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All Journal Journal Pharmaceutical Science and Application (JPSA) Jurnal Dunia Farmasi
Kadek Sutri Ariyanthini
Udayana University
Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Public Health

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Penetapan Kapasitas Penetralan Asam Tablet Antasida (Aluminium Hidroksida dan Magnesium Hidroksida) dengan Metode Titrasi Balik Agus Adi Purnama Putra; Kadek Sutri Ariyanthini
Jurnal Dunia Farmasi Vol 6, No 1 (2021): Edisi Desember
Publisher : Program Studi Farmasi, Fakultas Farmasi dan Kesehatan, Institut Kesehatan Helvetia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33085/jdf.v6i1.5034

Abstract

Pendahuluan: Penyakit asam lambung atau GERD (Gastrophageal Reflux Disease) merupakan penyakit yang disebabkan oleh peningkatan produksi asam lambung akibat kerja lambung yang tidak baik. Antasida mengandung kombinasi zat aktif magnesium hidroksida (Mg(OH)2) dan aluminium hidroksida (Al(OH)3) yang memiliki aktivitas dalam menetralisir kelebihan asam lambung. Tujuan: Untuk mengatahui kapasitas penetralan asam dari tablet antasida guna melihat efektivitasnya sebagai obat penetralisir asam lambung. Metode: Pengujian kapasitas penetralan asam tablet antasida dilakukan dengan metode titrasi balik, dimana kelebihan asan klorida dititrasi dengan natrium hidroksida 0,5 N LV dalam waktu tidak lebih dari 5 menit sampai dicapai pH 3,5 yang stabil (selarna 10 detik sampai 15 detik). Hasil: Berdasarkan hasil perhitungan, kapasitas penetralan asan tablet antasida sebesar 8,15371 mEq. Kesimpulan: Kapasitas penetralan asam tablet antasida yang diuji sudah memenuhi syarat yang tertera dalam Farmakope Indonesia V yaitu asam yang digunakan pada dosis tunggal minimum tidak kurang dari 5 mEq, sehingga tablet antasida efektif digunakan sebagai obat penetralisir asam lambung.
ANTIBACTERIAL ACTIVITY TESTING OF HAND SANITIZER GEL EXTRACT OF CORIANDER (CORIANDRUM SATIVUM L.) SEEDS AGAINST STAPHYLOCOCCUS AUREUS Kadek Sutri Ariyanthini; Elisabeth Angelina; Kadek Nanda Banyu Permana; Fiorenza Jocelyn Thelmalina; I Gusti Ngurah Jemmy Anton Prasetia
Journal Pharmaceutical Science and Application Vol 3 No 2 (2021): Journal Pharmaceutical Science and Application
Publisher : Departement of Pharmacy, Faculty of Mathematic and Natural Science, Udayana University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/JPSA.2021.v03.i02.p06

Abstract

Background: Staphylococcus aureus is a bacterium that causes bacteremia in COVID-19 pneumonitis patients. S. aureus is responsible for 80% of suppurative disease, with the skin surface as its natural habitat. So, maintaining hand hygiene during a pandemic is very important. Currently, people prefer the use of practical hand sanitizers. Most hand sanitizers contain alcohol, which has the potential to irritate. Thus, the active substance of coriander seed extract is used as a substitute for alcohol. Objective: To determine the characteristics of the gel and the concentration of coriander seed extract which gave antibacterial effect against S. aureus. Methods: The resulting hand sanitizer gel was then tested for characteristics and antibacterial activity against Staphylococcus aureus by the Kirby-Bauer diffusion method and analyzed by the One Way Anova-LSD method. Result: The results showed that preparations with concentrations of F1(2%), F2(4%), and F3(6%) respectively had inhibition zones of 1.00 ± 0.82 mm, 5.00 ± 0.41 mm, and 5 .25 ± 1.26 mm. Conclusion: Formulas 2 and 3 were able to inhibit the growth of S. aureus with moderate inhibition category. The hand sanitizer gel meets the requirements for organoleptic tests, pH, homogeneity, dispersibility, and adhesion. However, the viscosity of the preparation did not meet the requirements. Keywords: Coriander Seed Extract, Gel Hand Sanitizer, Antibacterial
Co-Authors Agus Adi Purnama Putra Elisabeth Angelina Fiorenza Jocelyn Thelmalina I Gusti Ngurah Jemmy Anton Prasetia Kadek Nanda Banyu Permana