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All Journal Pharmacology and Clinical Pharmacy Research Jurnal Mandala Pengabdian Masyarakat

Idin Sahidin

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Author-ID : 2502862

Medicine & Pharmacology Public Health Social Sciences

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Pemanfaatan Tanaman Obat Keluarga (TOGA) dalam Pencegahan dan Pemulihan Penderita Akibat COVID-19 melalui KKN Tematik Universitas Halu Oleo (UHO) di Kabupaten Kolaka: Utilization of Family Medicinal Plants (TOGA) in the Prevention and Recovery of COVID-19 Sufferers by KKN Tematik of Universitas Halu Oleo (UHO) in Kolaka District Idin Sahidin; Ruslin Ruslin; Sudarman Rahman
Jurnal Mandala Pengabdian Masyarakat Vol. 1 No. 2 (2020): Jurnal Mandala Pengabdian Masyarakat
Publisher : Progran Studi Farmasi STIKES Mandala Waluya

Sufferers of Covid-19 in Southeast Sulawesi Province was continue to increase and until now there is no drug that can kill the virus. Therefore, to prevent, reduce and improve the recovery of Covid-19 cases is done by preventing and reducing the corona virus effects such as fever and shortness of breath. These activities include prevention from outside (external) using disinfectants and antiseptics, as well as prevention from within (internal) through increased immunity. Procurement of disinfectants, antiseptics, immune enhancements is done by utilizing family medicinal plants (TOGA) which can be scientifically justified. The method of this activity includes the socialization of the manufacture and use of disinfectants, handsanitisers and fresh drink made from TOGA in Sub-district of Watubangga, Regency of Kolaka through the Thematic Community Service (KKN) Program of Universitas Halu Oleo. TOGA used consists of turmeric (Curcuma domestica), lime (Citrus aurantifolia), betel (Piper bettle), lemongrass (Cymbopogon citratus), ginger (Curcuma xanthorrhiza) and ginger (Zingiber officinale).

Anti-Inflammatory Activity of Marine Sponge Aaptos sp. to the Plasma Interleukin-1β Level in Wistar Male Rats Adryan Fristiyohadi; Wahyuni Wahyuni; Wa OIL. Kalimin; La OMJ. Permana; Saripuddin Saripuddin; Idin Sahidin
Pharmacology and Clinical Pharmacy Research Vol 4, No 2
Publisher : Universitas Padjadjaran, Indonesia

Inflammation is the response of the body to injury and infection characterized by swelling, heat, pain, and redness. This study aimed to investigate the anti-inflammatory effect of Aaptos sp. ethanolic extract to plasma interleukin (IL)-1β level of Wistar male rats. Aaptos sp. was macerated with 96% ethanol for 3 x 24 hours. Inflammation was induced with administration of 1% carrageenan intraplantarly. Animals were divided into 5 treatment groups, i.e., positive control (diclofenac sodium 3598 ppm); Aaptos sp extract 50 ppm; Aaptos sp extract 100 ppm Aaptos sp extract 200 ppm; and negative control (0.5% Na CMC). After 1 hour, blood was collected and assayed using enzyme-linked immunosorbent assay (ELISA) kit. The results showed that plasma IL-1β levels of animals were decreased by Aaptos sp ethanolic extract. The administration of 50 ppm of extract showed no significant difference (p>0.05) in IL-1β level in first and second hour measurement, but indicated a statistically significant decrease after three hour (p<0.05). The administration of 100 ppm of extract showed no significant difference (p>0.05) in every hour. Significant reduction was observed in the administration of 200 ppm of extract, but the elevation of IL-1β levels was also observed at third hour measurement. In conclusion, ethanolic extract of Aaptos sp. had anti-inflammatory activity and its effective dose was 50 ppm.

Antioxidant Activity of Ethanol Extract of Polygonum pulchrum Blume Asman Sadino; Idin Sahidin; Wahyuni Wahyuni
Pharmacology and Clinical Pharmacy Research Vol 1, No 2
Publisher : Universitas Padjadjaran, Indonesia

The use of antioxidants from natural resources has attracted increasing interest. One of theplant that was empirically used as an antioxidant dietary supplement was Polygonum pulchrumBlume (P. pulchrum Blume). This study aimed to investigate antioxidant activityof roots, stems, leaves and flowers ethanol extract of P. pulchrum Blume. The extract wasobtained by maceration method using ethanol solvent. Antioxidant activity was determinedwith 1,1-diphenyl-picrylhydrazyl (DPPH) method. We found that ethanol extracts of P. pulchrumBlume roots and stems had strong antioxidant activity with IC50 values of 25.2 mg/land 43.26 mg/l, respectively. Ethanol extract of flowers had the weakest antioxidant activitywith IC50 value of 202.96 mg/l. Vitamin C had very strong antioxidant activity with IC50value of 3.97 mg/l. In conclusion, our study revealed that ethanol extract of Polygonumpulchrum Blume roots and stems had strong antioxidant activity. Therefore, P. pulchrumBlume might be potential as an excellent source for natural antioxidant agents for medicalapplication.Keywords: Polygonum pulchrum Blume, DPPH, antioxidant, maceration, ethanol

Ethanolic Extract of Xestospongia Sp. Induces CD4+ and CD14 Cells Levels on Wistar Male Rat Infected with Staphylococcus aureus Adryan Fristiohady; Wahyuni Wahyuni; Muhammad H Malaka; Dewiyanti Madu; Dayatriana Muthalib; Dian Munasari; La Ode MJ Purnama; Baru Sadarun; Muhammad Ilyas; Idin Sahidin
Pharmacology and Clinical Pharmacy Research Vol 5, No 2
Publisher : Universitas Padjadjaran, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15416/pcpr.v5i2.26986

Immunomodulator is a substance that increases or suppresses the immune response through the certain mechanism. The marine sponge Xestospongia sp. has immunomodulatory activity by increasing phagocytic activity. In addition, the phagocytic activity is affected by CD4+ and CD14 cells levels. Thus, this study aims to investigate the effect of Xestopongia sp. extract toward CD4+ and CD14 cells level in model rat. Animals were divided into 4 groups (n=5) and treated for 7 days, as follow: Group I (Ethanolic extract of Xestospongia sp. dose of 300 mg/KgBW); Group II (Ethanolic extract of Xestospongia sp. dose of 400 mg/KgBW); Group III (Phylantus niruri extract); and Group IV (0.5% Na CMC). On day 8, animals were infected with Staphylococcus aureus intraperitoneally. And the blood was collected by cardiac puncture and assayed with ELISA kit CD4 (elabscience®) and ELISA kit CD14 (elabscience®). Ethanolic extract of Xestospongia sp. provided high levels of both CD4+ and CD14 cells (Group II) compared to baseline (Group IV) (p<0.05). Group I provided similar activity to group III (p>0.05) and Group II provided significant activity with higher levels of CD4+ and CD14 cells compared to group III (p<0.05). In conclusion, both doses of Xestospongia sp. extract provide activity as immunomodulator by increasing CD4+ and CD14 cells levels, yet dose of 400 mg/KgBw provides the higher immunomodulatory activity.

Co-Authors Adryan Fristiohady Adryan Fristiyohadi Asman Sadino Baru Sadarun Dayatriana Muthalib Dewiyanti Madu Dian Munasari La Ode MJ Purnama La OMJ. Permana Muhammad H Malaka Muhammad Ilyas Rahman, Sudarman Ruslin Ruslin Saripuddin Saripuddin Siti Helmyati Wa OIL. Kalimin Wahyuni Wahyuni

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