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Dwi Wahyuni Leboe
UIN ALAUDDIN MAKASSAR
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health

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THE POTENTIAL OF SORGHUM BICOLOR L. AS A BLOOD GLUCOSE LOWERING AGENT : A REVIEW Dwi Wahyuni Leboe; Nur Syamsi Dhuha; Munifah Wahyuddin; Nur Rezky Rutami A
Jurnal Kesehatan THE 2nd ALAUDDIN PHARMACEUTICAL CONFERENCE AND EXPO (ALPHA-C) 2020
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/kesehatan.v1i1.18181

Abstract

The increasing mortality rate in Indonesia due to diabetes mellitus is a health problem in the world, especially in Indonesian. Evidenced by prevalence of diabetes mellitus which increases every year and is estimated in 2030 achieved 21,3 million according by WHO. Pharmacological therapy which cost is relatively expensive and can caused side effects from the use of chemical drugs. For this reason, the importance of finding new alternative therapy. Sorghum bicolor L. is a cereal that has high nutritional value and phytochemical compounds. This research purpose to know contain of Sorghum bicolor L. and the mechanisme   Sorghum bicolor L. as a blood glucose lowering agent. In this research is the literature study method based on primary and secondary data obtained. The database obtained is from Google scholar, Science direct, Research gate, NCBI, MDPI by using keywords. And the analysis of 43 journals obtained were scanned and analyzed in more detail by introduction, method, result, and conclusion of each journal . And the made in the data analysis table. Shows that Sorghum bicolor L. can be used as a blood glucose lowering agent because contain antidiabetic compounds, namely is phenolic compounds of phenolic acid, flavanoids, and tannin. And has a low glycemic index value and high fiber. Which can provide hypoglycemic effects and reduce postprandial blood glucose levels because it a slor digestion, slow gastric emptying, can inhibit the activity of digestive enzymes, namely the activity of α-glucosidase and  α- amylase, increasen insulin sensitivity, and inhibits the process of glucogenesis in the liverblood pressure, broken bones, diabetes, malaria, ulcers, vomiting blood, bleeding, appendicitis and lungs.
FORMULASI DAN UJI AKTIVITAS KRIM ANTIOKSIDAN EKSTRAK ETANOL DAUN BINAHONG (Anredera cordifolia (Ten.) Steenis) DENGAN METODE DPPH (1,1-diphenyl-2-picrylhydrazil) Dwi Wahyuni Leboe
Jurnal Farmasi UIN Alauddin Makassar Vol 8 No 2 (2020): Jurnal Farmasi Edisi November
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/jurfar.v8i2.20442

Abstract

Penelitian ini bertujuan untuk mengembangkan produk kosmetik dari bahan alam dengan menggunakan ekstrak etanol Daun Binahong dan mengetahui aktivitas antioksidan ekstrak etanol Daun Binahong dalam sediaan krim dengan metode DPPH (1,1-diphenyl-2-picrilhydrazil). Ekstraksi Daun Binahong dengan metode maserasi menggunakan etanol. Formulasi sediaan krim antioksidan dibuat dengan beberapa variasi konsentrasi FI (0,02 g), FII (0,04 g), FIII (0,06 g), FIV sebagai kontrol negatif dan FV sebagai kontrol positif.Kemudian di uji aktivitas antioksidannya terhadap larutan DPPH dan dihitung rata-rata % peredaman FI 18,49%, FII 63,61%, FIII -8,68%, FIV -36,94% dan FV 61,87%. Dari semua formulasi yang memiliki aktivitas antioksidan yang paling efektif adalah FII dengan konsentrasi ekstrak 0,04 g.Selanjutnya dilakukan evaluasi sediaan krim yaitu pengujian organoleptik, pengujian pH, daya sebar, homogenitas dan daya lekat. Pada pengujian organoleptic dan homogenitas semua formulasi memiliki hasil yang baik. Pada pengujian daya sebar semua sediaan krim tidak memenuhi syarat. Pada pengujian pH sediaan hanya FII, FIII dan FV yang memiliki pH sesuai dengan fisiologis kulit. Pada pengujian daya lekat semua sediaan krim memenuhi syarat.
Co-Authors Munifah Wahyuddin Nur Rezky Rutami A Nur Syamsi Dhuha