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Ardi Fauzi
Mahasiswa program pendidikan S-1 kedokteran umum FK Undip.
Dentistry Health Professions Medicine & Pharmacology Nursing Public Health

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Efek Protektif Methylprednisolone pada Testis Kontralateral Tikus Wistar yang dilakukan Torsio-Detorsio: Ditinjau dari variabel pemeriksaan Histopatologi Johnsen score, jumlah lapis sel tubulus seminiferus, jumlah sel nekrosis, dan derajat adhesi neutrofil Wibisono, Dimas Sindhu; Nugroho, Leonardo Cahyo; Muhammad, Krisna; Fauzi, Ardi; Putra, Adityas Mahendra; Hidayat, Afif Iman
Medica Hospitalia : Journal of Clinical Medicine Vol. 8 No. 1 (2021): Med Hosp
Publisher : RSUP Dr. Kariadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (569.019 KB) | DOI: 10.36408/mhjcm.v8i1.493

Abstract

Background: Testicular torsion is an emergency situation and requires immediate surgery. Testicular torsion accounts for 13-54% of cases of acute pediatric scrotal disease and occurs in 1 in 4,000 men aged <25 years and 1 in 160 men over 25 years. Even though the intervention was carried out for less than 6 hours, post-detortion testicular tissue mortality was still high, due to reperfusion ischemic injury due to excessive production of ROS (Reactive Oxygen Species). The contralateral testis is often affected after torsion-detortion due to the effects of ROS. The provision of additional therapy after detortion is an urgent need to be found because it can reduce the death of testicular tissue due to reperfusion ischemic injury. Methods: It is an experimental study with a randomized controlled study design with post test only control group design. The research sample was 18 Wistar rats divided into 3 groups. Torsion of the ipsilateral testis is performed, then detortion and intravenous therapy are administered. The apoptotic index (infertility) was observed on the Johnsen score variable, the number of seminiferous tubular cell layers, neutrophil adhesion and the number of necrotic cells in the Eosin Hematoxyline in the contralateral testis. Furthermore, statistical analysis is carried out, the results are presented in tables and figures. Results: There was a significant difference between the Methylprednisolone group and the Torsion Detortion group with p = 0.008 in the Johnsen score variable and the number of seminiferous tubular cell layers. Discussion: Methylprednisolone as an anti-inflammatory has been proven in its function to reduce ROS so that it can reduce reperfusion ischemic injuries.
Factors Affecting Gastric Perforation Patient Outcome with History of Arthritis and Long Term Use of NSAIDs in Dr. Kariadi Semarang Period 2020 – 2022 Nugroho, Leonardo Cahyo; Fauzi, Ardi; Priambodo, Agus
Medica Hospitalia : Journal of Clinical Medicine Vol. 10 No. 3 (2023): Med Hosp
Publisher : RSUP Dr. Kariadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36408/mhjcm.v10i3.978

Abstract

Background: The incidence of gastric perforation gives a high mortality outcome. The second most common cause of gastric perforation is long-term use of NSAIDs. In cases of arthritis during the COVID-19 pandemic, a conservative therapeutic approach and administration of NSAIDs are preferred. Due to this, researchers want to know the factors affecting gastric perforation cause by NSAIDs. Method: An analytic descriptive study with a retrospective cohort study design, using electronic medical records of patients at RSUP Dr. Kariadi Semarang from January 2020 - December 2022. Data collected was in the form of demographics, diagnoses, procedures, preoperative conditions, scoring system, and outcome. Results: PULP score, one of prognostic factor, has a good level of significance compared to other scoring systems in determining the prognostic mortality of patients with gastric perforation. The combination of variables between the type of NSAIDs and the type of arthritis has a direct correlation with a positive inter-variable power of 86.7% and a significance of 0.049 on patient outcome. Conclusion: NSAIDs pose a risk of gastric perforation in long-term use. tNSAIDs carry a higher risk inducing gastric perforation than selective NSAIDs.
Co-Authors Agus Priambodo Dimas Sindhu Wibisono Hidayat, Afif Iman Krisna Muhammad, Krisna Leonardo Cahyo Nugroho Putra, Adityas Mahendra