Garuda - Garba Rujukan Digital

Article Per Year (5 Year)

p-Index From 2020 - 2025

P-Index

This Author published in this journals

All Journal Pharmaciana: Jurnal Kefarmasian

Moch. Saiful Bachri

Faculty Of Pharmacy, Ahmad Dahlan University, Yogyakarta, Indonesia

Author-ID : 2385441

Medicine & Pharmacology

Published : 4 Documents Claim Missing Document

Claim Missing Document

Articles

EFEK TOKSISITAS FRAKSI ETIL ASETAT AKAR SENGGANI (Melastoma affine D.Don ) PADA ORGAN HEPAR, GINJAL DAN TESTIS Moch Saiful Bachri
Pharmaciana Vol 1, No 1 (2011): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Melastoma affine (MA) is a medicinal plant commonly found in south East Asia and China. The aim of the study is to investigate the toxicity effect of MA toward vital organs. Thirty two Wistar adult male rats were divided into five groups consisting of six animals each the rats in group except control group, eight animals. The rats in group I (control) were administered 0.5% CMC Na orally, while CMC Na suspension of ethyl acetate fraction of MA root (62.5, 125, 250,and 500 mg/kg body weight) were given to the II, III, IV and V groups, respectively. The CMC Na suspensions of ethyl acetate fraction of MA root were administered for 22 days. Rats were sacrificed at the 23th day. Liver, kidney, testis were collected for histopathological observation. The observation result on liver and kidney showed no difference compare to control groups, meanwhile on testis, the administration of ethyl acetate fraction of MA root at dose (250, 500 mg/kg body weight) caused necrosis on seminiferus tubules and decreasing sperm counting. The conclusion, administration of ethyl acetate fraction of MA root caused toxicity effect on testis with necrosis on seminiferus tubules.

Potensi ekstrak etanol 70% akar saluang balum (Lavanga sarmentosa blume kurz) terhadap kualitas dan viabilitas sperma mencit Yaumi Musfirah Syarif; Moch Saiful Bachri; Laela Hayu Nurani
Pharmaciana Vol 6, No 2 (2016): Pharmaciana
Publisher : Universitas Ahmad Dahlan

The present study tried to investigate potency of L. sarmentosa root extract on quality and viability of mice sperm.This study used 25 Swiss male mice were randomly divided into five experimental groups of 5. The ethanolic extract of L. Sarmentosa (100, 200, 400 mg/kg b.w/days), control and X-gra were administered orally for 14 days. The animals were evaluated for sperma quality (sperm count and sperm motility) and viability at 14 days treatment. The results showed that administration of L.sarmentosa roots extract significantly increasing the sperm count (970x106cell/mL) at 400 mg/kg b.w/days (P 0.0040). The extract dose of 200 mg/Kg b.w and 400 mg/Kg b.w had the highest motility values (95%). Viability of sperm are 83.8%; 96.0%; 87.8% respectively at a dose of 100 mg/kg b.w, 200 mg/kg b.w and 400 mg/kg b.w. Present finding oral administration ofÂ L. sarmentosa roots extract has a potency of the quality and viability of mice sperm.

PENGARUH PEMBERIAN EKSTRAK ETANOL DAN KLOROFORM DAUN SIRSAK TERHADAP KOLESTEROL TOTAL DAN TRIGLISERIDA PADA TIKUS YANG DIINDUKSI ALOKSAN Deni Firmansyah; Moch Saiful Bachri; Nurkhasanah Nurkhasanah
Pharmaciana Vol 6, No 1 (2016): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Annona muricata plant is a medicinal plant using by research and drug for human healthy including diabetes mellitus. This research aimed to determine the effect of ethanol extract and chloroform extract of the sirsak leaf as antidiabetes mellitus. This research was conducted in 9 groups of male Wistar rats consisting of 5 rats per group, consisting of normal control, alloxan control, glibenclamide control dose of 10 mg/Kg BW, group of ethanol extract sirsak leaf dose of 50 mg/Kg BW; 100 mg/Kg BW; 200 mg/Kg BW, and group of chloroform extract sirsak leaf dose of 50 mg/kg BW; 100 mg/Kg BW; 250 mg/Kg BW. Tests carried out for 2 weeks. It also conducted assays of total flavonoids and histopathological tests of pancreatic Î² cells. Results of this research showed that the ethanol extract ofÂ sirsak leaves dose of 200 mg/Kg BW has activity in decreasing blood glucose levels better than any other group. Results of the ethanol extract and chloroform extract all doses except the ethanol extract treatment group dose of 200 mg/kg BW and 100 mg/kg BW after a 14-day look is still high triglyceride levels and decrease in total cholesterol (TC) were seen in all group Ethanol extract dose of 200 mg / kgBWÂ has a good potential to reduce levels of triglycerides and total cholesterol. The conclusion of this research is the ethanol extract of sirsak leaf have activity antidiabetic mellitusand decreased total cholesterol.Â

EFEK HEPATOPROTEKTIF EKSTRAK METANOL JAHE MERAH (Zingiber officinale Roscoe) PADA MENCIT JANTAN YANG DIINDUKSI CCl4 Moch Saiful Bachri
Pharmaciana Vol 1, No 2 (2011): Pharmaciana
Publisher : Universitas Ahmad Dahlan

MeOH extract of Zingiber officinale Roscoe (ZO) were investigated for hepatoprotective effect at the doses (p.o) of 100 and 200 mg/kg body weight using CCl4 induction method. Male Swiss mouse (25±1,5 g) were treated with ZO doses 100 and 200 mg/kg bw and Sillymarin (100 mg/kg bw) for two week before treatment with a single dose of CCl4, 0.5 ml/kg bw, intraperitoneally. The mouse were sacrifactivity of SGPT-SGOT. The study showed the activity of SGPT of MeOH extract of ZO doses 100 mg/kg bw and 200 mg/kg bw, Sillymarin, control and normal groups are (34.51±5.34), (27.38±4.28), (27.26±1.06), (36.61±1.87), and (25.37±2.01) U/L, respectively. While the activity of SGOT of MeOH extract of ZO doses 100 mg/kg bw and 200 mg/kg bw, Sillymarin, control and normal groups are (88.88±0.94), (83.88±3.91), (83.99±7.24), (92.97±8.16), and (82.99±3.97) U/L, respectively. MeOH extract of ZO dose 200 mg/kg BW and Sillymarin significantly (p < 0,05) decrease the activities two enzymes (SGPT and SGOT). The results showed MeOH extract Zingiber officinale Roxb has hepatoprotective effect

Co-Authors Deni Firmansyah Laela Hayu Nurani Muhammad Reza Ramadhani Nurkhasanah Nurkhasanah Wahyu Widyaningsih Yaumi Musfirah Syarif

Title

Found 4 Documents
Search

Abstract

Abstract

Abstract

Abstract

Title Search

Found 4 Documents Search

Abstract

Abstract

Abstract

Abstract

Title

Found 4 Documents
Search