Imam Effendi
Faculty of Medicine University of Indonesia, Jakarta

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PENGEMBANGAN ALAT SKRINING UNTUK HIPERTENSI Harahap, Heryudarini; Widodo, Yekti; Muljati, Sri; Triwinarto, Agus; Effendi, Imam
GIZI INDONESIA Vol 33, No 2 (2010): September 2010
Publisher : PERSATUAN AHLI GIZI INDONESIA

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Abstract

THE DEVELOPMENT OF SCREENING TOOL FOR HYPERTENSIONThe increasing prevalence of hypertension is an important public health problem contributing to significant excess disease and mortality. The risk factors of high blood pressure were smoking, sex, age, consumption, activity, obesity, and heredity. Studies showed that subjects didn’t aware about their blood pressure as well as subjects’ knowledge about risk and symptom of hypertension was not good. Hypertension prevention can be done by giving screening tools to detect the blood pressure as well asgiving information about risk and symptom of hypertension. The objective of the study was to develop screening tool to detect hypertension. A cross-sectional survey was conducted in Bogor, North Jakarta and Tangerang district. Blood pressure was collected using spyhgmanometer. The JNC 7 was used to classify of hypertension. Screening tool and leaflet was developed based on the result of Basic Health Research data set as well as literature study. The study had three activities that were focus group discussion, validity and reliability, as well as screening tool trial. Results: Validity test showed that over 17 questions only 6 questions were valid (p<0,05, r = 0,176). After re-construction of screening tool questions then validity test was done again. Over 15 questions, 12 was valid (p<0,05, r = 0,07).Eventhough 3 questions were not valid that questions were still included in that screening tools. Reliabilty of screening tool was realiable (α Cronbach’s = 0.586). The sensitivity (Se) and Specificity (Sp) of subjects that had been have 7 scores or higher was had Se 61.6 and 64.1 Sp respectively. Conclusion: This study implies that hypertension screening tool can be used as screening tool to detect hypertension.Keywords: hypertension, obesity, sensitivity, screening tool, specificity
THE ROLE OF NEOPTERIN AS A NOVEL BIOMARKER FOR REDUCED KIDNEY FUNCTION: A COMMUNITY BASED STUDY Widiana, G Raka; Suwitra, K; Effendi, Imam
journal of internal medicine Vol. 12, No. 2 Mei 2011
Publisher : journal of internal medicine

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Cardiovascular disease is a major complication for patents with reduced kidney function. Neopterin is well known as abiomarker for cardiovascular disease, however it is not clear whether it is associated with reduced kidney function. Study wascarried out in a Legian Kuta village a tourist town in Bali. Samples were underwent a series of interview, physical examinationand were taken blood samples for neoperin and creatinine tests. Neoptein concentrations were tested for its normal distributionand associated with C-G formula for estimated glomerular filtration rate. Cut-off value for prediction of reduced renal functionwas rested using ROC curve, and calculated for sensitivity, specificity.Seventy nine samples were selected through cluster random sampling from 284 residents (177 males and 107 females)with age 46 ± 10 years, body weight 67 ± 13 kg and height 162 ± 9 cm. It was shown that neopterin concentration was normallydistributed (K-S Z = 1.175, p = 0.126), with mean 6.66 ± 3.35 ng/ml and e-GFR was 89 ± 25 ml/mnt. There was significantnegatively correlation between neopterin concentrations and e-GFR (R = -0.26, Rsq = 0.068, p = 0.021), using regressionequation it was revealed that every 1 unit increased of neopterin concentrations produce 1.42 decrease of e-GFR. Using ROCcurve, neopterin was accurately detect reduced kidney function defined as e-GFR of 60 ml/mnt or less (AUC = 0.88; 95%CI0.74 to 1.00; SE = 0.07; p = 0.02). Using 7.46 ng/ml as cut-off value for normal neopterin concentrations, it was showed thatsensitivity and specificity were 100% and 72% to detect the presence of reduced kidney function, consecutively. Neopterin maybe used as a novel biomarker for reduced kidney function, for its role in the pathogenesis of cardiorenal syndrome in generalpopulation.