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All Journal The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy Jurnal Penyakit Dalam Indonesia
Arya Govinda
Unknown Affiliation
Medicine & Pharmacology

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Chronic Diarrhea Due to Intestinal Amyloidosis Lydia D Simatupang; Kharia Utia; Ari Fahrial Syam; Marcellus Simadibrata; Arya Govinda; Ening Krisnuhoni
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy VOLUME 6, ISSUE 3, December 2005
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24871/63200591-94

Abstract

Amyloidosis is a rare disease, when diagnosed it’s incurable and mostly affect over 40 years old male. Diagnostic is confirmed if histopathologic stained positive with Congo red and evidence of monoclonal protein. Survivals for untreated patients are 13 months in primary amyloidosis but if secondary to other chronic disease and systemic, survival could be 3-4 years. It can not be prevented but when affected, control of the underlying illness can prevent progression of amyloidosis. We report a rare case of a 67 year old male, who came with chronic diarrhea. The stool analysis, there were no negative gram microorganisme found, only food maldigestion and fungus infection. Stool analyze from parasitology department were found microspore, but the stool culture were sterile. The patient underwent colonoscopy which revealed hyperemis mucosa in rectum, sigmoid, descending transverse colon. From the biopsy was concluded intestinal amyloidosis. We treated the patient symptomatically and couldn’t find the underlying inflammatory disease which causes the problem. Keywords:  secondary  amyloidosis,  chronic  diarrhea, malabsorption,  colonoscopy,  protein electrophoresis
Determinan Diagnostik Klinis Defisiensi Vitamin D pada Wanita Berusia Lebih dari 50 Tahun Vera, Vera; Setiati, Siti; Govinda, Arya
Jurnal Penyakit Dalam Indonesia Vol. 2, No. 1
Publisher : UI Scholars Hub

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Abstract

Pendahuluan: Prevalensi deifisiensi vitamin D pada wanita 50 tahun ke atas di Indonesia cukup tinggi namun pemeriksaan kadar vitamin D serum sangat mahal. Oleh karena itu, diperlukan alat penyaring defisiensi vitamin D yang cukup ekonomis dan sederhana untuk dikerjakan di layanan kesehatan primer. Metode: Penelitian ini merupakan penelitian diagnostik, menggunakan desain potong lintang (cross-sectional) sehubungan dengan pengambilan data hanya dilakukan sewaktu saja. Penelitian ini dilakukan di Kotamadia Bandung selama Agustus–Oktober 2012. Pada 240 subjek, dilakukan pengumpulan data berupa karakteristik responden, diabetes mellitus, penyakit ginjal kronik, riwayat jatuh, riwayat fraktur setelah menopause, nyeri tulang, skor paparan sinar matahari, skor proteksi sinar matahari, status gizi, kinerja fisik (5 timed chair-stands dan uji sikap tandem), status kesehatan (jumlah dan derajat berat penyakit kronis), kadar vitamin D serum. Untuk pengujian statistik hubungan antara dua variabel kualitatif dikotom dilakukan dengan uji Chi-square dilanjutkan dengan uji multivariat. Hasil: Penelitian ini menemukan hubungan yang bermakna secara statistik antara diabetes mellitus, skor proteksi matahari, kelemaan otot ekstremitas bawah dengan defiisensi vitamin D. Berdasarkan ketiga determinan tersebut, dapat dibuat sistem skoring yang dapat digunakan untuk menyaring kelompok wanita 50 tahun ke atas yang mempunyai probabilitas besar menderita defisiensi vitamin D. Simpulan: Determinan diagnostik defisiensi vitamin D berat yang ditemukan pada penelitian ini meliputi: adanya diabetes melitus, skor proteksi matahari, kelemahan otot tungkai bawah. Sistem skoring untuk menyaring defisiensi vitamin D berat pada wanita berusia 50 tahun ke atas dapat dibuat berdasarkan ketiga determinan tersebut di atas. Bobot untuk masing-masing determinan adalah: 1 untuk diabetes mellitus dan kelemahan otot tungkai bawah serta 2 untuk skor proteksi matahari. Bila penjumlahan dari skor ketiga komponen tersebut ³2, maka subjek tersebut diprediksi menderita defisiensi vitamin D berat.
Potassium-Competitive Acid Blocker sebagai Alternatif Penghambat Pompa Proton untuk Mengatasi Gejala Gastroesophageal Reflux Disease: Sebuah Laporan Kasus Berbasis Bukti Prabata, Adam; Prahasary, Adelia Nova; Govinda, Arya
Jurnal Penyakit Dalam Indonesia
Publisher : UI Scholars Hub

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Abstract

Gastric acid suppression is one of the main pillars of gastroesophageal reflux disease (GERD) treatment. Proton pump inhibitor (PPI) is the most used drug for suppressing gastric acid in GERD patients currently. Potassium- acid competitive acid blocker (PCAB) is a new class of drug which can be used as an alternative drug for suppressing gastric acid, so hypothetically, this drug could be an alternative of PPI for relieving GERD symptoms. However, the ability of PCAB for relieving GERD symptoms was not established, so this study was aimed to elucidate the ability of PCAB as an alternative drug of PPI for relieving GERD symptoms. Comprehensive literature searching was conducted in several databases such as PubMed, Embase, Cochrane, EBSCO, and Proquest with keywords “GERD”, “PCAB”, “PPI” dan “symptoms” on September 16-20, 2023. Early literature searching comprised 229 articles then selected based on clinical question and eligibility criteria to get 3 articles to be appraised critically. Vonoprazan, one of PCAB, was using as the main therapy in all of selected studies. Two randomized control trial (RCT) studies showed the non-inferiority of vonoprazan compared to PPI for relieving GERD symptoms. On the other hand, one systematic review and meta-analysis study showed that vonoprazan was superior than PPI for relieving GERD symptoms. This evidence-based case report (EBCR) shows that vonoprazan is non-inferior, even superior, compared to PPI for relieving GERD symptoms. Further, extensive, and larger researches is still needed to support this evidence and the using of PCAB as main and routine treatment for GERD patients.
Co-Authors Ari Fahrial Syam Ening Krisnuhoni Kharia Utia Lydia D Simatupang Marcellus Simadibrata Marcellus Simadibrata Prabata, Adam Prahasary, Adelia Nova Siti Setiati vera vera, vera