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All Journal Jurnal Ilmu Kefarmasian Indonesia Al-Mujahidah : Jurnal Pendidikan Guru Madrasah Ibtidaiyah Jurnal Farmasi Galenika
Elin Julianti
Sekolah Farmasi, Institut Teknologi Bandung
Biochemistry, Genetics & Molecular Biology Education Health Professions Medicine & Pharmacology Public Health

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Optimasi Formula Lipid Nanostruktur dengan Pentarget Manosa sebagai Sistem Penghantaran Rifampisin Tri Suciati; Nurani Istiqomah; Benny Permana; Elin Julianti; Marlia Singgih Wibowo; Titah Yudistira; Yani Triyani
JURNAL ILMU KEFARMASIAN INDONESIA Vol 17 No 2 (2019): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1017.477 KB) | DOI: 10.35814/jifi.v17i2.568

Abstract

Limited accumulation of anti-tuberculosis drugs in macrophages become a barrier to the success of latent tuberculosis therapy. The purpose of this study is to develop a D-mannose modified nanoparticle formula as a targeting agent to the mannose receptors to increase the internalization of rifampicin into macrophages. D-mannose was conjugated with chitosan using an amine reducing agent. Chitosan-D-mannose conjugate was characterized using FTIR. Subsequently, the conjugate was adsorbed onto the nanostructured lipid carrier (NLC) electrostatically. The NLC formula consisted of an ethyl acetate solution of solid-liquid lipid blend and rifampicin and an aqueous solution of chitosan-D-mannose conjugate, which were emulsified using polysorbate 80. Solidification of the NLC-chitosan-mannose nanoparticles was carried out by ionotropic gelation and solvent evaporation. The nanoparticle formula was optimized using Box-Behnken design. The formation of chitosan-D-mannose conjugate was shown by the change of the amide band wave number and the Schiff base formation of the FTIR spectra. The optimum formula of nanoparticles had a diameter of 766.1 ± 57.56 nm with a polydispersity index of 0.32 ± 0.02, encapsulation efficiency of 91.54 ± 0.18% and drug loading of 36.62 ± 0.07%. Rifampicin was released from the nanoparticles at pH 5.2 or 7.4 with a similar rate. This D-mannose modified NLC formula has the potential to be further developed as an intracellular antibiotic targeting to macrophages.
PEMBENTUKAN ZAT WARNA Monascus purpureus DENGAN LIMBAH AMPAS KELAPA SEBAGAI SUBSTRAT DAN UJI AKTIVITASNYA TERHADAP Escherichia coli dan Candida albicans Elin Julianti; Anna Yuliana; Marlia Singgih
JURNAL FARMASI GALENIKA Vol 5 No 2 (2018): Jurnal Farmasi Galenika Volume 5 No. 2, 2018
Publisher : Universitas Bhakti Kencana

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Abstract

Telah dilakukan penelitian pembentukan zat warna Monascus purpureus hasil fermentasi padat dengan dua variasi sampel limbah ampas kelapa sebagai substrat. Dilakukan pengukuran pembentukan zat warna dengan cara mengekstraksi sampel menggunakan etanol 95% pada fermentasi hari ke-7 dan ke-14 dilanjutkan dengan pengujian kromatografi lapis tipis menggunakan pengembang etanol:etilasetat (7:3). Serapan zat warna diukur dengan spektrofotometer UV-Vis pada panjang gelombang 400, 406, 498, 500, 511 dan 512 nm. Hasil menunjukkan serapan zat warna mengalami peningkatan dengan rentang serapan antara 0,128–0,269 dan 0,212-1,019 dan Sampel A menunjukkan serapan lebih tinggi dibandingkan Sampel B. Pengujian aktivitas antimikroba ekstrak zat warna ke dua sampel dilakukan terhadap Escherichia coli dan Candida albicans menunjukkan adanya aktivitas antimikroba. Kesetaraan aktivitas berdasarkan kurva baku Tetrasiklin HCl terhadap Escherichia coli dan kurva baku Nistatin terhadap Candida albicans menunjukkan ekstrak zat warna Monascus purpureus dengan konsentrasi 100% pada Sampel A lebih besar dibandingkan Sampel B. Dengan dua variasi waktu yang berbeda hari ke-7 dan hari ke-14 Sampel A mempunyai aktivitas kesetaraan konsentrasi 1,41% dan 4,13% Tetrasiklin HCl serta 0,81% dan 1,38% Nistatin. Sampel B pada hari ke-7 dan hari ke-14 mempunyai aktivitas kesetaraan konsentrasi 1,02% dan 2,44% Tetrasiklin HCl serta 0,79% dan 1,20% Nistatin.
ANALISIS PENGGUNAAN MEDIA GUTA (GAME ULAR TANGGA) DALAM PEMBELAJARAN MATEMATIKA KELAS V SD Elin Julianti
Al-mujahidah Vol 5 No 2 (2024): Oktober
Publisher : Institut Agma Islam Hamzanwadi NW Lombok TImur

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51806/al-mujahidah.v5i2.132

Abstract

Some errors that occur in the learning process are the teacher's lack of effectiveness in using learning media. This results in learning mathematics becoming boring and not of interest to students. So here it is necessary to apply a variety of learning media in mathematics learning, such as the use of snakes and ladders media in mathematics learning. This research aims to analyze and describe the use of Snakes and Ladders Media in mathematics learning. This research method uses a qualitative descriptive method with the variable in this research being the scope of mathematics learning content. Documents used include teacher books and student books. The methods used in collecting data are observation, experimentation and pretest-posttest techniques. The data from this research were then analyzed using qualitative descriptive methods. The research subjects were objects, namely the snakes and ladders game media and 5th grade elementary school mathematics learning student books. The research subjects of the informants were: Principal, Class 5 Teacher and 30 Class 5 students. With pretest scoring results of 23% before using the media and post test scoring results of 50% after using the media, so there was an increase in scoring results of 27%.
Co-Authors Anna Yuliana, Anna Benny Permana Marlia Singgih Marlia Singgih Wibowo Nurani Istiqomah Titah Yudistira Tri Suciati Yani Triyani