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All Journal As-syifaa Jurnal Farmasi
Harti Widiastuti
Fakultas Farmasi, Universitas Muslim Indonesia, Makassar
Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology

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PENGUJIAN AKTIVITAS EKSTRAK ETANOL KULIT BUAH KECOMBRANG (Etlingera elatior (Jack) R.M.Sm) SEBAGAI INHIBITOR TIROSINASE Harti Widiastuti; Zainal Abidin
As-Syifaa Jurnal Farmasi Vol 13, No 1 (2021): AS-SYIFAA JURNAL FARMASI
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/jifa.v13i1.769

Abstract

Healthy skin should have a flat surface, the texture is soft, elastic, and have the same skin color. Skin color is determined by the size, number and distribution of melanin pigment. Pigment brownish pigment melanin is to protect the skin from UV light scattering. An enzyme that plays a role in this browning reaction is tyrosinase. Based on this research is conducted on the fruit skin kecombrang to see the activity of the enzyme tyrosinase barriers and whether rind kecombrang can inhibit tyrosinase enzyme and with the aim to utilize natural materials and waste that can inhibit the enzyme tyrosinase and can be used as a skin whitheter. Research iniated by the extraction of fruit skins kecombrang using etanol. Flavonid content test on the sample using Mg powder and HCl p, the results show a color change from dark brown to yellow. So positive it contains flavonoids. Measurements were contucted on a maximum wavelength of 478,003 nm, using the substrate L-tyrosine and the enzyme tyrosinase. Using comparators hidroquinon. Of the results of this study concluded that kecombrang fruit peel ectract at a concentration of 2 mg/mL could inhibit amounted to 55,92% and a concentration of 2,5 mg/mL could inhibit amounted to 56,58%
ANALISIS KADAR KUERSETIN PADA EKSTRAK ETANOL DAUN MIANA (Plectranthus scutellarioides (L.) R.Br.) SECARA HPLC (High Performance Liquid Chromatography) Sukmawati Sukmawati; Harti Widiastuti; Miftahuljanna Miftahuljanna
As-Syifaa Jurnal Farmasi Vol 11, No 1 (2019): AS-SYIFAA Jurnal Farmasi
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (515.556 KB) | DOI: 10.33096/jifa.v11i1.462

Abstract

One of the medicinal plants that people often use as a medicine is the Miana leaves (Plectranthus scutellarioides (L.) R.Br.). The Miana leaves are empirically used to treat coughs, heart disease, worm medicines, antimicrobials, antioxidants, antiseptics, bronchitis, hemorrhoids, tuberculosis, and other pharmacological activities. The miana leaves contain secondary metabolite compounds of flavonoids, steroids, tannins, and saponins. One of the most critical flavonoids is quercetin. This study aimed to determine the quercetin content of ethanol extract of miana leaves by HPLC (High Performance Liquid Cromatography). The extraction method by maceration using 96% ethanol. Determination of quercetin content in miana leaf ethanol extract by HPLC with C18 column, maximum wavelength of 369.11 nm with mobile phase methanol : aquabides (59:41) flow rate of 1 mL/minute. The results showed retention time for quercetin as a comparison of 4,183 minutes, a sample of 4.563 minutes, and an additional sample of 4,363 minutes. The average content of quercetin in miana leaf ethanol extract was 3.122 mg/g or 0,312%.
Co-Authors Miftahuljanna Miftahuljanna Sukmawati Syarif, Sukmawati Zainal Abidin