, age, education level, and knowledge of NSAID in related to joint pain.Results: Based on the data collected, 73 subjects had adequate level of the knowledge and 37 subjects were in a poor level of the knowledge. The proportion of respondents who knew that joint pain was the pain occurs in the joint was 99.1%, the proportion of respondents who knew that the pain relieving drugs are called NSAID group was 40.9%, the proportion of respondents who knew that NSAID had a side-effect was 73.6%, and the proportion of respondents who knew that the side-effect of NSAID is abdominal pain was 61.8%.Conclusions: Most of the housewives in Hegarmanah Subdistrict have adequate knowledge in the use ofNSAID for joint pain relief. [AMJ.2016;3(1):115–9]DOI: 10.15850/amj.v3n1.711

Treatment of Rheumatoid Arthritis with Methotrexate Alone or A Combination of Methotrexate and Hydroxychloroquine Natharubini Nadarajah; Riardi Pramudyo; Kuswinarti Kuswinarti
Althea Medical Journal Vol 3, No 3 (2016)
Publisher : Faculty of Medicine Universitas Padjadjaran

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Background: Rheumatoid arthritis (RA) is an autoimmune disease that causes significant morbidity in most patients and also premature mortality in some. To prevent this, therapeutic approaches call for the early treatment of RA by using disease-modifying antirheumatic drugs (DMARDSs), either as single therapy or combination therapy. Although in the previous decade DMARDs were rarely used as combination, however now they are used widely to treat RA. The objective of this study was to compare the effectiveness of methotrexate (MTX) alone and the combination of MTX & hydroxychloroquine (HCQ) in RA patients.Methods: An analytic retrospective cohort study was conducted from May 2014 until October 2014, on 46 patients with RA in the rheumatology clinic of Dr. Hasan Sadikin General Hospital Bandung from January 2009−October 2014 who were taking MTX or MTX & HCQ for at least 1 year. The secondary data obtained from these patients’ medical record were then analyzed using the independent t-test and Mann-Whitney test.Results: The study showed that 93.48% of the patients were females. The mean change in disease activity measures were not significant for any of the parameter (p-value for SJC = 0.337; TJC = 0.676; ESR = 0.780). Also the comparisons of the disease activity score (DAS 28) before and after therapy was not significant (p-value = 0.584).Conclusion: There is no difference in the effectiveness of DMARD monotherapy with MTX and combination therapy with MTX & HCQ in RA patients.DOI: 10.15850/amj.v3n3.474

Anonna muricata Linn Leaf Effect in Inhibiting SGPT Elevation Galih Tanaya; Kuswinarti Kuswinarti; R. Nina Susana Dewi
Althea Medical Journal Vol 2, No 1 (2015)
Publisher : Faculty of Medicine Universitas Padjadjaran

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Background: Hepatitis is an infection or inflammation disease of the liver which is caused by virus, toxic substance, and immunological abnormalities. Soursop plant as a medicinal plants is known to have an antioxidant effect and nowadays is used as an alternative drug for hepatitis. One of the methods to assess liver function is to measure the serum Glutamate Piruvate Transaminase (SGPT) level. The purpose of this study was to find the effect of Soursop Leaf in inhibiting the SGPT elevation .Methods: An experimental study was conducted on 25 white male rats of wistar strain in the pharmacology laboratory of Faculty of Medicine, Universitas Padjadjaran during the period of September to October 2012. The rats were divided into 5 groups (group 1 and 2 as control; group 3, 4, and 5 as treatment groups treated by 200, 400, 600 mg/kgbw soursop extract, respectively). The soursop extract was administered to the treatment groups for 8 days. On the 8th day, group 2, 3, 4, and 5 received 1.6 ml CCl410% intraperitoneally. After 18 hours, the mean SGPT levels from all groups were measured. ANOVA test was used to analyze the result.Results : The mean SGPT levels were lower in the 3rd, 4th, and 5th group compared to group 2. There was a significant difference among treatment groups. Group 3 had the most significant result.Conclusion: Soursop leaf inhibits the elevation of SGPT level. Keywords: Hepatitis, SGPT, soursop leaf (Annona muricata) DOI: 10.15850/amj.v2n1.438

Gambaran Penderita Diabetes Mellitus tipe 2 dengan Obat Antidiabetik Oral Grace Y Irene; Kuswinarti Kuswinarti; Maya Kusumawati
Journal of Medicine and Health Vol. 2 No. 5 (2020)
Publisher : Universitas Kristen Maranatha

Uncontrolled hyperglycemia in people with diabetes mellitus can increase the risk of diabetes complications and comorbidities. This study aimed to determine the demographic, clinical, history, complications, and comorbid characteristics of diabetes. The study was conducted with a descriptive method and cross-sectional research design. Data were collected retrospectively using medical record data and using the Finite Population Correction formula with a sample of 115. The results showed the majority of patients were female (67.8%), aged ? 65 years (40.0%), residing in urban (87.6%), high school graduates (35.2%), and unemployed (63.6%). Patients generally have a normal BMI (45.9%) and have several variables that reach the target, namely fasting blood glucose (50.4%), triglycerides (55.3%), and creatinine (69.6%). Patients also had several variables that did not reach the target, namely postprandial 2 hour blood glucose (51.3%), blood pressure (65.8%), total cholesterol (55.6%), HDL cholesterol (54.5%), LDL cholesterol (80.0%), and urea (56.0%). Patients who use oral anti-diabetes generally have used it <5 years (76.3%) and used monotherapy (63.5%). Neuropathy (42.6%) and hypertension (85.9%) were the most common complications and comorbidities of diabetes in this study. Strict glycemic control is an important management for people with diabetes mellitus. Keywords: oral antidiabetic drugs; diabetes mellitus; comorbid

Gambaran Penderita Diabetes Mellitus tipe 2 dengan Obat Antidiabetik Oral Grace Y Irene; Kuswinarti Kuswinarti; Maya Kusumawati
Journal of Medicine and Health Vol 2 No 5 (2020)
Publisher : Universitas Kristen Maranatha

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.28932/jmh.v2i5.1110

Uncontrolled hyperglycemia in people with diabetes mellitus can increase the risk of diabetes complications and comorbidities. This study aimed to determine the demographic, clinical, history, complications, and comorbid characteristics of diabetes. The study was conducted with a descriptive method and cross-sectional research design. Data were collected retrospectively using medical record data and using the Finite Population Correction formula with a sample of 115. The results showed the majority of patients were female (67.8%), aged ? 65 years (40.0%), residing in urban (87.6%), high school graduates (35.2%), and unemployed (63.6%). Patients generally have a normal BMI (45.9%) and have several variables that reach the target, namely fasting blood glucose (50.4%), triglycerides (55.3%), and creatinine (69.6%). Patients also had several variables that did not reach the target, namely postprandial 2 hour blood glucose (51.3%), blood pressure (65.8%), total cholesterol (55.6%), HDL cholesterol (54.5%), LDL cholesterol (80.0%), and urea (56.0%). Patients who use oral anti-diabetes generally have used it <5 years (76.3%) and used monotherapy (63.5%). Neuropathy (42.6%) and hypertension (85.9%) were the most common complications and comorbidities of diabetes in this study. Strict glycemic control is an important management for people with diabetes mellitus. Keywords: oral antidiabetic drugs; diabetes mellitus; comorbid

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