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All Journal JFL : Jurnal Farmasi Lampung Pharmaceutical And Biomedical Sciences Journal (PBSJ)
Hendri Aldrat
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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AKTIVITAS ANTIINFLAMASI EKSTRAK ETANOL 70% DAUN ASHITABA (Angelica keiskei) SECARA IN VIVO DENGAN PENGINDUKSI KARAGENAN Haka As'ada; Yardi Saibi; Hendri Aldrat
JFL : Jurnal Farmasi Lampung Vol. 7 No. 2 (2018): JFL: Jurnal Farmasi Lampung
Publisher : Fakultas MIPA Universitas Tulang Bawang Lampung

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (408.56 KB) | DOI: 10.37090/jfl.v7i2.56

Abstract

Ashitaba leaves (Angelica keiskei) or also known as tommorow's leaf is plant that known to have various health benefit, one of them is as an anti-inflammatory activity. The anti-inflammatory activity of ashitaba leaves has been known through in vitro assays. This study aims to determine the anti-inflammatory activity of 70% ethanol extract of ashitaba leaves through in vivo assay. Anti-inflammatory activity was performed on white male rat of Sprague dawley strain with induction method of edema on rat's foot using 1% carrageenan 0.2 ml. Rats were divided into 5 groups. The negative control group was given a 0.5% Na-CMC suspension, a positive control group was given sodium diclofenac suspension of 5.14 mg / kgBW, and the test group was given 70% ethanol extract of ashitaba leaves at a dose of 1000; 2000; and 4000 mg / kgBW suspended in 0.5% Na-CMC. The results showed that in that dose range the 70% ethanol extract of ashitaba leaves had anti-inflammatory activity that did not depend on the dose. Percentage of edema of 70% ethanol extract of ashitaba leaves dose 1000; 2000; 4000 mg / kgBB was significantly different with negative control (p ≤ 0,05) and had percentage of edema inhibition respectively 83,95%, 79,01%, and 80,25%. The results of this study showed that 70% ethanol extract of ashitaba leaves have anti-inflammatory activity. Keywords: Ashitaba, Angelica keiskei, tommorow's leaf, anti-inflammatory, carrageenan.
Penggunaan Obat Herbal pada Responden COVID-19 yang Menjalani Isolasi Mandiri Mita Restinia; Hendri Aldrat; Alia Dening Pangestuti; Ahmad Musir
Pharmaceutical and Biomedical Sciences Journal (PBSJ) Vol 5, No 2 (2023)
Publisher : UIN Syarif Hidayatullah Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/pbsj.v5i2.32294

Abstract

COVID-19 is an infectious disease caused by spreading the coronavirus worldwide. In Indonesia, COVID-19 patients with mild symptoms can undergo independent isolation at home. The public widely uses herbal medicines in the treatment of COVID-19. A non-experimental cross-sectional study was performed to identify the profile of the use of herbal medicines by COVID-19 respondents during independent isolation in South Tangerang. The sampling technique conducted purposive sampling on 96 respondents who met the inclusion criteria. The instrument used is a questionnaire with close-formatted and open-ended questions. Questionnaires were distributed online from March to May 2022. The most used herbal medicines were honey (85.4%), ginger (52.1%), propolis (35.4%), turmeric (32.3%) and garlic (26%). The reason respondents used herbs because they were made from natural ingredients (84.4%), the method of use was boiled or brewed (58.3%), information on the use of herbal medicines was obtained from the family (63.5%), the source of obtaining herbal medicines was sent by relatives/family/friends (69.8%), the duration of using herbal medicines is 1-7 days (39.6%), the time to use herbal medicines was generally in the morning (49%), and the cost of herbal medicines is IDR 100,000 - 500,000 (44.8%). Through this research, it can be concluded that South Tangerang City's people still use herbal medicines as an alternative treatment while infected with COVID-19. Therefore, further education on the safety and maximum use of herbal medicines is required.
Co-Authors Ahmad Musir Alia Dening Pangestuti Haka As'ada Mita Restinia Vidia Arlaini Anwar Yardi Yardi Yoga Sutrisno