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All Journal Jurnal Mangifera Edu Spizaetus: Jurnal Biologi dan Pendidikan Biologi
Nurul Imaniyah AHmad
Universitas Nusa Nipa
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Education Environmental Science Immunology & microbiology Library & Information Science Other

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Molecular Interaction of Chili Compounds (Capsicum annum L) as a COX-2 Inhibitor Yohanes Bare; Nurul Imaniyah AHmad; Yohanes Nong Bunga
Mangifera Edu Vol 6 No 2 (2022): Jurnal Mangifera Edu
Publisher : Universitas Wiralodra

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31943/mangiferaedu.v6i2.124

Abstract

Curly red chili (Capsicum annum L.) is a vegetable that has health benefits. Besides being used as an addictive substance in traditional medicine, Capsicum annum L. is also used for cough treatment, antiseptic, anti-irritant, anti-inflammatory. This research study aims to analyze the physico-chemical and its molecular interactions with COX-2. Capsaicin (CID: 1548943), dihydrocapsaicin (CID: 107982) and homocapsaicin (CID: 6442566) compounds were downloaded from pubchem. While the COX protein (ID: 6cox) from the Protein Data Bank. Molecular interaction and analized by HEX. 8.0.0 and Discovery Studio. The three compounds contained in curly red chilies have unique physico-chemical characteristics. The results of the interaction show that the curly mera chili has a physiological function by inhibiting the performance of COX-2
Molecular Interaction Analysis of Homodihydrocapsaicin as COX-2 Inhibitor Maria Nona Elci Lele; Nurul Imaniyah Ahmad; Yohanes Bare
SPIZAETUS: JURNAL BIOLOGI DAN PENDIDIKAN BIOLOGI Vol 3, No 2 (2022): Spizaetus: Jurnal Biologi dan Pendidikan Biologi
Publisher : Universitas Nusa Nipa

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55241/spibio.v3i2.63

Abstract

Pemanfaatan Capsicum frutescens L sebagai terapi berbagai penyakit  salah satunya inflamasi di dalam tubuh, menjadi fokus saat ini dikarenakan mengandung senyawa bersifat farmakologis seperti homodihydrocapsaicin. Senyawa yang diperoleh homodihydrocapsaicin didownload SMILES dari aplikasi PubChem dengan (CID: 3084336) diunduh dari database PubChem, Protein COX-2 (ID 6cox) diunduh dari Protein Data Bank. Proses preparasi protein dan ligan,  docking, visualisasi maupun analisis mengadopsi penelitian sebelumnya. Tujuan penelitian menganalisis interaksi molekuler senyawa homodihydrocapsaicin sebagai Inhibitor COX-2. Interaksi senyawa homodihydrocapsaicin dan COX-2 membentuk beberapa ikatan residu asam amino yang membentuk ikatan hidrofobik, ikatan hydrogen, dan gaya van der Waals. Energi ikatan yang terbentuk adalah -284.86 cal/mol, sehingga senyawa   homodihydrocapsaicin sebagai terapi inflamasi dengan menghambat mediator inflamasi (COX-2). Capsicum frutescens L. dapat dimanfaatkan sebagai terapi inflamasi didalam tubuh.
Co-Authors Bare, Yohanes Maria Nona Elci Lele Yohanes Nong Bunga