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All Journal Indonesian Journal of Urology Indonesian Journal of Biomedicine and Clinical Sciences
Tanaya Ghinorawa
Department of Urology, Faculty of Medicine/Indonesia University, Cipto Mangunkusumo Hospital, Jakarta.
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

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CORRELATION OF PSA, PV, AND IPP IN DETECTING BOO CAUSED BY PROSTATE ENLARGEMENT Kurnia, Indra Cahya; Ghinorawa, Tanaya; Rochadi, Sungsang
Indonesian Journal of Urology Vol 21 No 2 (2014)
Publisher : Indonesian Urological Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32421/juri.v21i2.34

Abstract

Objective: To define the relationship between intravesical prostatic protrusion (IPP), prostate specific antigen (PSA), and prostate volume (PV), and to determine which one is the best predictor of bladder outlet obstruction (BOO) due to benign prostatic enlargement. Material & method: 95 male patients > 40 years old presenting with LUTS and BPH, between January until July 2012. They were evaluated with digital rectal examination (DRE), International Prostate Symptoms Score (IPSS), total PSA serum, uroflowmetry, post-void residual urine measurement, IPP and PV using transabdominal ultrasound. Statistical analysis included Chi-square and Spearman’s Rank correlation test.Receiver Operator Characteristic (ROC) curves were used to evaluate the correlation of PSA, PV, and IPP with BOO. Results: Mean PSA was significantly higher in obstructed patients (8.6 ng/mL; 0.76-130) compared to non-obstructed patients (6.44 ng/mL; 1.0-40.6). Mean PV was significantly larger in obstructed patients (50.33 mL ± 24.34) compared to non-obstructed patients (45.39 mL ± 23.43). Mean IPP was significantly greater in obstructed patients (7.29 ± 2.78) compared to non-obstructed patients (6.59 ± 2.93). The Spearman rho correlation coefficients were 0.617, 0.721, and 0.797, for PSA, PV, and IPP, respectively. Using ROC curves, the areas under the curve for PSA, PV, and IPP were 0.509, 0.562 and 0.602, respectively. The positive predictive values of PV, PSA, and IPP were 59.7%, 55.6% and 60.2% respectively. Conclusion: PSA, PV, and IPP measured through transabdominal ultrasonography are noninvasive and accessible method that significantly correlates with BOO in BPH patients. IPP is a better predictor for BOO than PSA or PV.Keywords: Bladder outlet obstruction, intravesical prostatic protrusion, prostate specific antigen, prostate volume, transabdominal ultrasound, benign prostate hyperplasia.
RELATION BETWEEN AGING MALE SYMPTOM SCORE (AMS SCORE) AND AGE Ghinorawa, Tanaya; Rahardjo, Djoko
Indonesian Journal of Urology Vol 17 No 2 (2010)
Publisher : Indonesian Urological Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32421/juri.v17i2.346

Abstract

Objective: To study the relation of the Aging Male Symptom Score (AMS score) with age groups, and to find the age when the AMS score increases. Material & method: In all, 347 patients with age beginning at 50 years underwent an interview with the AMS Score questionnaire, then they were divided according to age in groups, less than or equal to 50 years, 51 – 55 years, 56 – 60 years, and more than 60 years. Results: In the age group less than or equal to 50 years, there were 26 men (7,5%). With an abnormal AMS psychology, there were 18 men, with abnormal AMS somatovegetative score there were 20 men, with an abnormal AMS sexual score 20 men, and with abnormal total AMS Score 14 men. In the age group 51 – 55 years, there were 146 men (42,07%), with an abnormal AMS psychology in 75 men, with abnormal AMS somatovegetative score 114 men, abnormal AMS sexual in 123 men, and abnormal total AMS Score in 71 men. In age group 56 - 60 years there were 48 men (13,83%), abnormal AMS psychology in 35 men, abnormal AMS somatovegetative score in 44 men, abnormal AMS sexual in 45 men, and abnormal total AMS Score in 35 men. In the age group of more than 60 years, there were 127 men (36,6%), abnormal AMS psychology was found in 87 men, abnormal AMS somatovegetative score in 112 men, abnormal AMS total sexual score 122 men, and abnormal total AMS score was in 96 men. All of the AMS score values significantly increased after 55 years old, p value at AMS psychology was 0,005, AMS somatovegetative was 0,000, AMS sexual was 0,000, and at total AMS Score was 0,000. To define the age when AMS score increases. The conclusion was that AMS psychology values begin to increase after 55 years (sensitivity 69,71, specificity 45,93), AMS somatovegetative values increase after 55 years (sensitivity 89,14, specificity 22,09), and total AMS score value begins to increase at 55 years (sensitivity 74,86, specificity 50,58). However, AMS sexual value increase at 50 years (sensitivity 90,34, specificity 23,08). Conclusion: All of the AMS score values increase significantly at 55 years.
CLINICAL EVALUATION OF TENCKHOFF CATHETER INSERTION IN PAEDIATRIC PERITONEAL DIALYSIS : A SINGLE CENTER STUDY Nurkholiq, Syahdat; Ghinorawa, Tanaya
Indonesian Journal of Urology Vol 28 No 2 (2021)
Publisher : Indonesian Urological Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32421/juri.v28i2.682

