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All Journal BIOMA BIOLINK (Jurnal Biologi Lingkungan, Industri, Kesehatan)
I Nyoman Ehrich Lister
Program Studi Pendidikan Dokter, Fakultas Kedokteran, Universitas Prima Indonesia
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Education

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UJI ANTIBAKTERI EKSTRAK BUAH TAKOKAK (SOLANUM TORVUM SWARTZ) TERHADAP PERTUMBUHAN BAKTERI PROPIONIBACTERIUM ACNES Merta Meliana Lajira; I Nyoman Ehrich Lister
BIOLINK (Jurnal Biologi Lingkungan Industri Kesehatan) Vol 6, No 1 (2019): Agustus
Publisher : Universitas Medan Area

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31289/biolink.v6i1.2237

Abstract

Acne vulgaris is a disorder of the skin characterized by changes in blackheads, papules, pustules, and nodules that often occur on the face, shoulders, and back. Propionibacterium acnes is the main habitat that contributes to acne. One of the plants that have an anti-bacterial effect is takokak fruit. This study aims to study the presence or absence of anti-bacterial effects of takokak fruit extract on the growth of Propionibacterium acne bacteria. The test method used is the Diplo disk diffusion method. The fruit was extracted by maceration method using ethanol as a solvent and then diluted using 96% ethanol at a concentration of 25%, 50%, 75%, 100% while the positive control used a clindamycin suspension and negative control of distilled water. The results showed that takokak fruit extract had an antibacterial effect on Propionibacterium acnes with an average diameter inhibition zone of 16.75 mm; 18.3 mm; 18.85 mm; 21.92 mm. Positive control (clindamycin) 37,45; negative control (distilled water) has no value to prevent bacteria.
Efektivitas gel ekstrak etanol daun senggani (Melastoma candidum D. Don.) terhadap diameter luka pasca pencabutan gigi pada tikus putih (Rattus norvegicus) Susanna Halim; Hariyanto Halim; I Nyoman Ehrich Lister; Saipul Sihotang; Ali Napiah Nasution; Ermi Girsang
Bioma : Jurnal Ilmiah Biologi Vol. 10 No. 1: April 2021
Publisher : Universitas PGRI Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26877/bioma.v10i1.6555

Abstract

ABSTRAKDaun senggani (Melastoma candidum D. Don.) mengandung flavonoid, triterpenoid, tanin, saponin, steroid, glikosida, dan fenolik yang berfungsi sebagai antioksidan, antiinflamasi, dan bersifat antifungi, antivirus dan antibakteri. Penelitian ini bertujuan untuk mengetahui konsentrasi ekstrak daun senggani (M. candidum D. Don.) yang memberikan efektivitas terbaik terhadap penyembuhan luka pasca pencabutan gigi pada tikus putih (Rattus norvegicus). Hasil ekstraksi daun senggani diformulasikan dalam bentuk salep dengan konsentrasi 1%, 3%, 5%, dan 10%. Hasil data rata-rata persentase kesembuhan luka yang terlihat dari diameter luka diuji secara statistik menggunakan SPSS versi 23. Hasil analisis pada hari ke-5 menunjukkan salep ekstrak etanol daun senggani (M. candidum D. Don.) konsentrasi 10% memiliki efektivitas penyembuhan luka yaitu sekitar 2,96 mm (p>0,05). Hasil skrining fitokimia daun senggani menunjukkan adanya senyawa metabolit sekunder seperti tanin, saponin, flavonoid, streroid/triterpene, dan glikosida. Kata kunci: ekstrak; gel; luka gigi; Melastoma candidum D. Don.  ABSTRACTThe effectiveness of senggani (Melastoma candidum D. Don.) leaves ethanolic gel extract on wound diameter after tooth extraction in Rattus norvegicus.Senggani (Melastoma candidum D. Don.) contains flavonoid, triterpenoid, tanin, saponin, steroid, glicoside, and phenolic compound which use as antioxidant, antiinflamation, antifungus, antivirus, and antibacteria. This study aims to determine the concentration of senggani (M. candidum D. Don.) leaves extract which gives the best effectiveness on wound healing after tooth extraction in Rattus norvegicus. The results of senggani (M. candidum D. Don.) leaves extraction was formulated in the form of ointments with concentrations of 1%, 3%, 5%, and 10%. The results of the average data on the percentage of wound healing visible from the diameter of the wound were statistically tested using SPSS version 23. The results of the analysis on the day 5 showed the ointment of 10% ethanolic extract of senggani (M. candidum D. Don.) leaves  had an effective wound healing of about 2.96 mm (p> 0.05). Furthermore, the results of phytochemical screening are secondary metabolites such as tanins, saponins, flavonoids, streroids/triterpene and glycosides. Keywords: extract; gel; tooth wounds; Melastoma candidum D. Don.
Co-Authors Ermi Girsang Hariyanto Halim Merta Meliana Lajira Nasution, Ali Napiah Saipul Sihotang Susanna Halim