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ANALISIS KANDUNGAN POLIFENOL DALAM RUMPUT LAUT Sargassum sp DENGAN METODE SPEKTROFOTOMETRI UV-VISIBLE Pirman AP; Rachmat Kosman
As-Syifaa Jurnal Farmasi Vol 1, No 1 (2009): AS-SYIFAA Jurnal Farmasi
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/jifa.v1i1.90

Seaweed are one of resource foreign exchange of state and earning source for coastal area society. Besides can be used direct upon which food, some result processing of seaweed like gelatinous, carrageenan and alginate represent the compound which important enough in industry. A lot of research proving that seaweedis substance of food which important, like some among other thing is anticancer, antioxidant, preventing kardiovaskular, and as diet food. As for content of chemistry compound anticipated by a sharing to cause the effect is compound polyphenol. Referring to above the mentioned, and to know furthermore hit the content polyphenol in Sargassum sp seaweed, is hence done by analysis research polyphenol in Sargassum sp seaweed. This research benefit is to give the erudite evidence and information about existence of content polyphenol of Sargassum sp seaweed. This research is done by using method of spectrofotometric UV-Visibel and as reagent used by Folin Ciocalteu and Na2CO3 yield the blue colour, then read by absorbance at 670 nm. As standard condensation used by tannat acid with the concentration 0,25; 0,5; 1,0; 2,0; 4,0; and 8,0 ppm. From research result indicate that the Sargassum sp seaweed contain the polyphenol with the rate polyphenol of Sargassum sp I as much 0,077 mg/100 g and Sargassum sp II as much 0,071mg/100 g.Key Words : Polifenol, Sargassum sp, Spectrofotometric UV-Vis

AKTIVITAS ANTIMIKROBA EKSTRAK DIETIL ETER KARANG LUNAK Sinularia sp. TERHADAP BEBERAPA MIKROBA UJI SECARA KLT- BIOAUTOGRAFI Rachmat Kosman
As-Syifaa Jurnal Farmasi Vol 2, No 2 (2010): AS-SYIFAA Jurnal Farmasi
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/jifa.v2i2.112

An antimicrobial assay has been done to Sinularia sp. The preliminary research has done screening toward extract of ethanol, diethyl ether, and n-butanol concentration 1 mg/ml using 9 trial microbe. The result has been showed that diethyl ether extract actively to inhibiting growth of Pseudomonas aeruginosa, Salmonella thypi, and Streptococcus mutans. The antimicrobial activity assay toward diethyl ether extract of Sinilaria sp. is carried out by liquid dilution methode to find the Minimum Inhibitory Concentration (MIC) value by concentration 0,025%, 0,05%, 0,1%, 0,2%, 0,4%, and 0,8%. Experiment has been continued by into solidified medium to decide the Minimum Lethality Concentration (MLC). The result showed that MIC could not be determined due to turbidity of test solution, mean while the MLC toward Pseudomonas aeruginosa, Salmonella thypi, and Streptococcus mutans each of them 0,2%, 0,8%, and 0,8%. To identify the group of the compound in diethyl ether extract which gave antimicrobial activity by TLC-Bioautography test. Then obtained best result from separation of compound by TLC which using eluent combination n-Hexan : etil asetat (6 : 4). The result of TLC-Bioautography test showed that growth of Pseudomonas aeruginosa can inhibited by spot at the rate of flow (Rf) 0,9 , of Salmonella thypi can inhibited by spot at the rate of flow (Rf) 0,9 and 0,56 and then of Streptococcus mutans can inhibited by spot at the rate of flow (Rf) 0,24. Result of identifying of chemical compound indicated that the active compound give the positive for steroid at Rf 0,9, Rf 0,24 and Rf 0,56.Key Words : Antimikroba, Sinularia sp, KLT-Bioautografi

