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Adiansyah
Universitas Sari Mutiara Indonesia
Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Education Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health Social Sciences Other

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UJI AKTIVITAS ANTIBAKTERI HAND SANITIZER DARI EKSTRAK ETANOL BUNGA ROSELLA (Hibiscus Sabdariffa L) TERHADAP PERTUMBUHAN BAKTERI Staphylococcus aureus Adiansyah Adiansyah; Siti Maimunah; Elly Nurita Sitorus; Nurul Hazlinda
Jurnal Farmanesia Vol 5 No 1 (2018): Jurnal Farmanesia
Publisher : UNIVERSITAS SARI MUTIARA INDONESIA

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Abstract

In Indonesia with a tropical climate, rosella can thrive. Roselle plant (Hibiscus sabdariffa L.) is well known for its petals which can be used as a health drink that can cure various diseases. Roselle flower (Hibiscus sabdariffa L.) contains nutritious substances such as alkaloids, flavonoids, tannins, terpenoids, which have antibacterial properties. The purpose of this study was to determine the antibacterial hand sanitizer ethanol extract of Rosella flower (Hibiscus sabdariffa L) had good quality and stability against Staphylococcus aureus bacteria. This research was experimental, including rosella flower sample collection, simplicia drying, extract making using a rotary evaporator, phytochemical screening, characteristics of the antibacterial activity test preparation of hand sanitizer with agar diffusion method using paper discs. Roselle flower ethanol extract can be made as Hand sanitizer in spray preparations and has antibacterial activity. The difference in the concentration of the ethanol extract is 2.5%, the inhibition zone is 6.8 mm, 5% is the inhibition zone is 7.27 mm, 7.5% is the inhibition zone is 7.72 mm and 10% is 12.35 mm. The ethanolic extract of the Roselle flower (Hibiscus sabdariffa L) can be used as a hand sanitizer preparation. It has antibacterial activity against Staphylococcus aureus bacteria and is the most effective at a concentration of 10% of 12.35 mm.
UJI AKTIVITAS ANTIDIABETES EKSTRAK ETANOL DAUN SENDOK (Plantago major L.) PADA TIKUS PUTIH JANTAN YANG DIINDUKSI ALOKSAN Supartiningsih Supartiningsih; Jon Kenedy Marpaung; Adiansyah Adiansyah; Hapsah Junita Siregar
Jurnal Farmanesia Vol 5 No 1 (2018): Jurnal Farmanesia
Publisher : UNIVERSITAS SARI MUTIARA INDONESIA

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Abstract

Spoon leaves contain active ingredients, namely tannins, flavonoids, sterols, and polysaccharides. These compounds may be responsible for providing a hypoglycemic effect. This study aims to determine the characterization of the ethanol extract of spoon leaves in male white rats induced by alloxan. Diabetic rats were grouped into five treatment groups, each group consisted of 5 rats. Group I (CMC-Na suspension 0.5% w/v), group II (glibenclamide 0.45 mg/kg BW); Groups II, III, and IV (EEDS doses of 200 mg/kg BW, 400 mg/kg BW, and 600 mg/kg BW) were taken orally for 15 consecutive days. Furthermore, the measurement of glucose levels was observed and measured with a glucometer on days 3, 5, 7, 9, 11, 13, and day 15. The results of the examination of simplicia characteristics showed that the water-soluble extract content was 13.47%, the ethanol-soluble extract content was 12.84%, the total ash content was 3.29%, and the acid insoluble ash content was 0.29%. The results of the analysis of the administration of EEDS showed a significant effect of reducing blood glucose levels in mice compared to the 1% CMC-Na control group. The best decrease in blood glucose levels on the 15th day was shown in the 600 mg/kg BW dose group. Statistical test results (a = 0.05) showed that EEDS at a dose of 400 mg/kg BW and a dose of 600 mg/kg BW were not significantly different from glibenclamide at a dose of 0.45 mg/kg BW.
FORMULASI SEDIAAN MASKER PEEL-OFF EKSTRAK DAUN PAKIS (Diplazium esculentum (Retz.)sw.) SEBAGAI ANTI-AGING Ahmad Ghazali; Jon Kenedy Marpaung; Adiansyah Adiansyah; Carlos Salinas Sitorus
Jurnal Farmanesia Vol 5 No 2 (2018): Jurnal Farmanesia
Publisher : UNIVERSITAS SARI MUTIARA INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (909.175 KB) | DOI: 10.51544/jf.v5i2.2730

