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All Journal Medical Journal of Indonesia Journal of Dentistry Indonesia Paediatrica Indonesiana Molecular and Cellular Biomedical Sciences (MCBS) Alami Journal (Alauddin Islamic Medical) Journal Majalah Kedokteran Andalas Majalah Patologi Indonesia Indonesian Journal of Cancer The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy Jurnal Penyakit Dalam Indonesia Kesmas: Jurnal Kesehatan Masyarakat Nasional (National Public Health Journal)

Ening Krisnuhoni

Department Of Anatomic Pathology, Faculty Of Medicine, Universitas Indonesia/Dr. Cipto Mangunkusumo General National Hospital, Jakarta

Author-ID : 300209

Biochemistry, Genetics & Molecular Biology Dentistry Education Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

Published : 34 Documents Claim Missing Document

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Oral Hairy Leukoplakia: Clinical Indicator of an Immunosuppressive Condition and Challenges in Patient Management Agustina, Yohana Alfa; Wardhany, Indriasti Indah; Wimardhani, Yuniardini Septorini; Krisnuhoni, Ening; Iamaroon, Anak
Journal of Dentistry Indonesia Vol. 23, No. 2
Publisher : UI Scholars Hub

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Oral hairy leukoplakia (OHL) is defined as an asymptomatic white patch with vertical corrugation pattern the lateral borders of the tongue, that is associated with Epstein-Barr Virus (EBV) infection. Generally, it is related to immunosuppressive condition found in HIV-positive patients and patients undergoing immunosuppressive therapy. Sometimes, its clinical appearances could mimic other white lesions. Although most OHL cases are found in HIV seropositive individuals, finding in the immunocompetent individuals has also been reported. Appropriate clinical evaluations and laboratory investigations are important for patient’s comprehensive management. Objective: To report a finding of oral hairy leukoplakia as a clinical indicator of an immunosuppressive condition in otherwise a clinically healthy-looking individual and to discuss the challenges on patient management. Case Report: A 40 yearold man presented with asymptomatic, bilateral homogenous white hyperkeratotic plaques with a hairy appearance located on the dorsal of the tongue, extended to the lateral tongue mucosa. The patient failed to remember the lesion’s first appearance, until three weeks before a visit. Working diagnosis of OHL was made with differential diagnoses including white sponge nevus, leukoplakia and oral lichen planus. Histopathological assessment was consistent with OHL. Challenges on patient management include identifying possible risk factors and assuring patient for HIV testing. Conclusion: This case reported findings of OHL as the first clinical indicator of immunosuppressive condition that might be related to HIV-infection.

Hubungan Imunoekspresi Î²-Catenin antara Karsinoma Sel Skuamosa Oral Derajat Rendah dan Derajat Tinggi Berdasarkan Sistem Grading Bryne. Welly Hartono Ruslim; Ening Krisnuhoni; Kusmardi Suid
Majalah Patologi Indonesia Vol 23 No 3 (2014): MPI
Publisher : Perhimpunan Dokter Spesialis Patologi Indonesia (IAPI)

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Background Î²-catenin is an important protein in cellular adhesion and signal transduction. In unstimulated condition, Î²-catenin only appears on the cellular membrane. Altered expression of Î²-catenin has been associated with progressiveness and metastatic process of malignancy in human. The aim of this study was to evaluate the expression of Î²-catenin on oral squamous cell carcinoma (OSCC) and also to assess its different expression in low grade and high grade lesions based on Bryne grading system. Methods This study was conducted on 2 groups of OSCC which included 20 cases of low grade and 20 cases of high grade. Immunohistochemistry staining of Î²-catenin was used to identify the difference of its expression in cell membrane, cytoplasm, and nuclei on invasive tumor front. Results The expression of Î²-catenin on cell membrane, cytoplasm, and nuclei showed significant difference between low and high grade OSCC (p=0.000; p=0.005; and p=0.035, respectively). There has not been any significant association between Î²-catenin expression with age, sex, and tumor location. Conclusion Expression of Î²-catenin could showed morphological change the OSCC. Key words : Î²-catenin, Bryne grading, oral squamous cell carcinoma (OSCC).

