Article Per Year (5 Year)
p-Index From 2021 - 2026
0.23
P-Index
This Author published in this journals
All Journal JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA JKKI : Jurnal Kedokteran dan Kesehatan Indonesia
Wahyu Widyaningsih
Faculty of Pharmacy, Ahmad Dahlan University, Yogyakarta, Indonesia
Chemistry Education Health Professions Medicine & Pharmacology Public Health Other

Published : 2 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 2 Documents
Search

 1 
Effects of ethanolic extract of arrowroot tubers (maranta arundinacea l.) on the level of MDA, SGPT and SGOT in ethanol induced rats Muhammad Reza Ramadhani; Mochammad Saiful Bachri; Wahyu Widyaningsih
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 8, No 1, (2017)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol8.Iss1.art3

Abstract

Background : The exposure of free radicals can induce oxidative stress. In the liver, this process will cause impaired liver function. Oxidative stress can be inhibited by antioxidants. Arrowroot tubers (Maranta arundinacea) contains phenolic, flavonoid, alkaloids and saponin compound that are potential as antioxidants. Objective : Determine the effect of ethanolic extract of arrowroot tubers (Maranta arundinacea) against oxidative stress using the parameter of MDA, SGPT and SGOT level in ethanol-induced rats. Methods : Animal models were divided into 5 groups, in which each group contained 6 rats. Group I (normal) and group II (control) was induced with CMC Na 0,5%. Group III, IV and V were given ethanolic extract of arrowroot tubers in the dosage of 125, 250 and 500 mg/Kg/day respectively. The extract was administered orally for 14 days. Induction of ethanol 5 gram/ KgBW was administered orally 1 hour after the last administration on day 14th except for group I. On day 15th, the animal blood was drawn to measure the levels of SGPT and SGOT, then the animals were sacrificed and their organs were analyzed to measure the levels of MDA in the liver. Data obtained in the form of MDA, SGPT and SGOT levels were statistically analyzed using ANOVA. Results : There is statistically significant difference between the utilization of ethanolic extract of arrowroot tubers (Maranta arundinacea) group with the control group in reducing the concentration of MDA (p<0,05), SGPT, and SGOT (p<0,05). Conclusions : The ethanolic extract of arrowroot tubers (Maranta arundinacea) is able to reduce the concentration of MDA, SGPT and SGOT in ethanol-induced rats.
Jatropha curcas L. Leaf Extract Effects on Blood Pressure and Lipid Levels in Hypertensive Rats with High-Fat Diet Moch. Saiful Bachri; Wiki Yuli Anita; Putri Dwi Lestari; Desi Eko Wulansari; Dwi Retno Nengtyas; Muhammad Ma'ruf; Sapto Yuliani; Wahyu Widyaningsih; Laela Hayu Nurani; Daru Estiningsih; Vivi Sofia
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 11 No. 1 (2024): JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jfiki.v11i12024.61-70

Abstract

Background: One of the main risk factors for cardiovascular diseases such as coronary atherosclerotic heart disease (CAHD) is dyslipidaemia or high levels of low-density lipoprotein (LDL) and triglycerides (TG) and low levels of high-density lipoprotein (HDL). Hypertension is also a cause of cardiovascular disease. One potential plant to lower LDL levels and blood pressure is Jatropha curcas, which is known to contain saponins, polyphenols, and flavonoids. Objective: The purpose of this study was to determine the effect of the ethanol extract of Jatropha curcas leaves (EEJCL) on blood pressure, LDL levels, and HDL levels in hypertensive rats given a high-fat diet. Methods: This study is an experimental study with a pretest-posttest control group design on male Wistar strain rats. Rats were divided into seven groups, namely the normal group, control group (induced with NaCl and given a high-fat diet), Captopril group, Simvastatin group, and EEJCL groups given doses of 1.8, 2.7, and 4.05 g/kg BW. The data obtained were analysed using the One-Sample Kolmogorov-Smirnov Test, Homogeneity of Variance, One-Way ANOVA, and Tukey Test. Results: The results showed that the administration of EEJCL could significantly lower LDL levels and blood pressure and increase HDL levels (p < 0.05) at doses of 1.8, 2.7, and 4.05 g/kg BW, and the dose of 4.05 g/KgBW was the most optimal dose. Conclusion: EEJCL has a potential for development in the treatment of hypertension and dyslipidaemia.
Co-Authors Daru Estiningsih Desi Eko Wulansari Dwi Retno Nengtyas Laela Hayu Nurani Moch. Saiful Bachri Moch. Saiful Bachri Muhammad Ma'ruf Muhammad Reza Ramadhani Putri Dwi Lestari Sapto Yuliani Vivi Sofia Wiki Yuli Anita