Abstract

Tumbuhan pakis memiliki kandungan flavonoid, vitamin C, vitamin A, vitamin B kompleks, kalsium, dan fosfor. Flavonoid merupakan senyawa utama yang digunakan dalam sediaan masker gel peel-off sebagai anti-aging. Flavonoid mempunyai sifat sebagai antioksidan. Tujuan dari penilitian ini adalah memformulasikan dan mengevaluasi kemampuan masker gel peel-off ekstrak etanol daun pakis (Diplazium esculentum (Retz.)sw.) dalam memberikan efek anti-aging pada kulit wajah. Metode penelitian ini dilakukan secara eksperimental. Ekstrak etanol daun pakis diperoleh dengan cara maserasi menggunakan penyari etanol kemudian dipekatkan dengan rotary evaporator pada suhu 40, kemudian diformulasikan dalam sediaan masker gel peel-off dengan konsentrasi 2,5% (formula 1), 5% (formula 2), dan 7,5% (formula 3). Evaluasi terhadap sediaan masker gel peel-off meliputi pemeriksaan organoleptis, homogenitas, pengamatan stabilitas sediaan (perubahan warna, bau, pH dan waktu sediaan mongering dikulit) selama penyimpanan 4 minggu, uji viskositas, uji iritasi, dan uji efektifitas menggunakan alat skin analyzer terhadap kulit wajah. Parameter yang diukur meliputi kadar air, besar pori, jumlah noda, dan keriput. Perawatan dilakukan selama 4 minggu.Hasil penilitian menunjukkan bahwa ekstrak etanol daun pakis dapat diformulasikan sebagai masker gel peel-off. Hasil pemeriksaan kadar air yang terbaik adalah 7,5%, pori yang terbaik adalah 7,5%, penurunan noda yang terbaik pada konsentrasi 7,5%, dan penurunan keriput yang terbaik pada konsentrasi 5% terhadap pemakaian selama empat minggu.
ANALISA KADAR CEMARAN MERKURI (Hg) PADA IKAN TUNA (Thunnus sp.) KEMASAN KALENG SECARA SPEKTROFOTOMETRI SERAPAN ATOM (SSA) Adiansyah Adiansyah; Yosy Cinthya Eriwaty Silalahi; Sanjaya Abdi L. G
Jurnal Farmanesia Vol 6 No 2 (2019): Jurnal Farmanesia
Publisher : UNIVERSITAS SARI MUTIARA INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (667.521 KB) | DOI: 10.51544/jf.v6i2.2750

Abstract

Mercury is a heavy metal that can have a toxic effect on the body so that it can cause death. Mercury metal contamination in food is regulated in SNI number 7387 of 2009 regarding the Maximum Heavy Metal Limit. Some metal waste disposal ends up in river, lake, or sea waters so that metal pollution can occur in the ecosystem. This study aims to determine the levels of mercury metal contamination in canned tuna. Sample preparation was carried out using the wet digestion method with a microwave digestion device. The results of the analysis showed that from the six samples of canned tuna fish according to the maximum limit and meet the standard maximum limit of 1.0 mg/kg SNI. Mercury analysis was carried out using the AAS (Atomic Absorption Spectrophotometry) method. The wavelength used is at 253.7 nm. The results showed that the mercury in tuna brand A was 0.9030±0 mg/kg tuna brand B 0.1029±0 mg/kg, tuna brand C 0.4524±0 mg/kg, tuna brand C D 0.0967±0 mg/kg, tuna brand E 0.9567 ± 0 mg/kg, and tuna brand F 0.8034±0 mg/kg.
FORMULASI DAN EVALUASI SEDIAAN PERONA PIPI (Blush on) CREAM DARI EKSTRAK ETANOL BIJI BUAH TERONG BELANDA (Solanum betaceumCav.) SEBAGAI PEWARNA ALAMI Adiansyah Adiansyah; Eka Margaret Sinaga; Lestari Sitohang
Jurnal Farmanesia Vol 6 No 2 (2019): Jurnal Farmanesia
Publisher : UNIVERSITAS SARI MUTIARA INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (261.73 KB) | DOI: 10.51544/jf.v6i2.2751

