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All Journal Bioscientia Medicina : Journal of Biomedicine and Translational Research Bioscientia Medicina : Journal of Biomedicine and Translational Research
Desiekawati
Bagian Patologi Klinik Fakultas Kedokteran Universitas Andalas Padang.
Biochemistry, Genetics & Molecular Biology Immunology & microbiology Medicine & Pharmacology Neuroscience

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Mean Platelet Volume and Immature Platelet Fraction as Biomarkers in Differentiating Early-Onset and Late-Onset Neonatal Sepsis Rahmi Dina Indra; Rikarni; Desiekawati; Zelly Dia Rofinda; Dwi Yulia; Elfira Yusri
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 9 No. 5 (2025): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v9i5.1280

Abstract

Background: Neonatal sepsis is a significant contributor to infant mortality, with millions of cases occurring globally each year. It is classified into early-onset neonatal sepsis (EONS), occurring within the first 72 hours of life, and late-onset neonatal sepsis (LONS), occurring after 72 hours. Thrombocytopenia is a common finding in neonatal sepsis, and the degree of thrombocytopenia has been associated with the severity of the disease. Mean platelet volume (MPV) and immature platelet fraction (IPF) are markers of platelet size and immaturity, respectively, and may provide insights into the pathophysiology of sepsis and aid in its diagnosis. Methods: This cross-sectional analytical study was conducted at Dr. M. Djamil General Hospital in Padang, Indonesia, from June to September 2024. The study included 41 neonates diagnosed with sepsis. Complete blood counts were performed using an automated hematology analyzer to determine MPV, IPF, and platelet count. Neonatal sepsis was classified as EONS (within the first 7 days of life) or LONS (from day 8 to 28). Data were analyzed using descriptive statistics and the unpaired t-test. Results: The mean age of the neonates was 11.6 days. There were 19 neonates with EONS and 22 with LONS. The mean MPV was significantly higher in the LONS group (11.7 fL) compared to the EONS group (10.2 fL) (p=0.001). Similarly, the mean IPF was significantly higher in the LONS group (10.9%) compared to the EONS group (7.7%) (p=0.001). There was no significant difference in platelet count between the two groups. Conclusion: MPV and IPF were significantly higher in neonates with LONS compared to those with EONS, suggesting that these parameters may be useful biomarkers for differentiating between the two conditions. Further research with a larger sample size and longitudinal follow-up is needed to confirm these findings and to assess the potential clinical utility of MPV and IPF in the management of neonatal sepsis.
Mean Platelet Volume and Immature Platelet Fraction as Biomarkers in Differentiating Early-Onset and Late-Onset Neonatal Sepsis Rahmi Dina Indra; Rikarni; Desiekawati; Zelly Dia Rofinda; Dwi Yulia; Elfira Yusri
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 9 No. 5 (2025): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v9i5.1280

Abstract

Background: Neonatal sepsis is a significant contributor to infant mortality, with millions of cases occurring globally each year. It is classified into early-onset neonatal sepsis (EONS), occurring within the first 72 hours of life, and late-onset neonatal sepsis (LONS), occurring after 72 hours. Thrombocytopenia is a common finding in neonatal sepsis, and the degree of thrombocytopenia has been associated with the severity of the disease. Mean platelet volume (MPV) and immature platelet fraction (IPF) are markers of platelet size and immaturity, respectively, and may provide insights into the pathophysiology of sepsis and aid in its diagnosis. Methods: This cross-sectional analytical study was conducted at Dr. M. Djamil General Hospital in Padang, Indonesia, from June to September 2024. The study included 41 neonates diagnosed with sepsis. Complete blood counts were performed using an automated hematology analyzer to determine MPV, IPF, and platelet count. Neonatal sepsis was classified as EONS (within the first 7 days of life) or LONS (from day 8 to 28). Data were analyzed using descriptive statistics and the unpaired t-test. Results: The mean age of the neonates was 11.6 days. There were 19 neonates with EONS and 22 with LONS. The mean MPV was significantly higher in the LONS group (11.7 fL) compared to the EONS group (10.2 fL) (p=0.001). Similarly, the mean IPF was significantly higher in the LONS group (10.9%) compared to the EONS group (7.7%) (p=0.001). There was no significant difference in platelet count between the two groups. Conclusion: MPV and IPF were significantly higher in neonates with LONS compared to those with EONS, suggesting that these parameters may be useful biomarkers for differentiating between the two conditions. Further research with a larger sample size and longitudinal follow-up is needed to confirm these findings and to assess the potential clinical utility of MPV and IPF in the management of neonatal sepsis.
Estimated Glomerular Filtration Rate in Pediatric Patients with β-Thalassemia Major: A Single-Center Observational Study at Dr. M. Djamil General Hospital, Padang, Indonesia Vania Ilmi Basri; Husni; Desiekawati
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 8 No. 8 (2024): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v8i8.1057

Abstract

Background: Patients with β-thalassemia major can experience impaired kidney function. Impaired kidney function can occur without symptoms and before serious manifestations appear, so early markers are needed to detect kidney damage. Estimated glomerular filtration rate (eGFR) is a calculation to detect early impairment of kidney function and is widely accepted as an indicator in determining overall kidney function. This study aims to determine the estimated glomerular filtration rate in pediatric patients with β-thalassemia major. Methods: This research is a descriptive research. Data was taken from pediatric patients with β-thalassemia major who received routine transfusions at the pediatric polyclinic of Dr. M. Djamil General Hospital Padang from January 1st – July 31st 2023. Patients underwent hematology examination, serum ferritin, serum creatinine, and estimated glomerular filtration rate calculations using the Schwartz formula. Results: A total of 55 children met the research criteria, consisting of 27 boys (49%) and 28 girls (51%). The median serum creatinine level was 0.5 (0.3-0.8) mg/dL with a range with a mean estimated glomerular filtration rate of 167 mL/minute/1.73m2. Conclusion: Glomerular hyperfiltration occurs in the majority of β-thalassemia major patients, but a decrease in
Estimated Glomerular Filtration Rate in Pediatric Patients with β-Thalassemia Major: A Single-Center Observational Study at Dr. M. Djamil General Hospital, Padang, Indonesia Vania Ilmi Basri; Husni; Desiekawati
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 8 No. 8 (2024): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v8i8.1057

Abstract

Background: Patients with β-thalassemia major can experience impaired kidney function. Impaired kidney function can occur without symptoms and before serious manifestations appear, so early markers are needed to detect kidney damage. Estimated glomerular filtration rate (eGFR) is a calculation to detect early impairment of kidney function and is widely accepted as an indicator in determining overall kidney function. This study aims to determine the estimated glomerular filtration rate in pediatric patients with β-thalassemia major. Methods: This research is a descriptive research. Data was taken from pediatric patients with β-thalassemia major who received routine transfusions at the pediatric polyclinic of Dr. M. Djamil General Hospital Padang from January 1st – July 31st 2023. Patients underwent hematology examination, serum ferritin, serum creatinine, and estimated glomerular filtration rate calculations using the Schwartz formula. Results: A total of 55 children met the research criteria, consisting of 27 boys (49%) and 28 girls (51%). The median serum creatinine level was 0.5 (0.3-0.8) mg/dL with a range with a mean estimated glomerular filtration rate of 167 mL/minute/1.73m2. Conclusion: Glomerular hyperfiltration occurs in the majority of β-thalassemia major patients, but a decrease in
Co-Authors Dwi Yulia Elfira Yusri Husni Rahmi Dina Indra Rikarni Vania Ilmi Basri Zelly Dia Rofinda