STUDI INTERAKSI OBAT PADA PENGOBATAN PASIEN DIABETES MELLITUS YANG DISERTAI TROMBOSIS DI RSUP. Dr. WAHIDIN SUDIROHUSODO MAKASSAR Rachmat Kosman
As-Syifaa Jurnal Farmasi Vol 3, No 2 (2011): AS-SYIFAA Jurnal Farmasi
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/jifa.v3i2.134

The aim of this study was to determine the interactions of drugs that used to treat the Diabetes Mellitus patiens espoused by Trombosis at RSUP. DR. Wahidin Sudirohusodo in Makassar. The research concerning by means non-experimental with descriptive approach was to collect the data with retrospectively compared take from medical data then to seach the drugs that interacting each other on Diabetes Mellitus patient espoused by Trombosis at RSUP. DR. Wahidin Sudirohusodo in Makassar. From determinable research result that in the year 2007 interaction among drug of Diabetes Mellitus ( Sulfonylurea) with the drug antitrombosis ( Aspirin) that is equal to 61,6% while in the year 2008 equal to 38,4%, with the interaction type that is interaction pharmacokinetics in the form of distribution interaction, and effect generated by that is effect Pharmacodynamik.Key Words : Interaction, Diabetes mellitus, Thrombosis

UJI AKTIVITAS ANTIRADIKAL BEBAS FRAKSI DIETIL ETER BERUWAS LAUT (Scaevola taccada (Gaertn.) Roxb.) MENGGUNAKAN DPPH A. Amaliah Dahlia; Rachmat Kosman; Halija Halija
As-Syifaa Jurnal Farmasi Vol 5, No 1 (2013): AS-SYIFAA Jurnal Farmasi
Publisher : Fakultas Farmasi UMI

Radical scavenging activity of diethyl ether fraction from sea lettuce tree (Scaevola taccada (Gaertn.) Roxb.) using DPPH.The of research aims is determine the radical scavenging activity of sea lettuce tree based on the binding of free radical DPPH. Was conducted the research on test radical scavenging activity of sea lettuce tree (Scaevola taccada (Gaertn.) Roxb.) and then compared with the radical scavenging activity Vitamin C. Five thousand grams of sea lettuce tree (Scaevola taccada (Gaertn.) Roxb.) extraced by maceration using ethanol. Dry ethanol extract was partitioned with solid-liquid partition, using diethyl ether and then tested for activity and was obtained radical scavenging IC50 value 27,06 µg/mL.Key Word : Radical Scavenging, Scaevola taccada, DPPH

UJI EFEK HIPOGLIKEMIK EKSTRAK KLOROFORM DAN n-BUTANOL DAUN BELIMBING WULUH (Averrhoa bilimbi L.) PADA MENCIT (Mus musculus) YANG DIINDUKSI ALOKSAN Rachmat Kosman
As-Syifaa Jurnal Farmasi Vol 4, No 1 (2012): AS-SYIFAA Jurnal Farmasi
Publisher : Fakultas Farmasi UMI

The research About, Hypoglycemic Effect Test Extracts Chloroform and n-Butanol Leaf Belimbing Wuluh (Averrhoa bilimbi L.) Against Mice (Mus musculus) The Induced by Aloksan. This absorvation is done withaim to determine the hypoglycemic of test chloroform and n-butanol leaf belimbing wuluh (Averrhoa bilimbi L.) against mice (Mus musculus) with the main aloksan. This animal abservatian try to inductied. With aloction with the aim to destroy sel-β pancreas and try to rise the animal blood glucose rate. This research utilized 18 male mice divided into 6 groups, each group consisted of 3 male mice. Groop I was given 0,182 gram/kgBB of chloroform extract, groop II was given 0,091 gram/kgBB chloroform extract, groop III was given 0,182 gram/kgBB n-butanol extract and groop IV was given 0,091 gram/kgBB n-butanol extract, and groop V was the positif comparison groop that given glybenclamide sespention and groop VI is the groop with negative control that was given Na CMC 1%. It was given by feeded with volume of 1 ml/ 30 gBB. The abservatian reault shaw that chloroform ekstrak and n-butanol belimbing wuluh leat (Averrhoa bilimbi L.) has the effect to deerease glucose blood to mice (Mus musculus).Key Words : Hipoglycemic, Avverhoa bilimbi, Aloxan

