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All Journal As-syifaa Jurnal Farmasi

Safriani Rahman

Fakultas farmasi Universitas Muslim Indonesia Makassar

Author-ID : 2644954

Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology

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UJI EFEK ANTIINFLAMASI EKSTRAK ETANOL DAUN SIRSAK (Annona muricata Linn.) TERHADAP MENCIT (Mus musculus) JANTAN YANG DIINDUKSI DENGAN KARAGEN Rahmawati Rahmawati; Safriani Rahman; Mustari Mustari
As-Syifaa Jurnal Farmasi Vol 4, No 1 (2012): AS-SYIFAA Jurnal Farmasi
Publisher : Fakultas Farmasi UMI

The research about aniinflammatory effect of Sirsak leaves (Annona muricata Linn.) ethanolic extract in male mice (Mus musculus) was conducted, the aim to assay the anti-inflammatory effect of Sirsak leaves done extract based on decrease in oedema volume of foot palm male mice. It was used 15 male mices that evaluated and divided into 5 groups that each group has 3 mices given extract in dose 0f 0,182 g/kgBB, 0,546 g/kgBB and 0,91 g/kgBB, one group as the compore which administered diclofenac sodium, one negative control group which administered 1% Na.CMC. induction carried out by injection 1% w/v carrageen 0,05 ml subcutan in the feet palm of mice. One hour later each group administered the teste preparation orally 1 ml/30 gBW. Group 1 to 3 the series dose of the extract 0,182 g/kgBB, 0,546 g/kgBB and 0,91 g/kgBB. Group 5 diclofenac sodium suspension. The measurement of oedema volume carried out prior and after administration of the tested preparation 0, 30, 60, 90, and 120 minutes. The data correlation between oedema versus time analysed value with use SPSS 20.Result indicated variaties with ethanolic Extract of Sirsak leaves have the effect antiinflamatory at dose 0,182 g/kgBB, 0,546 g/kgBB, dan 0,91 g/kgBB and not differ the reality by Natrium Diklofenak.Keywords : Inflamation, Anona muricata’s leaf, Carageen.

UJI TOKSISITAS EKSTRAK ETANOL BUAH MERAH (Pandanus conoideus Lam) ASAL MANOKWARI PAPUA BARAT DENGAN METODE BRINE SHRIMP LETHALITY TEST Safriani Rahman; Riyan Wulansari Puspa Seruni
As-Syifaa Jurnal Farmasi Vol 3, No 2 (2011): AS-SYIFAA Jurnal Farmasi
Publisher : Fakultas Farmasi UMI

A research on Toxicity assay of Extract Ethanol Red Fruit (Pandanus conoideus Lam) upon Brine Shrimp Lethality Test which intended to know the toxic effect of Red Fruit and supposed to determine Lc50 of the Red fruit by method Brine Shrimp Lethality Test. The ethanol ekstrak, was made in various concentration 10, 100, 1000 µg/ml. Mean while, for negative control was seawater which made by the same concentration. In each concentration has put in 10 brine shrimp. Each concentration has put 1 drop of yeast extract as source of food. The volume is added to 10 ml, observation is done after 24 hours treatment. Observation result in dead brine shrimp data. From the counted of probit analysis method obtained Lc50 value was that 52,844 ± 25,679 µg/ml. Mean while in negative compare there were not brine shrimp killed. Key words : Pandanus conoideus Lam, Brine Shrimp Lethality Test, Toxicity assay

UJI EFEK ANTIINFLAMASI EKSTRAK n-HEKSAN DAUN BERUWAS LAUT (Scaevola taccada (Gaertn.) Roxb) PADA MENCIT JANTAN (Mus musculus) YANG DIINDUKSI DENGAN KARAGEN Sitti Amirah; Rahmawati Rahmawati; Safriani Rahman; Franita Achmad
As-Syifaa Jurnal Farmasi Vol 6, No 2 (2014): AS-SYIFAA Jurnal Farmasi
Publisher : Fakultas Farmasi UMI

