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All Journal journal of internal medicine Jurnal Ilmu Kedokteran dan Kesehatan Bioscientia Medicina : Journal of Biomedicine and Translational Research
I Wayan Eka Saputra
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Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

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SEORANG PENDERITA HEPATITIS KRONIK B DAN C DENGAN MUTASI PADA GEN P53 KODON 249 PADA JARINGAN HATI Eka Saputra, I Wayan; Gunawan, Stephanus; Muttaqin, Zainul; Soemoharjo, Soewignjo
journal of internal medicine Vol. 8, No. 2 Mei 2007
Publisher : journal of internal medicine

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (426.849 KB)

Abstract

Role of gene P53 as a tumor suppressor gene in generating primary liver cancer is very important primarily in cellgrowth regulation and apoptosis. By using AS-PCR method, the gene mutation can be recognized. It has been reported a chronichepatitis B and C case with experiencing mutation of gene P53 Codone 249 in liver tissue of a 33 years old male with anti HCVpositive, HBsAg positive, on the liver biopsy indicated of chronic hepatitis without cirrhotic features and malignancy signs. OnAS-PCR examination found mutation on gene P53 codone 249. This finding was expected to be an early warning sign foroccurrence of primary liver cancer, so that, early intervention could be performed.
HUBUNGAN GASTROESOPHAGEAL REFLUX DISEASE DENGAN KUALITAS TIDUR PADA PASIEN RAWAT JALAN DI RSUD SANJIWANI GIANYAR I Gusti Lanang Rama Dwi Suputra; I Wayan Eka Saputra
Jurnal Ilmu Kedokteran dan Kesehatan Vol 10, No 2 (2023): Volume 10 Nomor 2
Publisher : Prodi Kedokteran Fakultas Kedokteran Universitas Malahayati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/jikk.v10i2.9378

Abstract

Gastroesophageal reflux disease (GERD) adalah suatu penyakit yang ditandai dengan naiknya asam lambung ke kerongkongan yang menyebabkan keluhan heartburn dan regurgitasi. Prevalensi GERD di seluruh dunia bervariasi sekitar 13%. GERD sering dikaitkan dengan penurunan kualitas tidur yang berakhir dengan penurunan produktivitas di siang hari. Refluks asam lambung di malam hari berkaitan dengan berbagai komplikasi seperti barret’s esofagus dan adenokarsinoma esofagus. Penelitian ini bertujuan untuk mengetahui hubungan antara GERD dan kualitas tidur pasien dengan menggunakan desain studi cross sectional dan dianalisis menggunakan uji Chi Square. Sampel dipilih secara consecutive sampling sebanyak 104 pasien di Rumah Sakit Umum Daerah Sanjiwani Gianyar, Bali, Indonesia dari bulan Mei 2022 hingga Juli 2022. Instrumen penelitian berupa pittsburgh sleep quality indeks (PSQI) dan GERD-questionnaire (GERD-Q). Hasil penelitian menunjukkan p value=0,002 (p< 0.05). Simpulan, GERD memilki hubungan terhadap kualitas tidur pasien rawat jalan di RSUD Sanjiwani Gianyar secara signifikan. Pemberian proton pump inhibitor (PPI) disertai penerapan gaya hidup yang sehat dapat meperbaiki keluhan GERD dengan atau tanpa gangguan tidur.
Analysis of Risk Factors and Predictors of Endoscopic Findings in Patients with Gastrointestinal Disorders: A Single Center Observational Study at Sanjiwani General Hospital, Gianyar, Bali, Indonesia Dwi Putri Anjani, I Gusti Agung; I Wayan Eka Saputra
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 8 No. 10 (2024): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v8i10.1084

Abstract

Background: Gastrointestinal disorders are a common health problem in Indonesia. Endoscopy is an important procedure in diagnosing and managing this disorder. This study aims to analyze risk factors and predictors of endoscopic findings in patients with gastrointestinal disorders at regional hospitals in Bali. Methods: This research is an analytical observational study with a cross-sectional design. The research subjects were patients with gastrointestinal disorders who underwent endoscopy at regional hospitals in Bali during the period January 2022 to December 2023. Data was collected through medical records and interviews. Data analysis was carried out using the Chi-square test and logistic regression. Results: A total of 1074 patients were included in this study. The mean age of patients was 45.3 years (SD 15.2). The most common endoscopic finding was gastritis (35.2%), followed by gastric ulcer (15.8%) and esophagitis (12.4%). Risk factors that were significantly associated with endoscopic findings were age > 45 years (OR 1.78; 95% CI 1.23-2.57), male gender (OR 1.54; 95% CI 1.11- 2.14), history of smoking (OR 2.31; 95% CI 1.65-3.24), and history of use of non-steroidal anti-inflammatory drugs (NSAIDs) (OR 1.98; 95% CI 1.39-2.82). Conclusion: Age > 45 years, male gender, smoking history, and history of NSAID use are risk factors that are significantly associated with endoscopic findings in patients with gastrointestinal disorders at regional hospitals in Bali.
Co-Authors A.A. Ketut Agung Cahyawan W Dwi Putri Anjani, I Gusti Agung I Gusti Lanang Rama Dwi Suputra Soewignjo Soemoharjo Stephanus Gunawan