UJI AKTIVITAS ANTIBAKTERI EKSTRAK ETER DAUM MIMBA (Azadirachta indica A.Juss) SECARA KLT-BIOAUTOGRAFI TERHADAP BAKTERI Staphylococcus aureus Dan Pseudomonas aeruginosa Rachmat Kosman
As-Syifaa Jurnal Farmasi Vol 1, No 1 (2009): AS-SYIFAA Jurnal Farmasi
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/jifa.v1i1.89

Research of antimicrobial activity assay of mimba leaves (Azadirachta indica A.Juss) the pleminary research has been done by screening test several microbes such as Staphylococcus aureus, Staphylococcus epidermidis, Streptococcus mutans, Bacillus subtilis, Pseudmonas aeruginosa, Salmonella thyposa, Escherchia coli, Vibrio sp and Candida albicans, to the methanol, ether, and n-Butanol extract of mimba leaves (Azadirachta indica A.Juss) in consentration 1 mg/ml. The result showed that the ether extract inhibited bacterial growth actively of Staphylococcus aureus and Pseudomonas aeruginosa. Antimicrobe potency assessment on ether extract of mimba leaves (Azadirachta indica A.Juss) has done by liquid-liquid dilution methode to find out the MIC value in consentration 10 mg/ml; 5 mg/ml; 1 mg/ml; 0.5 mg/ml and 0.1 mg/ml respectively which continue on solidified medium ti find out the MLC to predict the compound group in other extract which antimicrobe activity it was done bioautography TLC. The best result has been obtained from separating compound by TLC methode which used mixed eluen n-Hexane : Ethyl Acetate (6:4). The result showed that MIC could not be determined due to the turbidity of test solution, whilw manimum MLC of ether extract of mimba leaves (Azadirachta indica A.Juss) 10 mg/ml toward Staphylococcus aureus nor Pseudomonas aeruginosa bacteria. Bioautography TLC test on Staphylococcus aureus and Pseudomonas aeruginosa showed that the compound group which predicted to impart the antimicrobe activity to the ether extract of mimba leaves (Azadirachta indica A.Juss) was alkaloid.Key words : Azadirachta indica, Bioautography TLC, antimicrobe

FERMENTASI UBI KAYU (Manihot utillisima Pohl) DENGAN RAGI Monascus purpureus UNTUK PRODUKSI ZAT WARNA ANGKAK Rachmat Kosman; Pirman AP; Aco Mappacanda
As-Syifaa Jurnal Farmasi Vol 2, No 1 (2010): AS-SYIFAA Jurnal Farmasi
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/jifa.v2i1.105

Has conducted research on the cassava (Manihot utillisima Pohl.) fermentation with Monascus purpureus yeast to angkak essence pigmen production. This research aimed to make angkak pigmen by solid and pigmen extraction from fermentasion using Monascus purpureus. Then the wevelength is measured by using spectrophotometry UV-Vis. The result of research is 30 gram of cassava (Manihot utillisima Pohl.) fermented product obtained angkak dye with yellow dye % levels as much as 36,64%. Where the results of measurements of spectrophotometry UV-Vis showed that the maximum wevelength of 398,0 nm.Key Words : Manihot utillisima Pohl, Monascus purpureus, Angkak

ANALISIS KADAR ALKOHOL PRODUK KOMBUCHA DAUN PERMOT (Passiflora foetida L.) ASAL MAKASSAR SULAWESI SELATAN SECARA KROMATOGRAFI GAS Herwin Herwin; Rachmat Kosman; Fitriani Fitriani
As-Syifaa Jurnal Farmasi Vol 5, No 2 (2013): AS-SYIFAA Jurnal Farmasi
Publisher : Fakultas Farmasi UMI