Abstract

Tamarillo contains red anthocyanin pigments which can be used as an alternative natural dye. The purpose of this study was to formulate a blush preparation from Tamarillo (Solanum betaceum) seed extract in the form of a cream and to determine the ethanol extract of Tamarillo(Solanum betaceum) seeds can be used as a natural dye in the formulation of a cream blush preparation. The study used Tamarillo seed extract with concentrations of 3.75%, 5%, 7, 5%. Data analysis used descriptive analysis by presenting the frequency distribution table of each study. The results obtained indicate that all preparations, namely blanks, preparations with concentrations of 3.75%, 5%, and 7.5% have good organoleptic, meet the requirements of the homogeneity test, have good stability during storage, meet the requirements of the smear power test, meet the requirements for skin pH requirements, not irritating to the skin and the most preferred by panelists is a formula with a concentration of 7.5%. The conclusion of this preparation is that the blush preparation from the ethanol extract of the Tamarillo seeds is good and the most preferred is the color of the preparation with a concentration of 7.5%.
FORMULASI SEDIAAN BLUSH ON DARI SARI BUAH STROBERI (Fragaria vesca L) SEBAGAI PERONA PIPI Artha Yuliana Sianipar; Siti Nurbaya; Adiansyah Adiansyah; Eva Priasanti Sitanggang
Jurnal Farmanesia Vol 7 No 1 (2020): Jurnal Farmanesia
Publisher : UNIVERSITAS SARI MUTIARA INDONESIA

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Abstract

Colorisone of the determining factors for the quality of cosmetics. The use of synthetic colors in blus her can cause irritation on facial skin. Because of that, wetried to make a blush preparation using natural dyes, namely strawberries (Fragariavesca L). The purpose of this study was to make blushusing natural dyesfromstrawberries (Fragariavesca L). The juice is obtaineddirectly using a juicer machine, then heated in a waterbath /Waterbath to obtain a thick juice of strawberry fruit (Fragariavesca L) with a concentration of 15; 25; 35%. The resultsshowedthatthepreparationwashomogeneous, remainedstable, did not cause irritation, wassafe for the skin because thep Hofthepreparation was still in the normal skin phrange of 4.5-6.5, and was quiteliked by the respondents. The conclusion of this study shows that strawberry juice (Fragariavesca L) canbeused as a blush (blush), but the resulting colorisless visible.
DAYA ADSORPSI KARBON AKTIF DARI KULIT SALAK (Salaccazalacca) UNTUK MENURUNKAN KADAR ASAM LEMAK BEBAS PADA MINYAK GORENG CURAH Adiansyah Adiansyah; Yosy Cinthya Eriwaty Silalahi
Jurnal Farmanesia Vol 8 No 1 (2021): Jurnal Farmanesia
Publisher : UNIVERSITAS SARI MUTIARA INDONESIA

