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All Journal Jurnal Ilmiah Pharmacy JOURNAL OF Pharmacy and Tropical Issues
Densi Selpia Sopianti
Sekolah Tinggi Kesehatan Al-Fatah Bengkulu
Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology

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EVALUASI ANTIOKSIDAN DARI LULUR BODY SCRUB EKSTRAK RUMPUT LAUT MERAH (Gelidium sp) Densi Selpia Sopianti
Jurnal Ilmiah Pharmacy Vol 9, No 1 (2022)
Publisher : Sekolah Tinggi Kesehatan Al-Fatah Bengkulu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52161/jiphar.v9i1.408

Abstract

Kulit merupakan anggota tubuh yang terluar dan langsung bersentuhan dengan lingkungan, paparan sinar matahari dan perubahan iklim membuat kulit kita menjadi kusam, layu dan keriput. Salah satu penangananannya yaitu diperlukanlah antioksidan dari luar, salah satu tanaman yang mengandung senyawa antioksidan yaitu rumput laut merah (Gelidium sp), tanaman tersebut yang diolah menjadi sediaan lulur body scrub. Penelitian ini bertujuan untuk membuat sediaan lulur body scrub ekstrak rumput laut merah (Gelidium sp) yang sesuai standar dan evaluasi sediaan sebagai antioksidan. Metode pembuatan sediaan dengan memvariasikan konsentrasi dari ekstrak rumput laut merah yaitu 5%, 10%, dan 15% kemudiaan dilakukan uji sifat fisik sediaan lulur Body scrub berupa uji organoleptis, uji homogenitas, uji pH, uji daya lekat, uji daya sebar dan aktivitas antioksidan dengan menggunakan metode DPPH secara spektrofotometri pada panjang gelombang 517. Hasil menunjukkan bahwa Ekstrak rumput laut merah dapat diformulasikan sebagai sediaan lulur body scrub. Namun terjadi ketidak stabilan pada uji organoleptis dan uji daya sebar. Aktivitas antioksidan dengan nilai IC50 pada formula 1 (393,93 μg/ml), formula 2 (555,47 μg/ml) dan formula 3 (225,17 μg/ml). Formula yang memiliki aktivitas antioksidan tertinggi yaitu formula 3 dengan nilai IC50 225,17 μg/ml.
Studi komparatif skrining fitokimia dan aktivitas antibakteri ekstrak daun suji (Dracaena angustifolia) terhadap Escherichia coli Densi Selpia Sopianti; Aziza Oktarina; Varina Theodora Pratiwi; Elly Mulyani; Gina Lestari
JOURNAL OF Pharmacy and Tropical Issues Vol. 6 No. 3 (2026): July Edition 2026
Publisher : Indonesian Public Health-Observer Information Forum (IPHORR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56922/pti.v6i3.3790

Abstract

Background: Pathogenic bacterial infections, particularly gastroenteritis caused by Escherichia coli, remain a major global health challenge due to escalating antibiotic resistance. Dracaena angustifolia (Suji leaf) contains diverse bioactive secondary metabolites that offer potential antimicrobial properties, making it a viable natural alternative for exploration. Purpose: To analyze the phytochemical screening profile using Thin Layer Chromatography (TLC) and evaluate the comparative antibacterial efficacy of Dracaena angustifolia leaf ethanol extract against the growth of Escherichia coli in vitro. Method: This experimental laboratory study used a 96% ethanol maceration method to extract compounds from Suji leaves. Phytochemical screening was conducted via conventional tube reagents and confirmed using TLC (Silica Gel GF254) to determine Rf values. Antibacterial activity against Escherichia coli was evaluated using the disk diffusion method with extract concentrations of 20%, 60%, and 80% w/v across three replications. Ciprofloxacin and 10% DMSO served as positive and negative controls, respectively. Data were statistically analyzed using One-Way ANOVA and the Tukey HSD post-hoc test (p<0.05) Results: The maceration process resulted in a yield of 13.47%. Phytochemical screening confirmed the presence of alkaloids (Rf=0.92), saponins (Rf= 0.71), and tannins (Rf= 0.65). The mean inhibition zone diameter increased dose-dependently: 11.23 mm (20%), 13.83 mm (60%), and 14.61 mm (80%). Statistical analysis showed that the differences among the extract concentration groups were not significant (p<0.05). However, a highly significant difference was observed when comparing all extract concentrations to ciprofloxacin (p=0.000). Conclusion: The ethanol extract of Dracaena angustifolia leaves possesses alkaloid, saponin, and tannin compounds that exhibit a strong capacity to inhibit Escherichia coli. While higher concentrations widen the inhibition zone, the structural increase is not statistically significant, and its overall efficacy remains lower than the standard antibiotic ciprofloxacin.   Keywords: Antibacterial; Dracaena Angustifolia; Escherichia Coli; Phytochemical Screening; Thin Layer Chromatography.
Co-Authors Aziza Oktarina Gina Lestari Mulyani, Elly Varina Theodora Pratiwi