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All Journal Pharmacon Jurnal Litbang Provinsi Jawa Tengah Abdi Geomedisains Usadha Journal of Pharmacy
Maryati Maryati
Universitas Muhammadiyah Surakarta
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Dentistry Earth & Planetary Sciences Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health Social Sciences

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Journal : Pharmacon

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Aktivitas Sitotoksik Ekstrak Heksan, Ekstrak Etil Asetat, Ekstrak Etanol Buah Mengkudu (Morinda citrifolia L ) Terhadap Sel T47D Maryati Maryati; Ahmad Novian Nur Anas; Muhammad Nur Khairudin
Pharmacon: Jurnal Farmasi Indonesia Vol 17, No 1 (2020)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/pharmacon.v17i1.10761

Abstract

Noni fruit (Morinda citrifolia L) is one of the natural ingredients commonly used as traditional medicine to overcome various diseases, such as cancer. Noni fruit contains anthraquinone and coumarin which have anticancer effects. This study aims to determine the cytotoxic effects of n-hexane, ethyl acetate and ethanol extract of noni fruit and to determine the presence of anthraquinone and coumarin in the extract. Extraction was carried out by maceration method using n-hexane, followed by ethyl acetate and ethanol. The cytotoxic activity on T47D cells was carried out by the MTT method. The presence of anthraquinone and coumarin was identified using thin layer chromatography (TLC). Results showed that n-hexane extract had moderate cytotoxic effect on T47D cells with IC50 value of 582.13 ± 61.64 µg/mL, while the ethanol and ethyl acetate extract did not have cytotoxic effect on T47D cells. TLC results indicated that n-hexane extract of noni fruit contains anthraquinone and coumarin.
Aktivitas Sitotoksik dan Antiproliferasi Fraksi n-Heksan Biji Al-pukat (Percea americana Mill.) Terhadap sel T47D Juwita Rahmawati; Maryati Maryati
Pharmacon: Jurnal Farmasi Indonesia Vol 18, No 1 (2021)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/pharmacon.v18i01.14271

Abstract

Avocado plants are widely used as traditional medicine in Indonesia. This research aimed to determine the cytotoxic and antiproliferation activity of avocado seed extract and fractions on the T47D breast cancer cell line. Extraction was done by maceration method using 96% ethanol, then fractionation was done by liquid-liquid partition using n-hexane, chloroform, and ethyl acetate. Cytotoxic and antiproliferation tests were done by the MTT method. Apoptosis activity was investigated by the double staining method, using acridine orange-propidium iodide as a staining reagent. Results showed that the n-hexane fraction of avocado seed had a cytotoxic activity with IC50 27.9 µg/mL. N-hexane fraction of avocado seed inhibited proliferation and induced apoptosis of T47D cell line.
Cytotoxic and Antiproliferation Activity of n-Hexane Fraction of Avocado seed (Persea americana Mill.) on MCF7 cell Juwita Rahwawati; Maryati Maryati; Ratna Yuliani
Pharmacon: Jurnal Farmasi Indonesia Vol 19, No 1 (2022)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/pharmacon.v19i1.18274

Abstract

Avocado seeds, which often end up as food waste, have many health benefits, including anticancer activity. This study aimed to determine the potential cytotoxic activity of avocado seeds against breast cancer cells, MCF7. Avocado seeds were macerated with 96% ethanol and fractionated with n-hexane, chloroform, and ethyl acetate as solvents. Cytotoxic activity of the extract and fractions was tested using the MTT method, while antiproliferation activity and apoptosis of the n-hexane fraction were tested using the doubling time and double staining methods, respectively. The selectivity of the n-hexane fraction was also determined. The results showed that the extract and n-hexane fraction of avocado seeds had cytotoxic activity on MCF7 with IC50 values of 211.2±25 and 47.87±1.5 µg/mL, respectively. The cytotoxic activity of the n-hexane fraction was selective (Selectivity Index = 4.73). The fraction can extend the doubling time to 76.54-77.41 hours. The double staining test results showed red fluorescence in the cells, indicating the apoptosis of MCF7 cells. The n-hexane fraction of avocado seed extract has the potential to be developed as an anticancer therapeutic agent. 
Co-Authors Ahmad Novian Nur Anas Ahsana Nadia Zahra Alifiyah Sugihartini Andika Permana Ashari Wahyu Budi Aji Dolita Khurfia Janna Farida Nurcahyani Gunawan Setiyadi Hevi Mifta Kumalasari Hidayah Karuniawati Ichsanudin Febrianto Ismi Dwi Widayanti Ismi Dwi Widyanti Juwita Rahmawati Juwita Rahwawati Kusmiyati Kusmiyati Manira Zahratunisa Muhammad Nur Khairudin Ratna Yuliani Sakinatul Hayati Septi Fatmawati Suprapto Suprapto Yunika Isnanda Pratiwi