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Abstract

Cooking oil is one of the basic human needs as a good processing media. The repeated use of cooking oil by heating at hight temperatures will produce aldehydes,ketones, hydrocarbons, alcohol and rancid odors, which will affect the quality and nutrition of fried foods. An alternative in the form of processing used cooking oil is through the process of adsorption by activated carbon from bark of zalacca fruits. This study aims to make activated carbon from the bark of zalacca fruit in accordance with SNI 06-37300-95 to determine the characteristics of water content, volatile matter content, total ash content, and carbon content by studying effect of this type of activator on the efficiency in decreasing the content of free fatty acids in cooking oil that have been established by SNI 7709:2012. Determination of freefatty acid levels was carried out by alkalimetric acid titration method. The measurement process was carried out on a sample of cooking oil before frying, after the first, second and third frying before and after purification using activated carbon from the bark of zalacca fruits. The results showed that the levels of free fatty acids were reduced after purification, i.e. before frying from 0,2601% to 0,1420%, on the first frying from 0,3571% to 0,1961%, on the second frying from 0,4826% to 0,2431%, and on the third frying from 1,3845% to 0,2186%. Based on the results of the study it appears that the use of activated carbon from bark of zalacca fruit which is activated by 0,1 N HCL, to improve the quality of used cooking oil, is very effective in reducing the levels of free fatty acids in cooking oil in accordance with quality standard of cooking oil by SNI 7709:201, which is a maximum of 0,3 %.
AKTIVITAS PENGHAMBATAN ENZIM PROTEASE 6LU7 VIRUS SARS-COV-2OLEH SENYAWA FLAVONOID DARI TUMBUHAN GENUS ARTOCARPUS SECARA IN SILICO Adiansyah Adiansyah; Dumartina Hutauruk; Lastry Derliana Nainggolan
Jurnal Farmanesia Vol 8 No 2 (2021): Jurnal Farmanesia
Publisher : UNIVERSITAS SARI MUTIARA INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (552.208 KB) | DOI: 10.51544/jf.v8i2.2789

Abstract

The genus Artocarpus is one of the genera of Moraceae plants, this genus consists of 50 species and 40 species of them are found in Indonesia. Several studies have reported that the flavonoid compounds contained in the genus Artocarpus have cytotoxic, antiproliferative, antimalarial, anti-inflammatory, and antioxidant properties. The purpose of this study was to determine the inhibitory activity of the protease enzyme 6LU7 of the SARS-COV-2 virus by flavonoid compounds from plants of the genus Artocarpus using the in-silico tethering method. The method used in the in-silico tethering process is carried out using the PLANTS program, validated using the Yasara program, and visualized using the Moe2008 program. The protein model of the 6LU7 Protease Enzyme was downloaded via the Protein Data Bank (PDB) with the code 6LU7. The results of this study indicate that the binding of flavonoid compounds from the genus Artocarpus to the expression of 6LU7 gives valid results in silico. The flavonoid compounds of the Artocarpus genus inhibited the 6LU7 enzyme protein with a higher docking value than each of the comparison drugs and produced 7 amino acid residues that were bound to each other. The conclusion of this study can be concluded that flavonoid compounds from the genus Artocarpus inhibit the expression of 6LU7 protein with a docking score close to the docking score of each comparison drug and 7 amino acid residues are bound to each other.
PEMELIHARAAN PERALATAN KESEHATATAN TENSIMETER, STETOSKOP DAN STERILISATOR Hotromasai Dabukke; Adiansyah; Salomo Sijabat
Ruang Cendekia : Jurnal Pengabdian Kepada Masyarakat Vol. 1 No. 1 (2022): Ruang Cendekia: Jurnal Pengabdian Masyarakat
Publisher : ARKA INSTITUTE

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (323.772 KB) | DOI: 10.55904/ruangcendekia.v1i1.14