Analisis Peran p53 pada Astrositoma Difus dan Astrositosis: Studi Diagnostik Eka Susanto; Esti DS Soetrisno; Nurjati C Siregar; Ening Krisnuhoni; Primariadewi Rustamadji
Majalah Patologi Indonesia Vol 26 No 1 (2017): MPI
Publisher : Perhimpunan Dokter Spesialis Patologi Indonesia (IAPI)

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Latar belakang Astrositoma difus (WHO grade II) merupakan tumor astrositik yang paling sering ditemukan di FKUI/ RSCM. Tumor ini merupakan tumor invasif, potensial agresif, dan dapat bertransformasi menjadi astrositoma derajat tinggi. Pada praktik sehari-hari, diagnosis astrositoma difus kadang-kadang sulit ditegakkan hanya dengan gambaran histopatologik. Hal ini terutama disebabkan karena astrositoma difus sukar dibedakan dengan astrositosis, apalagi bila ukuran spesimen biopsi sangat kecil. Beberapa penelitian menunjukkan bahwa mutasi gen TP53 sering ditemukan pada astrositoma difus. Penelitian ini dilakukan untuk menganalisis pulasan imunohistokimia p53 dalam membedakan astrositoma difus (WHO grade II) dengan astrositosis. Metode Studi diagnostik dilakukan pada 20 kasus astrositoma difus dan 20 kasus lesi astrositosis dengan baku emas pemeriksaan histopatologi. Penilaian histopatologi dan ekspresi p53 dinilai secara tersamar. Pulasan imunohistokimia dinyatakan dalam skor, yaitu positif bila inti astrosit terwarnai coklat tua. Hasil penilaian ekspresi pulasan p53 dimasukkan ke dalam Tabel 2x2 untuk dihitung nilai diagnostiknya. Hasil Protein p53 terekspresi kuat pada 13 kasus astrositoma difus dan 1 kasus astrositosis karena peradangan. Dengan demikian didapatkan sensitivitas 65% dan spesifisitas 95%. Terdapat 2 kasus astrositosis yang positif kuat pada endotel dan makrofag. Ekspresi lemah dan sedang tidak terbatas pada astrositoma difus, namun dijumpai pula pada kasus astrositosis. Kesimpulan Pada penelitian ini di dapatkan spesifisitas yang cukup tinggi, namun sensitivitas masih rendah. Ekspresi p53 tidak terbatas pada astrosit neoplastik, tapi juga dijumpai pada astrosit reaktif dan sel selain astrosit. Oleh karena itu diperlukan kehati-hatian dalam interpretasi ekspresi p53. Kata kunci: astrositoma difus, astrositosis, imunohistokimia, p53.

Gastorintestinal stromal tumor: gambaran klinik, histopatologik dan imunohistokimia Wiwit Ade Fidiawati; Ening Krisnuhoni
Majalah Patologi Indonesia Vol 19 No 1 (2010): MPI
Publisher : Perhimpunan Dokter Spesialis Patologi Indonesia (IAPI)