This research about antiinflammation effect from n-hexane extract of Beruwas Laut leaves (Scaevola taccada (Gaertn.) Roxb.) in male mice (Mus musculus) was conducted, the aim was assay the antiinflammation effect of Beruwas Laut leaves done extract based on decrease in edema volume of foot palm male mice. This research using 15 male mice that evaluated and divided into 5 groups that each group has 3 mice. In group I, diclofenac sodium as the compare administrated. In groups II, III, dan IV, n-hexane Extract of Beruwas Laut leaves in concentration of 2,5%, 5% and 7,5% administrated. In group V, 1% Na-CMC as negative control administrated. Induction carried out by injection 1% w/v carrageen 0,1 ml subcutan on the feet palm of mice. One hour later each group administered the preparation test 1 ml/30 gBW orally. The measurement of edema volume carried out prior and after administration of the tested preparation 0, 30, 60, 90, and 120 minutes. The data correlation between induction and antiinflammation effect analysed. Result indicated variety with n-hexane extract of Beruwas Laut leaves have the antiinflammation effect at concentration 7,5%. Key Word : Antiinflammation, Scaevola taccada (Gaertn.) Roxb, Mice, n-Hexane.

UJI AKTIVITAS IMUNOGLOBULIN M (IgM) EKSTRAK ETANOL HERBA RUMPUT MUTIARA (Hedyotis corymbosa) PADA MENCIT (Mus musculus) JANTAN DENGAN METODE HEMAGLUTINASI Safriani Rahman; Bayu Putra; Rachmat Kosman; Riska Mustika
As-Syifaa Jurnal Farmasi Vol 4, No 2 (2012): AS-SYIFAA Jurnal Farmasi
Publisher : Fakultas Farmasi UMI

A Research About Activity of Ethanol of Pearl Grass (Hedyotis corymbosa) On The Imunoglobulin M (IgM) by Hemaglutination Method Had Been Conducted of Male Mice. This research purpose to established of activity imunoglobulin M (IgM) from ethanol extract of pearl grass (Hedyotis corymbosa). Mice is animal that used for this research,The mice was divided into 4 treatment groups, where each group consisted of 3 mice. The first group as negative control, and each group was given Sheel Red Blood Cell (SRBC) 2 % as many 0,1 ml intraperitonially, after that negative control group was administrated with air sulingt, and other group was administrated with ethanol extract dose 26 mg, 78 mg, dan 130 mg for five days. The blood from all group was collected by intracardial after five days. The activity of imunoglobulin M (IgM) was measured by hemaglutination method based on titer of the imunoglobulin M (IgM) there was highest dilution of mice blood serum in which aglutination was showed. Research result showed Ethanol extract of Pearl Grass (Hedyotis corymbosa) at 26 mg, 78 mg, and 130 mg dose, can increased imunoglobulin M (IgM) activity.Key words : Imunoglobulin M, Hedyotis corymbosa, Hemaglutination Method

AKTIVITAS ANTIMIKROBA EKSTRAK ETANOL BATANG WOLE WOE TERHADAP MIKROBA PATOGEN MENGGUNAKAN DIFUSI AGAR Fitriana Fitriana; Sitti Amirah; Safriani Rahman; Sukmawati Sukmawati
As-Syifaa Jurnal Farmasi Vol 15, No 1 (2023): AS-SYIFAA JURNAL FARMASI
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56711/jifa.v15i1.967

Infectious diseases can be caused by the entry of microorganisms such as bacteria, fungi, parasites, and viruses that can cause diseases in humans. One of the plants used empirically by the Weda community in Central Halmahera is the stem part of the wole woe plant. The aim of this study was to determine the antimicrobial activity of the ethanol extract of wole woe stems against pathogenic microbes such as Propionibacterium acnes, Escherichia coli, Salmonella thypi, Shigella dysentriae, Vibrio cholerae, and Candida albicans. This study used the agar diffusion method with various concentrations of 2.5%, 5%, and 10%, and positive controls for bacteria with chloramphenicol, positive controls for fungi with nystatin, and DMSO as a negative control. Based on the average diameter of the inhibition zone obtained, the test microbes were classified into the medium-strong category because they had an inhibition zone diameter ranging from 9 mm to 13 mm. The positive control for chloramphenicol for bacteria was classified into the very strong category because it had an inhibition zone diameter of >20 mm, while the positive control for nystatin for fungi was classified into the strong category because it had an inhibition zone diameter of >10 mm. Based on these tests, it can be concluded that the ethanol extract of wole woe stems has antimicrobial activity

Co-Authors Anak Agung Istri Sri Wiadnyani Bayu Putra Fitriana Fitriana Franita Achmad Mustari Mustari Rachmat Kosman Riska Mustika Riyan Wulansari Puspa Seruni Sitti Amirah

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