Abstract

Peralatan kesehatan sangat banyak digunakan untuk pelayanan kesehatan, oleh karena itu pemeliharaan peralatan kesehatan wajib dilakukan untuk menghindari kesalahan hasil diagnosa.. Tujuan dari kegiatan ini yaitu untuk melakukan pengecekan pada peralatan tersebut seperti untuk mengetahui hasil akurasi dari alat, untuk melakukan pemeliharaan pada setiap bagian alat dan untuk melakukan perbaikan. Pemeliharaan peralatan kesehatan dibagi dua yaitu pemeliharaan terencana, pemeliharaan preventif dan pemeliharaan tidak terencana (korektif) dimana alat tersebut tidak dapat difungsikan. Tensimeter berfungsi merupakan alat yang digunakan untuk mengukur tekanan darah. Stetoskop berfungsi untuk mendengarkan suara organ di dalam tubuh, seperti denyut jantung, nadi, organ pencernaan, dan paru-paru dan Sterilisator berfungsi untuk mensterilkan bakteri, kuman atau mikroba. Setelah dilakukan pengecekan pada alat tensimeter tersebut alat dalam kondisi baik dan layak digunakan. Pengecekan pada alat stetoskop terdapat sumbatan pada filter dan sudah dibersihkan dan dalam kondisi baik. Alat sterlisator dalam kondisi baik setelah dilakukan pemeliharaan dan pengecekan pada heater dan kabel catu daya. Kegiatan ini berlangsung dengan baik dan melakukan pelatihan tentang perbaikan sederhana kepada user untuk melakukan pemeliharaan rutin pada alat tersebut.
PENCAMPURAN POLIETILENA DAN KARET ALAM SIR-3L DENGAN DIVINILBENZENA SEBAGAI PENGKOMPATIBILITAS CAMPURAN TERMOPLASTIK ELASTOMER Adiansyah Adiansyah
JURNAL KIMIA SAINTEK DAN PENDIDIKAN Vol 2 No 1 (2018): Volume 2 Nomor 1 Tahun 2018
Publisher : Program Studi Kimia - Universitas Sari Mutiara Indonesia

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Abstract

Telah dilakukan penelitian pencampuran polietilena dan karet alam SIR-3L dengan divinilbenzena sebagai pengkompatibilizer campuran termoplastik elastomer (TPE). Pencampuran dilakukan tanpa dan dengan penambahan divinilbenzen polietilena/karet alam SIR-3L/dikumil peroksida (b/b) 50 g : 50 g : 1phr, 2phr, dan 3phr. Untuk mengetahui kualitas komposit yang dihasilkan dilakukan analisa uji tarik, diperoleh peningkatan tanpa divinilbenzen maksimum pada variasi konsentrasi polietilena/karet alam SIR-3L/dikumil peroksida adalah 2 phr yaitu kekuatan tarik 2,20 Kgf/mm2 dan kemuluran 12,29 % dan dengan penambahan divinilbenzen diperoleh peningkatan maksimum pada variasi konsentrasi divinilbenzen/dikumil peroksida (b/b) 3 phr : 2phr yaitu kekuatan tarik sebesar 3,31Kgf/mm2 dan kemuluran 28,99 %. Dari hasil analisa SEM diperoleh bahwa penambahan divinilbenzen diperoleh peningkatan permukaan yang lebih rata dan homogen. Dari hasil analisa gugus fungsi dengan FT-IR menunjukkan bahwa campuran divinilbenzen dan polietilena/karet alam SIR-3L/dikumil peroksida hanya merupakan interaksi secara fisik.
Co-Authors Ahmad Gazali Sofwan Ahmad Ghazali Ahmad Hafizullah Ritonga Carlos Salinas Sitorus Cristina Roos Etty Cut Masyithah Thaib Debie Rizqoh Donal Nababan Dumartina Hutauruk Eddy Surya Kaban Eka Margareta Sinaga Elly Nurita Elly Nurita Sitorus Eva Priasanti Sitanggang F Priyulida Hapsah Junita Siregar Hotromasai Dabukke Hotromasari Dabukke Hotromasari Dabukke Hotromasari Dabukke Irmayanti Hutasoit Ivan Elisabeth Purba Jon Kenedy Marpaung Kesaktian Manurung Lastry Derliana Nainggolan Lestari Simanjuntak Lestari Sitohang MYRNAWATI CRIE HANDINI Nurul Hazlinda Otniel Ketaren Pontisari Sitanggang Rika Rosalinda Tampubolon S Sijabat Salomo Sijabat Sanjaya Abdi L. G Sianipar, Artha Yuliana Siti Maimunah Siti Nurbaya Sry Hayati Supartiningsih Supartiningsih Wilda Florent Siregar Yosy Cinthya Eriwaty Silalahi Yosy Cinthya Eriwaty Silalahi Yunita P