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Whika Febria Dewatisari, Whika Febria
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Earth & Planetary Sciences Education Environmental Science Immunology & microbiology Industrial & Manufacturing Engineering Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Public Health Other

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Potensi Antibakteri Minuman Fungsional Tradisional Jawa (Wedang Uwuh) Berdasarkan Variasi Waktu Rebusan Dewatisari, Whika Febria; Hariyadi, Hariyadi
Jurnal Teknologi dan Industri Pangan Vol. 35 No. 1 (2024): Jurnal Teknologi dan Industri Pangan
Publisher : Perhimpunan Ahli Teknologi Pangan Indonesia bekerjasama dengan Departemen Ilmu dan Teknologi Pangan, IPB University Bogor, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.6066/jtip.2024.35.1.10

Abstract

Wedang uwuh is a functional beverage prepared by boiling a combination of spices, namely sappan wood, ginger, nutmeg leaves, cinnamon leaves, cloves, and clove leaves. It is reported to have antioxidant, antibacterial, and immune-enhancing properties due to its active compounds. This traditional beverage shows potential in reducing infections caused by Escherichia coli, highlighting the importance of proper preparation methods. The objective of this study was to evaluate the antibacterial activity of wedang uwuh prepared by different boiling duration (5, 10, 15, and 20 min) to determine the optimal time for maximum effectiveness. Phytochemical changes, as indicated by color alterations, were assessed by a descriptive approach while a disc diffusion method was used as an antibacterial assay to measure the inhibition zone diameter against E. coli. Compounds in each treatment were analyzed using GC-MS. Phytochemical screening confirmed the presence of alkaloids, flavonoids, saponins, triterpenoids, and tannins in all variations. Antibacterial testing revealed that boiling for 15 min exhibited the highest activity, with an inhibition zone diameter of 10.43±1.33 mm, reflecting strong antibacterial efficacy. This result significantly differed from the 5 and 10 min treatments. The 5 min boiling treatment demonstrated a smaller inhibition zone with an average diameter of 5.71±1.67 mm, indicating moderate antibacterial activity, but it did not differ significantly from the 10 min treatment. A chemical analysis by GC-MS for the 15 min boiling sample successfully identified 23 compounds, and among these chemicals, hexadecanoic acid was found as the predominant component.
Phytochemical Constituent, Antibacterial and Antioxidant Leaves of Dracaena trifasciata (Prain) Mabb. Dewatisari, Whika Febria; To'bungan, Nelsiani
Jurnal Biodjati Vol 9 No 2 (2024): November
Publisher : UIN Sunan Gunung Djati Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15575/biodjati.v9i2.33528

Abstract

Sansevieria, commonly known as Dracaena trifasciata. Apart from serving as an ornamental and air-purifying plant, it also exhibits medicinal properties, making it a potential candidate for the development of novel natural drugs. The demand for natural antibacterial agents has significantly increased due to the rising incidence of resistance among pathogenic bacteria, such as Staphylococcus aureus. This research conducted to determine the antibacterial and antioxidant activities of D. trifasciata leaf extracts. The D. trifasciata leaf material was sequentially extracted using sonication, beginning with chloroform and then followed by ethanol. The Kirby-Bauer method was employed to conduct the antibacterial test, wherein the inhibition zones generated by the chloroform and ethanolic extracts were measured. The test bacteria used in this study was Staphylococcus aureus. The assessment of the antioxidant activity was conducted using the DPPH (2,2-diphenyl-1-picrylhydrazyl) method. Phytochemical compound identification in the extracts was conducted using GC-MS analysis. The ethanolic extract showed a higher yield percentage compared to the chloroform extract. Both extracts exhibited moderate antibacterial activity. The chloroform extract exhibited an inhibition zone of 73.33 mm2, while the ethanolic extract showed an inhibition zone of 110 mm2. The chloroform extract had a minimum inhibitory concentration (MIC) of 500 mg/mL and a minimum bactericidal concentration (MBC) of 1000 mg/mL. The ethanolic extract had an MIC of 31.25 mg/mL and an MBC of 62.50 mg/mL. In terms of antioxidant activity, the chloroform extract had an IC50 of 370.8±0.07 µg/mL, while the ethanolic extract had an IC50 of 647.4±0.12 µg/mL. GC-MS analysis revealed 47 compounds in the chloroform extract and 49 compounds in the ethanolic extract. Based on the results of yield, antibacterial and compound identification, the ethanolic extract of D. trifasciata leaves exhibited greater potential compared to the chloroform extract. Its antibacterial activity showed more promise than its antioxidant activity
Perbandingan Variasi Pelarut dari Ekstrak Daun Lidah Mertua (Sansevieria trifasciata) terhadap Rendemen dan Aktivitas Antibakteri Dewatisari, Whika Febria
Prosiding SNPBS (Seminar Nasional Pendidikan Biologi dan Saintek) 2019: Prosiding SNPBS (Seminar Nasional Pendidikan Biologi dan Saintek)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (512.836 KB)

