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All Journal Jurnal Kesehatan ad-Dawaa : Journal of Pharmaceutical Sciences
Munifah Wahyuddin
UIN ALAUDDIN MAKASSAR
Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health

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THE POTENTIAL OF SORGHUM BICOLOR L. AS A BLOOD GLUCOSE LOWERING AGENT : A REVIEW Dwi Wahyuni Leboe; Nur Syamsi Dhuha; Munifah Wahyuddin; Nur Rezky Rutami A
Jurnal Kesehatan THE 2nd ALAUDDIN PHARMACEUTICAL CONFERENCE AND EXPO (ALPHA-C) 2020
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/kesehatan.v1i1.18181

Abstract

The increasing mortality rate in Indonesia due to diabetes mellitus is a health problem in the world, especially in Indonesian. Evidenced by prevalence of diabetes mellitus which increases every year and is estimated in 2030 achieved 21,3 million according by WHO. Pharmacological therapy which cost is relatively expensive and can caused side effects from the use of chemical drugs. For this reason, the importance of finding new alternative therapy. Sorghum bicolor L. is a cereal that has high nutritional value and phytochemical compounds. This research purpose to know contain of Sorghum bicolor L. and the mechanisme   Sorghum bicolor L. as a blood glucose lowering agent. In this research is the literature study method based on primary and secondary data obtained. The database obtained is from Google scholar, Science direct, Research gate, NCBI, MDPI by using keywords. And the analysis of 43 journals obtained were scanned and analyzed in more detail by introduction, method, result, and conclusion of each journal . And the made in the data analysis table. Shows that Sorghum bicolor L. can be used as a blood glucose lowering agent because contain antidiabetic compounds, namely is phenolic compounds of phenolic acid, flavanoids, and tannin. And has a low glycemic index value and high fiber. Which can provide hypoglycemic effects and reduce postprandial blood glucose levels because it a slor digestion, slow gastric emptying, can inhibit the activity of digestive enzymes, namely the activity of α-glucosidase and  α- amylase, increasen insulin sensitivity, and inhibits the process of glucogenesis in the liverblood pressure, broken bones, diabetes, malaria, ulcers, vomiting blood, bleeding, appendicitis and lungs.
Activity of Bidens Pilosa Herb Infussion as Antiinflammatory Munifah Wahyuddin; Nurdaonah Nurdaonah; Ferawati Ferawati
Ad-Dawaa: Journal of Pharmaceutical Sciences Vol 3 No 1 (2020)
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/djps.v3i1.14004

Abstract

Ajeran (Bidens pilosa), traditionally, was widely used to reduce pain and inflammation. This study aims to determine the activity of Ajeran herb infusion as an anti-inflammatory. Determination of activity using 18 mice which were divided into 6 groups. Blank group (I) was given aquadest, groups II, III, IV and V were given Ajeran dry herb infusion with concentrations 10, 20, 30 and 40% w/v, respectively, and group VI was given sodium diclofenac suspension 0,195 mg/ml, each 1 ml. Inflammation induction was performed by administering eggwhite suspension 1% v/v on the sole of the left foot. Foot volume before and after induction were measured as normal and initial edema volume. After that, the mice were given treatment and measurements of foot volume again at 15, 30, 45 and 60 minutes. The test results showed that the infusion of Ajeran and diclofenac sodium could reduce edema starting at 15 minutes, which were 17.8% (II); 20.6% (III); 22.2% (IV); 25% (V); and 15% (VI). It was different with blank group, the volume of edema did not decrease (0%). At 60 minutes, the volume of edema in all groups higher decreased that at 15 minutes, namely 23.4% (I); 28.9 (II); 35.6 (III); 37% (IV); 41.7% (V); and 30% (VI). The conclusion is that the administration of Ajeran infusion can reduce the volume of edema of feet with inflammation of mice.
Co-Authors Dwi Wahyuni Leboe Ferawati Ferawati Nur Rezky Rutami A Nur Syamsi Dhuha Nurdaonah Nurdaonah