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All Journal Pharmaciana: Jurnal Kefarmasian JKKI : Jurnal Kedokteran dan Kesehatan Indonesia Journal of Pharmaceutical and Sciences.
Any Guntarti
Faculty of Pharmacy, Universitas Ahmad Dahlan
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health

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Effect of regional variation on the total flavonoid level of ethanol extract of mangosteen (Garcinia mangostana) peels Any Guntarti; Juniati Annisa; Mulki Mughniy; Fitria Rizqi
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 8, No 2, (2017)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol8.Iss2.art9

Abstract

Background : Currently, traditional medicines have been widely used by the public. One of them is mangosteen peel. Extract of mangosteen peel contains alkaloids, glycosides, steroids, flavonoids, polyphenols, and tannins. In order to ensure the quality of the extract so that its chemical content can be guaranteed, it is necessary to standardize the quality of the extract that consists of specific parameters. Objective : This study aims to determine the specific parameters using Thin-Layer Chromatography (TLC) and total flavonoid level of the ethanol extract of mangosteen peel from Kalimantan, Java, and Sumatra. Methods : This research was an explorative study. Extraction technique used was maceration with 70% ethanol solvent. The tested specific parameters, namely the identity of the extract with TLC and total flavonoid level, were determined afterward using visible spectrophotometry with the AlCl3 reagent. Results: The result of the qualitative test with TLC showed that the extract of mangosteen peel contains flavonoids, terpenoids, and anthraquinones. Total flavonoid level of ethanol extract of mangonsteen peel from Kalimantan, Java, and Sumatra were (0.301 ± 0.009); (0.398 ± 0.015); (0,747 ± 0,010) mg QE/g extract, respectively. Conclusion : Extract of mangosteen peel contains flavonoids, terpenoids, and anthraquinones. Total flavonoid level of ethanol extract of mangonsteen peel from Kalimantan, Java, and Sumatra were (0.301 ± 0.009); (0.398 ± 0.015); (0,747 ± 0,010) mg QE/g of extract, respectively.
Analysis of soft gelatin capsule with real-time polymerase chain reaction for halal autenthication Nina Salamah; Any Guntarti; Laela Hayu Nurani
Pharmaciana Vol 13, No 1 (2023): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (454.471 KB) | DOI: 10.12928/pharmaciana.v13i1.25694

Abstract

Halal medicine is an interesting topic to always discuss because it is a priority choice for Muslim consumers, one of which is halal capsules. Currently, molecular biology techniques such as real-time polymerase chain reactions are rapidly developing, including for the analysis of non-halal components based on DNA sequences. This study aimed to validate the quantitative PCR method for identifying DNA in gelatin-based products and to apply the confirmation method designed for capsule samples on the market circulating in Yogyakarta to prove the halalness of these samples. Validation of the porcine DNA detection analysis method on standard extraction of porcine gelatin using primer pairs obtained in previous studies. Validated methods are used for testing market capsule shells. The qPCR method using D-loop primers is specifically capable of amplifying porcine gelatin DNA up to a concentration of 0.5 pg/µL, with a CV value in the amplification response of porcine gelatin DNA isolates (1000 pg/µL) of 0.85% which meets the test criteria using the PCR. Three samples of commercial soft capsules tested gave a positive amplification response, meaning that the samples tested contained porcine DNA, and one negative sample, which probably had non-porcine gelatin. The application of this method is also very useful for ensuring the authenticity of the capsule shell, especially from cross-contamination and counterfeiting. 
Inhibitory activity of Carica pubescens leaf extract on cyclooxygenase: anti-inflammatory prospects of natural substances Sapto Yuliani; Anggoro Wicaksono; Citra Ariani Edityaningrum; Nuri Ari Efiana; Any Guntarti; Sugiyanto; Mustofa Ahda
Pharmaciana Vol. 16 No. 2 (2026): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/pharmaciana.v16i2.31419

