Article Per Year (5 Year)
p-Index From 2020 - 2025
0.751
P-Index
This Author published in this journals
All Journal Journal of Innovation and Applied Technology Indonesian Green Technology Journal The Journal of Pure and Applied Chemistry Research INDONESIAN JOURNAL OF ESSENTIAL OIL Jurnal Penelitian Pendidikan IPA (JPPIPA)
Elvina Dhiaul Iftitah
Brawijaya University
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Earth & Planetary Sciences Education Engineering Materials Science & Nanotechnology Medicine & Pharmacology Physics Other

Published : 6 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 1 Documents
Search
Journal : Jurnal Penelitian Pendidikan IPA (JPPIPA)

 1 
Skrining Aktivitas Senyawa Limonen dan Turunannya dalam Menghambat Enzim MMP-2, MMP-9, Cyclin A2 pada Kanker Payudara Triple Negative melalui Molecular Docking Qurrotul A'yun; Warsito Warsito; Elvina Dhiaul Iftitah
Jurnal Penelitian Pendidikan IPA Vol. 8 No. 6 (2022): December
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v8i6.1917

Abstract

Breast cancer is among the diseases with the highest mortality rate in women in the world. The triple negative cancer subtype with aggressiveness and metastatic ability causes the sufferer to be difficult to treat. Targeted treatment efforts of natural ingredients such as limonene and its derivatives are more profitable due to their easy excretion process. Screening the activity of compounds through docking specifically provides convenience in the synthesis process in the laboratory. Limonene compounds and their derivatives will be interpreted against the enzymes MMP-2 (PDB ID: 3AYU), MMP-9 (PDB ID: 4H1Q) and Cyclin A2 (PDB ID: 2V22) involved in the cellular function of triple-negative breast cancer using PyRx 9.0 software. The docking results showed that the limonelyl salicylate compound provided the best binding affinity value against the enzymes MMP-2, MMP-9, and Cyclin A2 with successive values of -7.7, -8.8, and -6.7 kcal/mol.
Co-Authors Adilatunnisa Nur Indah Berliana Edi Priyo Utomo Fadhlih Arya Seta Fitri Ariadna Sodi Miranda Khoirun Nisyak Masruroh Masruroh Mohammad Farid Rahman Qurrotul A'yun Rizki Wahyu Aji Wibowo Siti Mariyah Ulfa Udrika Lailatul Qodri Warsito Warsito Yasmin Zafirah