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ABSTRAKLatar BelakangTumor mesenkimal traktus gastrointestinal mempunyai gambaran histopatologik yang sulit untukdibedakan. Tumor tersebut dapat berasal dari otot dan saraf maupun campuran keduanya.Beberapa tahun belakangan ini tumor mesenkimal traktus gastrointestinal dinyatakan berasal dariIntertitial Cells of Cajal (ICC) dan disebut sebagai Gastrointestinal Stromal Tumor (GIST).Bahan dan caradata arsip Departemen Patologi Anatomik selama dua tahun (2006-2007) terdapat 25 kasus yangdidiagnosis sebagai GIST dengan pulasan Hematoxillin & Eosin, CD117, CD34, S100 dan SMA.Langkah berikutnya dilakukan analisis gambaran klinik, histopatologik dan imunohistokimia.HasilDari 25 kasus GIST, 84,9% terdapat pada pria dan usia terbanyak antara 40-49 tahun. Gastermerupakan lokasi GIST tersering (72%), kemudian diikuti oleh usus kecil (16%), usus besar (8%)dan esophagus (4%). Gambaran histopatologik yang terbanyak adalah subtipe sel kumparan(52%), kemudian subtype campuran (28%) dan subtype epiteloid (20%). GIST dengan diferensiasisaraf merupakan jenis diferensiasi terbanyak, kemudian diikuti oleh GIST yang tidakberdiferensiasi, berdiferensiasi otot polos dan GIST berdiferensiasi campuran otot polos dan saraf.KesimpulanPada penelitian ini, kasus GIST lebih banyak terdapat pada pria dan lokasi tersering adalah gaster.Sub tipe histopatologik terbanyak adalah subtipe spindel dan diferensiasi saraf merupakandiferensiasi tersering. Diagnosis GIST dapat ditegakkan bila sel tumor positif dengan pulasanCD117.

Perbedaan Profil Histomorfologik Jaringan Hati Resipien dan Donor Pascatransplantasi Hati Anak antara Kelompok Pasien Rejeksi dan Tidak Rejeksi di Departemen Patologi Anatomik FKUI/RSCM Periode 2010-2019 Alif Gilang Perkasa; Marini Stephanie; Nur Rahadiani; Diah Rini Handjari; Ening Krisnuhoni; Hanifah Oswari
Majalah Patologi Indonesia Vol 31 No 1 (2022): MPI
Publisher : Perhimpunan Dokter Spesialis Patologi Indonesia (IAPI)

BackgroundLiver rejection is an immune system response of recipient in which attacking the antigen originating from a donor that can causedamage to the transplanted organ. Although the prevalence of liver rejection has decreased due to the use of immunosuppressivedrugs, it is estimated that 20-40% of recipients still experience rejection and are at risk of re-transplantation and even death. Thisstudy aims to investigating histomorphological characteristics that can play a role as risk factors for rejection by assessing thedifferences in histomorphological characteristics before transplantation between recipient groups with rejection and non-rejection inpediatric liver transplant recipients in the Department of Anatomical Pathology, Faculty of Medicine, University of Indonesia, Dr.Cipto Mangunkusumo (PA-FKUI/RSCM)MethodsThis study was an analytical study with a cross sectional design, using secondary data from the archives of the Department ofAnatomical Pathology, Faculty of Medicine, University of Indonesia, Dr. Cipto Mangunkusumo 2010-2019. The clinical andhistopathologic data obtained were analyzed using comparative statistical tests.ResultsRejection were found in 25% of recipients. Rejection were more common in the group of recipients aged >1 (75%), male (58%),cirrhosis 4C (92%) and mild portal inflammation (56%). Rejection were more common in the group of donor with male (66%) andsteatosis ≤10% (92%). There were no significant differences in the histomorphological profiles of recipients and donors with orwithout rejection.ConclusionThe histomorphologic profiles of both recipients and donors were known to be descriptively associated with complications of posttransplant liver rejection. However, in terms of analysis, there was not any significant differences

Reflux esophagitis in children with feeding problems: A preliminary study Lia Mulyani; Badriul Hegar; Alan R. Tumbelaka; Ening Krisnuhoni
Paediatrica Indonesiana Vol 50 No 5 (2010): September 2010
Publisher : Indonesian Pediatric Society