Abstract

Inflammation represents a multifaceted biological reaction that plays a significant role in a variety of chronic pathological conditions and the search for natural anti-inflammatory agents remains a significant focus of pharmacological research. The objective of this study was to assess the in vitro anti-inflammatory properties of an ethanolic extract from the leaf of Carica pubescens (C. pubescens) by examining its effects on cyclooxygenase (COX) enzyme inhibition and conducting protein denaturation assays. An ethanolic extract of the leaf was prepared through maceration using 96% ethanol. Phytochemical screening conducted qualitatively demonstrated that the extract contained flavonoids, alkaloids, saponins, and tannins. Thin Layer Chromatography (TLC) analysis was performed to further identify flavonoids, with quercetin used as the reference standard. The anti-inflammatory activity was assessed using an enzyme immunoassay (EIA) for assessing inhibitory effects on COX-1 and COX-2 and a bovine serum albumin (BSA) denaturation assay. The chromatographic profile of the 96% ethanolic Carica pubescens leaf extract (CPLE 96%) showed a distinct spot with an Rf value comparable to that of quercetin under visible and ultraviolet observation, indicating the presence of quercetin-like flavonoid constituents. The CPLE 96% demonstrated potent, dose-dependent inhibition in both assays. In the protein denaturation assay, the CPLE 96% (100 µg/mL) showed 78.5 ± 2.9 % inhibition, significantly higher than ibuprofen (71.8 ± 2.0 %) and slightly lower than meloxicam (88.4 ± 0.9 %). In the COX inhibition assay, the CPLE 96% exhibited non-selective inhibition with half-maximal inhibitory concentration (IC50) values of 50.42 ± 0.54 µg/mL for COX-1 and 51.18 ± 0.61 µg/mL for COX-2 (Selectivity Index = 0.985 ± 0.017). The findings provide substantial scientific validation for the ethnomedicinal use of C. pubescens, highlighting its dual-acting anti-inflammatory mechanism by inhibiting key inflammatory enzymes and preventing protein denaturation. The extract shows significant potential as a source for developing natural anti-inflammatory therapeutics, warranting further investigation to isolate the active constituents and conduct in vivo studies.
Uji Kualitas dan Identifikasi Sabun Padat Komersial Berbasis Lemak Hewan Menggunakan FTIR Ni Komang Virginia Pradini; Nina Salamah; Any Guntarti; Nurkhasanah Nurkhasanah
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 1 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i1.1077

Abstract

Background: Solid soap is produced by saponification of fatty acids with strong bases, and its quality is influenced by the type of fat used. Objective: This study aims to evaluate the physical and chemical quality of solid soap made from beef tallow and lard and to identify compound profiles using Fourier Transform Infrared Spectroscopy (FTIR). Method: The methods include dry-rendering fat extraction, solid soap formulation, and soap quality tests (organoleptic properties, pH, moisture content, and foam height). FTIR analysis was conducted to compare the absorption spectra of each soap. Results: The results showed that soaps derived from both fat sources met all quality requirements specified in the Indonesian National Standard (SNI). FTIR analysis revealed generally similar spectral patterns; the lard solid soap exhibited a characteristic absorption band at approximately 3009 cm⁻¹, corresponding to =C-H stretching vibrations of unsaturated fatty acids. In contrast, this band was not detected in the solid soap made from beef tallow. In addition, the CH₂ rocking vibration around 720 cm⁻¹ was more pronounced in the beef tallow solid soap, indicating a higher proportion of long-chain saturated fatty acids. Conclusion: FTIR effectively identifies fat types and can be used in raw material authentication, especially in product halalness.
Co-Authors Anggoro Wicaksono Citra Ariani Edityaningrum Fitria Rizqi Juniati Annisa Laela Hayu Nurani Mulki Mughniy Mustofa Ahda Ni Komang Virginia Pradini Nina Salamah Nuri Ari Efiana Nurkhasanah Nurkhasanah Sapto Yuliani Sugiyanto