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All Journal Saintika Medika: Jurnal Ilmu Kesehatan dan Kedokteran Keluarga. JOURNAL SCIENTIFIC OF MANDALIKA (JSM)
Muchamad Fadil
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Humanities Health Professions Languange, Linguistic, Communication & Media Medicine & Pharmacology Public Health Other

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PENGARUH EKSTRAK DAUN KERSEN (Muntingiacalabura l.) TERHADAP GAMBARAN HISTOPATOLOGI HEPAR PADA MENCIT (Mus musculus) YANG DIINDUKSI DIET TINGGI LEMAK Muchamad Fadil; Sulistyo Mulyo Agustini; Bragastio Sidharta
Saintika Medika Vol. 12 No. 2 (2016): DESEMBER 2016
Publisher : Universitas Muhammadiyah Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22219/sm.v12i2.5270

Abstract

Dislipidemia merupakan faktor yang paling sering menyebabkan penyakit perlemakan hepar non alkoholik. Daun kersen (Muntingia calabura l.) mengandung antioksidan berupa flavonoid, saponin dan tannin yang dapat menghambat stres oksidatif. Tujuan penelitian ini untuk mengetahui pengaruh ekstrak daun kersen (Muntingia calabura l.) terhadap gambaran histopatologi hepar pada mencit yang diinduksi diet tinggi lemak. Metode yang digunakan adalah True experimental denganpost test only control group design. Sampel dibagi dalam 5 kelompok yaitu kelompok kontrol negatif (K1), kontrol positif (K2), dan 3 kelompok perlakuan yang diberi ekstrak daun kersen (Muntingia calabura l.)dengan dosis 1,5mg/20gBB/hari (K3), 3mg/20gBB/hari (K4), 6mg/20gBB/hari (K5). Data dianalisis menggunakan uji oneway anova, uji post hocbonferroni, dan uji regresi linier...Hasil penelitian menunjukkan bahwa hasil uji one way anova didapatkan pengaruh yang bermakna (p<0,05). Hasil uji one way anovadidapatkan perbedaan yang bermakna antara kelompok kontrol positif dengan kelompok perlakuan (p<0,05). Hasil uji posthoc bonferroni didapatkan perbedaan bermakna (p<0,05) antara masing-masing perlakuan dengan kelompok kontrol. Hasil ujiregresi linier didapatkan adjusted R2=0,511 yang menunjukkan bahwa ekstrak daun kersen memberikan pengaruh sebesar 51%. Pada penelitian ini kelompok perlakuan ekstrak daun kersen dosis 6mg/20gBB/hari memberikan efek perbaikan gambaran histopatologi yang paling baik. Pada penelitian ini disimpulkan pemberian ekstrak daun kersen berpengaruh terhadap perbaikan gambaran histopatologi hepar pada mencit yang diinduksi diet tinggi lemak
Traumatic Optic Neuropathy (TON) yang disertai edema makula dan perdarahan vitreus akibat trauma tumpul berulang pada wajah: case report Muchamad Fadil; Lina Puspita Hutasoit; Jodii Arlan Kurnia
Journal Scientific of Mandalika (JSM) e-ISSN 2745-5955 | p-ISSN 2809-0543 Vol. 7 No. 6 (2026): (in progress)
Publisher : Institut Penelitian dan Pengembangan Mandalika Indonesia (IP2MI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36312/10.36312/vol7iss6pp781-787

Abstract

Traumatic optic neuropathy (TON) is an uncommon complication of trauma that may result in severe and permanent visual impairment. Most cases are associated with major head trauma, whereas TON secondary to assault or apparently minor facial trauma is less frequently reported. We report the case of a 26-year-old man who presented with decreased vision in the left eye accompanied by an early visual field disturbance after sustaining repeated blunt trauma in the form of slaps to the left side of the face. External ocular and anterior segment examinations were unremarkable. Initial visual acuity in the left eye was 1/300, with only hand motion perception. Ocular ultrasonography revealed vitreous hemorrhage, while optical coherence tomography (OCT) demonstrated macular edema. Based on the clinical and ancillary findings, the patient was diagnosed with suspected left traumatic optic neuropathy associated with macular edema and vitreous hemorrhage. The patient was treated with local corticosteroid injection, high-dose oral methylprednisolone followed by tapering, and oral citicoline. On follow-up, visual acuity improved gradually to 5/45, accompanied by improvement of the macular appearance on OCT. This case highlights that apparently mild blunt facial trauma may still be associated with severe visual impairment suggestive of TON, even in the absence of obvious external ocular findings. Comprehensive ophthalmic examination and appropriate ancillary investigations are important to identify associated posterior segment involvement and to monitor clinical outcomes
Co-Authors Bragastio Sidharta Jodii Arlan Kurnia Lina Puspita Hutasoit Sulistyo Mulyo Agustini