Background Untreated gastroesophageal reflux can cause reflux esophagitis, a condition characterized by damage to the esophageal mucous layer due to exposure to caustic gastric contents. Manifestation of esophagitis in young children include feedingproblems, irritability, and backô€€³arching. Persistent esophagitis may cause growth failure, gastric bleeding, and anemia. Reflux esophagitis should be considered an etiology of feeding problems, especially in children with a history of gastroesophageal reflux during infancy.Objective The purpose of this study is to detennine the prevalence of reflux esophagitis in children with feeding problems.Methods A cros-sectional study was done in November 2007 to April 2008. Children under 5 years of age with feeding problems and a history of regurgitation or vomiting started from age 6 months or more underwent endoscopy and biopsy examinations. Reflux esophagitis was diagnosed based on the Los Angeles classification of endoscopic examination.Results Reflux esophagitis was diagnosed in 18 of 21 children with feeding problems and a history of regurgitation or vomiting. Most subjects were boys aged 12 to36 months. Feeding problems has lasted for more than 6 months, regurgitation or vomitingfor more than 12 months, and suffered from mild malnutrition. Vomiting was observed to be a common symptom in children with reflux esophagitis.Conclusion The prevalence of reflux esophagitis in children with feeding problems and a history of regurgitation or vomiting started from age â‰¥ 6 months is high, therefore it will influence treatment.

Perbandingan Berat Hati Tikus Spraque Dawley yang Diberikan Diet Kurang Kalori, Cukup Kalori, dan Tinggi Kalori pada Masa Pertumbuhan Jelita Inayah Sari; Ahmad Aulia Jusuf; Ening Krisnuhoni
Alami Journal (Alauddin Islamic Medical) Journal Vol 2 No 2 (2018): JULY
Publisher : Universitas Islam Negeri Alauddin Makassar

Perlemakan hati merupakan penyakit degeneratif yang dapat berkembang pada masa pertumbuhan. Perlemakan hati dapat terjadi pada dua kondisi yang sangat berbeda jauh secara patofisiologi yaitu kondisi kekurangan kalori dan kelebihan kalori. Penelitian ini bertujuan untuk membandingkan ukuran berat hati pada pemberian diet tinggi kalori, cukup kalori, dan rendah kalori pada tikus selama masa pertumbuhan. Sampel penelitian menggunakan 15 organ hati Spraque Dawley usia 6 minggu yang diberi asupan kalori berbeda selama 8 minggu. Penelitian ini terdiri atas 3 (tiga) kelompok yaitu kelompok kurang kalori (KK), kelompok cukup kalori (CK), dan kelompok tinggi kalori (TK). Parameter penelitian adalah pemeriksaan berat hati utuk menilai hepatomegaly. Hasil penelitian menunjukkan kelompok TK mengalami kenaikan berat hati ±20% lebih besar dibandingkan dengan kelompok CK dan kelompok KK (p<0,05). Penelitian ini menyimpulkan bahwa diet tinggi kalori dapat menyebabkan terjadinya hepatomegaly.

Choline-deficient High-fat Diet-induced Steatohepatitis in BALB/c Mice Saut Horas Hatoguan Nababan; Seruni Tyas Khairunissa; Erni Erfan; Nafrialdi Nafrialdi; Ening Krisnuhoni; Irsan Hasan; Rino Alvani Gani
Molecular and Cellular Biomedical Sciences Vol 5, No 2 (2021)
Publisher : Cell and BioPharmaceutical Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21705/mcbs.v5i2.193

