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All Journal Medical Laboratory Technology Journal Jurnal Surya Kencana Dua: Dinamika Masalah Hukum & Keadilan
Rika Yuliwulandari
Unknown Affiliation
Humanities Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Nursing Public Health Social Sciences

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The Use of High Resolution Melting (HRM) Method to Detect rs1800629 of Tumor Necrosis Factor-alpha (TNF-alpha) Gene among Tuberculosis Patients Kinasih Prayuni; Intan Razari; Silviatun Nihayah; Rika Yuliwulandari
Medical Laboratory Technology Journal Vol. 7 No. 1 (2021): June
Publisher : Poltekkes Kemenkes Banjarmasin Jurusan Analis Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (439.767 KB) | DOI: 10.31964/mltj.v7i1.362

Abstract

The rs1800629 polymorphism plays a crucial role in the pathogenesis of infectious and autoimmune diseases. Meanwhile, tuberculosis (TB) remains a health primary infectious disease in Indonesia. The purpose of this study is to evaluate the HRM method in detecting the rs1800629 genotype, in the TNF-α gene’s promoter region, within TB patients. The benefit of this study is to accelerate the detection of rs1800629 with a simple, rapid, and cost-effective method for genotyping and mutation screening that does not include the use of a fluorescent probe. In this experimental study, the rs1800629 genotyped in a total of 25 tuberculosis patients using KAPA HRM kit in MyGo Mini PCR, and all amplified PCR products subsequently dispatched for direct DNA sequencing to Macrogen Inc, South Korea. Based on the results, a 100% concordance find in the genotyping of rs1800629 between HRM and sequencing. The authors provided evidence to use HRM in detecting rs1800629 within the TNF-α promotor region. This application as a genotyping assay in tuberculosis patients is a low-cost, rapid, and accurate detection. However, further studies using the HRM method in case-control samples of tuberculosis are required to evaluate the method’s effectiveness and to obtain more information regarding the genotype’s susceptibility to tuberculosis and its adverse effect treatment, including anti-tuberculosis drug, induced liver injury (AT-DILI), and multidrug-resistant TB (MDR-TB), within the Indonesian population.
PENGEMBANGAN DAN PERLINDUNGAN OBAT/JAMU TRADISIONAL MENUJU INDUSTRI OBAT HERBAL DI JAWA TENGAH DAN JAWA TIMUR Endang Purwaningsih; Rika Yuliwulandari; Soenyono Soenyono; Jarot Tri Bowo Santoso
Jurnal Surya Kencana Dua : Dinamika Masalah Hukum dan Keadilan Vol 6, No 1 (2019): Jurnal Surya Kencana Dua: Dinamika Masalah Hukum & Keadilan
Publisher : Universitas Pamulang

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (714.39 KB) | DOI: 10.32493/SKD.v6i1.y2019.3038

Abstract

Abstrak Pengrajin obat dan jamu tradisional harus diberdayakan dan produknya dilindungi. Tujuan penelitian ini untuk mengidentifikasi dan menganalisis potensi, prospek dan arah pengembangan industri jamu/obat tradisional menuju obat herbal. Metode yang digunakan dalam penelitian ini adalah pendekatan penelitian yang bersifat analisis deskriptif kualitatif dengan memanfaatkan pendekatan participatory (PRA), dan pendekatan sosiologis yuridis. Berdasarkan hasil penelitian disimpulkan bahwa  dewasa ini permasalahan pengusaha jamu/OT belum sampai pada seberapa besar kekuatan motivasi  menuju peningkatan ke herbal terstandar (OHT), namun masih berkutat pada masalah pemenuhan CPOTB demi  lolosnya ijin edar. Perlu uluran kepedulian berbagai pihak mengingat urgensi kepentingan ekonomi (kelanjutan produksi, modal, pemasaran/promosi, kerjasama/networking, manajemen), sosiologi humaniora (pemberdayaan), Kesehatan (higinitas dan uji lab, standarisasi CPOTB), Hukum (regulasi, kebijakan, merek, perlindungan konsumen) Perlu upaya serius untuk jembut bola (disertai pembenahan SDM), pelatihan dan pendampingan dari instansi terkait, yakni   Badan POM (dan Bala Besar POM), Dinas Perindag, Dinas Kesehatan, Dinas Koperasi &UMKM, Ditjen HKI (dan Kanwil), Dinas Pertanian, Kampus, dan peran aktif organisasi GP Jamu (model empowerment, promote and protect bisa diterapkan).Kata Kunci: Potensi, strategi,  jamu, tradisional, herbal
Co-Authors Endang Purwaningsih Intan Razari Jarot Tri Bowo Santoso Kinasih Prayuni Silviatun Nihayah Soenyono Soenyono