Preliminary research permot leaf (Passiflora foetida L.) used Acetobacter xylinum bacterial culture and Sacharomyces cerevisiae yeast fermentation in determined the alcohol content of kombucha with the purpose of determined the alcohol content of kombucha products permot leaf (Passiflora foetida L.) from Makassar in South Sulawesi gas chromatography. Based on result of research fermentation of kombucha product from permot leaf by add glucose 100 gram and inoculum kombucha 10 % obtaired content by gas chromatography as big as 0,0627292 %. Keyword : Permot leaf, kombucha, alcohol, gas chromatography

ANALISIS KANDUNGAN POLIFENOL DALAM RUMPUT LAUT Eucheuma sp DENGAN METODE SPEKTROFOTOMETRI UV-VISIBLE Rachmat Kosman; Pirman AP; Sukmawati Syarif
As-Syifaa Jurnal Farmasi Vol 1, No 2 (2009): AS-SYIFAA Jurnal Farmasi
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/jifa.v1i2.95

Seaweed are one of resource foreign exchange of state and earning source for coastal area society. Besides can be used direct upon which food, some result processing of seaweed like gelatinous, carrageenan and alginate represent the compound which important enough in industry. A lot of research proving that seaweed is substance of food which important, like some among other thing is anticancer, antioxidant, preventing cardiovascular, and as diet food. As for content of chemistry compound anticipated by a sharing to cause the effect is compound polyphenol. Referring to above the mentioned, and to know furthermore hit the content polyphenol in Eucheuma sp seaweed, is hence done by analysis research polyphenol in Eucheuma sp seaweed. This research benefit is to give the erudite evidence and information about existence of content polyphenol of Eucheuma sp seaweed. This research is done by using method of spectrofotometric UV-Visible and as reagent used by Folin Ciocalteu and Na2CO3 yield the blue colour, then read by absorbance at 670 nm. As standard condensation used by acid tannat with the concentration 0,25; 0,5; 1,0; 2,0; 4,0; and 8,0 ppm. From research result indicate that the Eucheuma sp seaweed contain the polyphenol with the rate polyphenol of Eucheuma sp I as much 0,054 mg/100g and Eucheuma sp II as much 0,053 mg/100g.Key Words : Polifenol, Euchema sp and Spectrofotometri UV-Vis.

PRODUKSI YOGHURT dan SOYGHURT DARI SUSU SKIM dan SUSU KEDELAI DENGAN VARIASI BAHAN PENSTABIL Rachmat Kosman
As-Syifaa Jurnal Farmasi Vol 3, No 1 (2011): AS-SYIFAA Jurnal Farmasi
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/jifa.v3i1.127

A research had been done of Yoghurt and soyghurt production from skim milk and soya milk with variation of stabilizer agent. Yoghurt is fermentation milk product made from fermentation milk uses acid lactic bacteria, soyghurt is fermentation milk product made from fermentation soya milk uses acid lactic bacteria. To get the best quality of yoghurt and soyghurt usually added stabilizer agent so that get the best consistency, viscosity and stability. The aim of this investigation is to determine influence of milk kinds and stabilizer agent at Yoghurt and soyghurt production from skim milk and soya milk. Yoghurt made by skim milk and soyghurt made by soya milk with three variation of stabilizer agent, which 0,9% gelatine, 0,9% CMC, and 0.9% caragenan. The assay were organoleptic observation, pH and viscosity measurement, % acid lactic content test, and total of acid lactic bacteria test. The assay is done after storage at 50C. Organoleptic observation is consistency, odor, and taste. pH measurement by pH’s universe paper than viscosity measurement by brookfield viscometer with three replication, 50 rpm rates. % lactat acid content test by alkalimetry method. And total of acid lactid bacteria test by pouring method. The investigaton result can be concluded that stabilizer agent influence consistency, viscosity and prevent of separation between solid and liquid phase at yoghurt and soyghurt. 0,9% gelatine is the best stabilizer agent at yoghurt and soyghurt prodution.Key Words :Yoghurt, Soyghurt, Skim, Stabilizer Agent

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