Background: Non-alcoholic steatohepatitis (NASH) is an expanding cause of chronic liver disease worldwide, including Indonesia, with higher risk progression to cirrhosis and hepatocellular carcinoma. Preclinical experiments using several mice models have been conducted to clarify its complex pathogenesis. This study was designed to investigate whether BALB/c mice on a choline-deficient high-fat diet can be used as a model for NASH. Materials and Methods: BALB/c male mice were fed choline-deficient L-amino acid-defined high-fat diet (CDAHFD) or a standard diet for six weeks. The body and liver weights, liver histology, and plasma biochemistry were analyzed. The relative expression levels of tumor necrosis factor (TNF)α, transforming growth factor (TGF)β1, collagen-1α1 (COL1α1), glutathione peroxidase 1 (GPx1), and uncoupling protein 2 (UCP2) genes in the livers were analyzed using a two-step real time-polymerase chain reaction. Liver fatty acids composition was analyzed using gas chromatography with flame ionization detector (GC-FID). Results: CDAHFD induced steatohepatitis in BALB/c mice with increased plasma levels of alanine aminotransferase. The liver of CDAHFD-fed BALB/c mice showed upregulated relative expression levels of TNFα, TGFβ1, COL1α1, GPx1, and UCP2 genes. The liver fatty acid analysis showed a significant accumulation of saturated fatty acids (SFAs) and an increased ratio of n-6/n-3 polyunsaturated fatty acids (PUFAs) in the livers of CDAHFD-fed BALB/c mice. Conclusion: This study suggests that CDAHFD can induce steatohepatitis in BALB/c mice and therefore may be used as NASH mice model.Keywords: steatohepatitis, fatty liver, choline-deficient high fat diet, BALB/c

Ekspresi HER2/neu(c-ErbB2) pada Kanker Kolorektal Nita Afriani; Ening Krisnuhoni; Nur Rahadiani
Majalah Kedokteran Andalas Vol 37 (2014): Supplement 2 | Published in December 2014
Publisher : Faculty of Medicine, Universitas Andalas

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Kanker kolorektal merupakan keganasan pada kolon dan rektum, penyebab morbiditas danmortalitas ketiga terbanyak diantara keganasan lainnya. Penelitian ekspresi HER2 pada kankerkolorektal memiliki rentang yang cukup jauh yaitu 0-83% dan belum pernah dipublikasi dilndonesia. Penelitian ini bertujuan untuk menilai ekspresi HER2 pada kanker kolorektal. Studicross-secfiona/ dilakukan terhadap 51 sediaan blok parafin kanker kolorektal rentang tahunJanuari 2011-Desember 2012 di Departemen Patologi Anatorni RS Cipto MangunkusumoJakarta. Penilaian karakteristik sampel diambil dari rekam medis dan penilaian histopatologidari sediaan HE pasien kanker kolorektal. Pulasan imunohistokimia HER2 menggunakanantibodipoliklonalantiHER2(DAKO). Rata-rata usia penderita adalah 57.8t13.54tahun,58.8%penderita adalah laki-laki dan 41.2o/o perempuan. Semua sediaan adalah adenokarsinomakolorektal. Ekspresi HER2 positif ditemukan sebanyak 5(9.8%) kasus.AbstractColorectal cancer is a neoplasia of colon and rectum ,and also the 3rd leading cause ofmorbidity and mortality among men and women in the world. HER2 expression has controversialresults ranging from 0-83% and never been pubiished in lndonesia. This research aims tostudy HER2 expression in colorectal cancer. Cross-sectional study was conducted in 51 casesof colorectal cancer from January 2011 until December 2012 in Pathology Department ofCipto Mangunkusumo Hospital. Patient characteristic was reviewed from medical record andhistopathologic was evaluated from HE slides. lmunohistochemistry staining used anti HER2polyclonal antibody frorn DAKO. Mean age was 57.8113.54 years, 58.8% were males and41.2o4 were females. Positive HER2 was 5 cases (9.8%).

Comparison of Helicobacter pylori Detection Using Immunohistochemistry and Giemsa and Its Association with Morphological Changes in Active Chronic Gastritis Wildawati Nurdin; Ening Krisnuhoni; Kusmardi Kusmardi
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy Vol 17, No 1 (2016): VOLUME 17, NUMBER 1, April 2016
Publisher : The Indonesian Society for Digestive Endoscopy

