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All Journal Journal of Natural Science and Integration Molekul: Jurnal Ilmiah Kimia
Syadza Firdausiah
Chemistry Departement, Faculty of Mathematics and Natural Sciences, Hasanuddin University, Makassar, 90245
Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Education Materials Science & Nanotechnology

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The Potential of Paku Gajah (Angiopteris evecta) as Antitumor Through In Vitro and In Silico Studies Rasyid, Herlina; Asmirah, Asmirah; Firdausiah, Syadza; Arief, Ihsanul; Soekamto, Nunuk Hariani
Molekul Vol 19 No 2 (2024)
Publisher : Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.jm.2024.19.2.10644

Abstract

ABSTRACT. Paku gajah (Angiopteris evecta) is one of the largest ferns which has been used empirically by the Dayak tribe of Kalimantan, Indonesia as a traditional medicine to treat various diseases, one of which is tumors. This research aims to determine the potential utilization of A. evecta stem extract as an antitumor by secondary metabolites analysis, toxicity and antitumor assay. The methods used in this study were gradual maceration using three solvents (n-hexane, ethyl acetate, and methanol), phytochemical screening, toxicity test, antitumor activity assay with the Alamarblue method, Liquid Chromatography-Mass Spectrometry (LC-MS) analysis, and molecular docking analysis. This study indicated that A. evecta stem extract contained secondary metabolites such as flavonoids, saponins, tannins, and steroids. The ethyl acetate and methanol were found as toxic extracts with LC50 130.67 and 314.31 µg/mL, respectively. In line with the toxicity, the antitumor activity of the ethyl acetate extract was the highest with an IC50 of 240.94 µg/mL and phytochemical analysis revealed the presence of violanthin and angiopteroside in the extract. Molecular docking showed that the binding energy and inhibition constants of violanthin and angiopteroside against receptors were higher than standard ligand F82. The interaction between violanthin and the receptor results five hydrogen-bond (H-bond) with Lys920, Cys919, Asp1046, and Leu840, while the angiopteroside produces four H-bonds with Leu836, Leu834, and Arg831. Keywords: Antitumor, molecular docking, paku gajah (Angiopteris evecta).
Readiness Model of Pre-Service Science Teachers for Integrating Education for Sustainable Development (ESD) Based on Green Science: A Structural Equation Modeling Analysis Iskandar, Suhendra; Firdausiah, Syadza
Journal of Natural Science and Integration Vol 9, No 1 (2026): Journal of Natural Science and Integration
Publisher : Universitas Islam Negeri Sultan Syarif Kasim Riau

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24014/jnsi.v9i1.39148

Abstract

The presence of Education for Sustainable Development (ESD) is crucial. Therefore, a comprehensive modeling approach is needed, particularly for pre-service teachers as future educators, a group that remains largely underexplored. This study aims to examine a structural model of the formation of the Intention to Integrate ESD among 199 pre-service science teachers at IAIN Sultan Amai Gorontalo. In this readiness model for ESD integration, sustainability literacy is positioned as the primary factor. At the same time, social norms and support, along with institutional support, are treated as contextual factors operating through psychosocial pathways. This study employed a quantitative approach, cross-sectional survey design to examine the structural relationships among variables. Data were analyzed using Structural Equation Modeling–Partial Least Squares (SEM-PLS) with SmartPLS 4 software. The results indicate that the proposed model explains a substantial proportion of variance in the intention to integrate ESD (R² = 0.744) and demonstrates adequate predictive relevance (Q² = 0.502). Institutional support emerges as the strongest predictor (β = 0.670, p = 0.000), while sustainability literacy shows a weaker yet significant effect (β = 0.279, p = 0.000). All constructs meet the required reliability and validity criteria. The findings reveal that, contrary to many theoretical assumptions emphasizing psychosocial mediation pathways, readiness to integrate ESD is predominantly influenced by institutional support rather than by sustainability literacy. In contrast, norms and social support exert their effects through indirect pathways, strengthened by sustainability literacy. This pattern further suggests the need for reformative institutional strategies in delivering ESD to students. Keywords: Education for sustainable development, psychosocial, sustainability literacy, SEM-PLS, SmartPLS 4
Co-Authors . Asmirah Ihsanul Arief Iskandar, Suhendra Nunuk Hariani Soekamto Rasyid, Herlina