Abstract

Lidah Mertua (Sansevieria trifasciata) memiliki kandungan berbagai macam metabolit sekunder sehingga berpotensi sebagai antibakteri. Salah satu bakteri yang sering menyerang tubuh manusia adalah Escheria coli. Bakteri E. coli merupakan bakteri yang terdapat pada saluran pencernaan manusia dan hewan, namun bakteri ini dapat berubah menjadi oportunis patogen bila hidup di luar usus, misal pada saluran kemih. Dalam penelitian ini dilakukan perbandingan variasi pelarut terhadap rendemen ekstrak Lidah Mertua untuk mendapatkan pelarut yang tepat yang berpotensi sebagai antibakteri. Ekstraksi lidah Mertua dilakukan dengan cara maserasi menggunakan pelarut n-heksan (non polar), aseton (semi polar), dan etanol(polar), menggunakan ekstraksi secara maserasi. Pengujian efektivitas antibakteri ekstrak kasar daun Lidah Mertua dilakukan terhadap bakteri E. coli menggunakan metode sumur difusi. Metode tersebut dilakukan dengan cara mengukur diameter zona bening di sekitar sumuran. Adanya zona bening di sekitar sumuran menunjukkan aktivitas antibakteri. Pelarut yang paling berpotensi sebagai antibakteri dilanjutkan dengan uji KHM (Konsentrasi Hambat Minimum). KHM dilakukan pada konsentrasi 250; 125; 62,5; 31,25; 15,625 mg/mL. Hasil penelitian menunjukkan bahwa etanol merupakan pelarut yang paling berpotensi menghambat pertumbuhan E. coli, hal ini ditunjukkan dengan pembentukan zona bening sebesar 24 mm, 23 mm, dan 24 mm, diikuti oleh n heksan sebesar 19 mm,18 mm, 18mm dan aseton sebesar 18 mm, 17 mm, 15 mm. Nilai KHM ekstrak etanol lidah mertua terhadap bakteri E. coli adalah 125 mg/mL.
Literature Review: Natural Anthelmintic from Moringa Leaves (Moringa oleifera) for Controlling Haemonchus contortus in Goats Wulandari, Aprilia Rizki; Dewatisari, Whika Febria
Jurnal Biologi Tropis Vol. 25 No. 4a (2025): Special Issue
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v25i4a.10939

Abstract

Haemonchus contortus remains one of the most pathogenic gastrointestinal nematodes in goats, causing substantial productivity losses in small ruminant farming. The increasing resistance and residue concerns associated with synthetic anthelmintics highlight the need for safer, plant-based alternatives. This study aims to review the potential of Moringa oleifera leaves as a natural anthelmintic for controlling Haemonchus contortus infections in goats. A non-systematic literature review was conducted by screening scientific articles published between 2019 and 2024 through Google Scholar using keywords related to alternative natural anthelmintics, control of goat parasites, Haemonchus contortus infection, Moringa oleifera, and plant phytochemical compounds. Relevant in vitro and in vivo studies were analyzed descriptively to evaluate the plant’s phytochemical profile, mechanisms of action, and effectiveness. Findings indicate that Moringa oleifera leaves contain tannins, saponins, flavonoids, alkaloids, and terpenoids that inhibit egg hatching, disrupt larval development, and impair adult worm survival. In vitro studies consistently demonstrate high ovicidal, larvicidal, and vermicidal activity, with inhibition rates comparable to albendazole at higher concentrations. In vivo results also show significant reductions in fecal egg counts (FEC), particularly at doses of 200–400 mg/kg body weight, without reported adverse effects. These outcomes underline the effectiveness and safety of Moringa oleifera leaves as a promising natural anthelmintic. In conclusion, Moringa oleifera represents a viable, environmentally friendly option for integrated parasite control in goats, particularly for reducing infections caused by Haemonchus contortus. Further standardized dosing studies and long-term evaluations are recommended to optimize its practical application in small ruminant health management.
Co-Authors Hariyadi, Hariyadi Ismi Rakhmawati Leni Rumiyanti Rakhmawati, Ismi Rumiyanti, Leni To'bungan, Nelsiani Wulandari, Aprilia Rizki Yuliastrin, Adisti