Abstract

Objective: This study aimed to evaluate the clinical outcome of Tenckhoff catheter insertion at Sardjito General Hospital for pediatric renal failure. Material & Methods: Data were collected from January 2014 to December 2018 at Sardjito General Hospital. All patient records were collected retrospectively such as patient characteristics, underlying diseases of kidney failure, congenital abnormalities, surgical technique, complications that occur after Tenckhoff catheter insertion. Results: 45 patients meet the inclusion criteria. A total of 7 patients with acute kidney failure (15.5%) and 38 patients with chronic kidney failure (84.5%). Glomerulonephritis is the most common cause of kidney failure (21 patients, 46.7%). The insertion technique used was open surgery in 34 patients (76%) and laparoscopic insertion in 11 patients (24%). Complications reported were catheter dysfunction, leakage of dialysate, surgical site infection, and peritonitis. Conclusion: Tenckhoff catheter insertion for peritoneal dialysis (PD) in pediatric patients with acute and chronic renal failure performed in our center is effective and safe. The most common cause of renal failure in pediatric is glomerulonephritis. Open surgery and laparoscopic insertion of Tenckhoff catheter both have a low complication rate. Catheter dysfunction due to mechanical catheter obstruction is one of the main problems in the placement of Tenckhoff catheter.
Urethroscopy evacuation of glue stick polyembolokoilomania: a case report Sabudi, I Made Nugraha Gunamanta; Irzan, Muhammad Anwar; Ghinorawa, Tanaya
Indonesian Journal of Biomedicine and Clinical Sciences Vol 57 No 1 (2025)
Publisher : Published by Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/inajbcs.v57i1.17134

Abstract

Insertion of a foreign body is an uncommon case in the urology emergency. It was reported one of the abnormal habits called polyemobolokoilomania, which involves inserting strange things into the self-body orifice, especially the urethra in the urological case. A male 56 yo came with a history of inserting a glue stick on his external urethral orifice and complained of dysuria. By physical examination, palpated solid things 6 cm from the external urethral orifice. The patient then planned to undergo urethroscopy and found the glue stick along 27 cm. Urethroscopy successfully evacuated the whole glue stick, and a silicone catheter 18 Fr was applied to monitor the urine. The next 2 wk, the indwelling catheter was removed, and the patient could normally urinate. Glue stick insertion is one of the things that is commonly inserted by polyembolokoilomania, or the act of insertion a foreign body into a human orifice. Psychological and psychiatric aspects also need to be evaluated, because the patient could have mental health issues that need to be treated to prevent recurrent habits in the future. Physical examination of foreign bodies could be found when palpated along the penis. Further diagnostic tools like BNO could be conducted if there was no clear information from history taking (patient dishonest or unable to communicate) and in doubt by physical examination. The approach to evacuation could be varied, it could be evacuated by a milking procedure, endourology using a urethroscope, or open surgery. Insertion of strange things or polyembolokoilomania was an uncommon case in a urology emergency setting. The treatment focuses on evacuating the foreign body, and the patient can urinate normally. Psychological and psychiatric aspects also need to be followed up to prevent recurrent habits as a risk factor for repeated cases.
COMPARISON OF ANDROGEN AND ESTROGEN RECEPTORS’ EXPRESSION IN DARTOS TISSUE OF BOYS WITH AND WITHOUT HYPOSPADIAS Danurdoro, Aria; Ghinorawa, Tanaya; Yuri, Prahara; Setyo Hariyanto, Didik; Rodjani, Arry; Wahyudi, Irfan; Immanuel Hutasoit, Yonas; Yudha Alfanius Hutahaean, Andre
Indonesian Journal of Urology Vol 30 No 1 (2023)
Publisher : Indonesian Urological Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32421/juri.v30i1.773

Abstract

Objective: This study aims to investigate the characteristics of androgen receptors (AR), estrogen receptor 1 (ER1) and estrogen receptor 2 (ER2) expression in dartos tissue of patients with congenital hypospadias, compared to normal penis. Material & Methods: We harvested 63 dartos tissue consisting of 53 congenital hypospadias that underwent urethroplasty (20 distal and 33 proximal) and 10 normal penis that underwent circumcision as controls from September 2017 to September 2018. The expressions of AR, ER1, and ER2 were measured using Quantitative Real-Time PCR (qPCR). All data were analyzed by Prism 7, and one-way ANOVA tests were used to compare gene expressions between the groups. Results: The mean age was 68.99 (± 45.5) and 65.6 (± 25.8) months in boys with and without hypospadias, respectively. The expression of mRNA AR was decreased in proximal (6.26 ± 2.30) and distal hypospadias (6.43 ± 2.22) compared to controls (9.69 ± 1.10), which were statistically significant (p=0.0001 and p<0.0001, respectively). We found a statistically significant difference of ER1 expression compared to controls (p=0.0064). The expression of ER2 was significantly increased in distal (21.03 ± 5.00) and proximal hypospadias (25.21 ± 8.06) groups compared to controls (11.80 ± 2.49) (p<0.0001). There was no statistically significant mean difference in mRNA ER1 expression (p=0.65). Conclusion: The repressed AR and elevated ER mRNA as shown in our study may suggest that defects in those receptors’ interaction and/or balance may contribute to hypospadias and penile curvature condition. Further studies are needed to evaluate any gene-related problems in hypospadias. Keywords: Hypospadias, androgen receptor, estrogen receptor, dartos tissue.
Co-Authors Arry Rodjani Danurdoro, Aria Djoko Rahardjo Immanuel Hutasoit, Yonas Indra Cahya Kurnia Irfan Wahyudi Irzan, Muhammad Anwar Nurkholiq, Syahdat Prahara Yuri Sabudi, I Made Nugraha Gunamanta Setyo Hariyanto, Didik Sungsang Rochadi Yudha Alfanius Hutahaean, Andre