Background: Gastritis is an inflammation of the gastric mucosa as a response to infection or irritation of the gaster. The most common aetiology of chronic gastritis is Helicobacter pylori (H. pylori) infection. Presence of H. pylori is associated with the occurrence of inflammation, atrophy, and intestinal metaplasia. In terms of morphology, H. pylori is known in 2 forms, which are rod-shaped and coccoid-shaped. Coccoid-shaped bacteria are difficult to detect using Giemsa staining. Therefore, immunohistochemistry staining of H. pylori and evaluation of the sensitivity of coccoid-shaped of H. pylori are needed.Method: Cross-sectional study on 90 biopsy tissues of chronic gastritis patients in year 2015 and 2014, which included 30 Giemsa cases with positive H. pylori, 30 cases of active chronic gastritis with negative H. pylori but coccoid-shaped was found, and 30 non-active chronic gastritis, were subsequently stained with immunohistochemistry staining of H. pylori.Results: Expression of coccoid-shaped H. pylori in active chronic gastritis was significantly different (p 0.05) in immunohistochemistry staining. There was a significant difference between active chronic gastritis with positive H. pylori and negative H. pylori in immunohistochemistry staining with degree of inflammation. Sensitivity and specificity test between Giemsa and immunohistochemistry staining showed sensitivity of 65% and specificity of 100%.Conclusion: Immunohistochemistry staining in active chronic gastritis was more sensitive compared to Giemsa staining in detecting H. pylori, particularly the coccoid-shaped bacteria.

Co-Authors Abdul Aziz Rani Abdul Aziz Rani Abdullah, Arman Adel Achmad Fauzi ACHMAD FAUZI Adang Bachtiar Agustina, Yohana Alfa Ahmad Aulia Jusuf Ahmad Soefyani Alan R. Tumbelaka Alif Gilang Perkasa Ari Fahrial Syam Arman Adel Abdullah Aru W. Sudoyo Ary H. Reksodiputro Arya Govinda Badriul Hegar Bethy Hernowo Chudahman Manan Chudahman Manan Chyntia Olivia Maurine Dadang Makmun Dadang Makmun Daldiyono Daldiyono Daldiyono Daldiyono Daldiyono Hardjodisastro Darmawan Kartono David Handojo Muljono Devy Serevina Dewantoro, Okto Dhuhani, Ika Diah Rini Handjari Diah Rini Handjari Diah Rini Handjari Diah Rini Handjari Diah Rini Handjari Dyonesia Ary Harjanti Eka Susanto Elisabeth Indria Sari Elisabeth Indria Sari Erni Erfan, Erni Esti DS Soetrisno Farida Briani Sobri Fili Sufangga Flora Dameria Handayani, Liza Handjari, Diah R. Hanifah Oswari Hutapea, Yuliance Nurhawati I Gusti Ayu Sri Mahendra Dewi I Made Gotra Iamaroon, Anak Ifransyah Fuadi Ifransyah Fuadi, Ifransyah Indriasti Indah Wardhany Irsan Hasan Irwina Eka Deraya Iskandar, Rizka Puteri Jelita Inayah Sari Juwita Cresti Rahmaania Kaka Renaldi Kharia Utia Kuntjoro Harimurti Kusmardi Kusmardi Kusmardi Kusmardi Kusmardi Suid Lia Mulyani Liem, Isabella Kurnia Liza Handayani Lugyanti Sukrisman Lydia D Simatupang Lydia Kencana Manatar, Amelia Fossetta Marcellus Simadibrata Marcellus Simadibrata Marini Stephanie Marini Stephanie Marini Stephanie Marini Stephanie Murdani Abdullah Murdani Abdullah Murdani Abdullah Nafrialdi Nafrialdi Nelly Tandiari Ni Putu Ekawati Nita Afriani Nunung Ainur Rahmah Nur Rahadiani Nur Rahadiani Nur Rahadiani Nur Rahadiani Nurdin, Wildawati Nurjati C Siregar Okto Dewantoro Paskarani, Putu Erika Patria Wardana Yuswar Paulus Kusnanto Permata Warastridewi, Arie Primariadewi Rustamadji Prisscila, Jessica Puspita Eka Wuyung Puspita Eka Wuyung Puspita Eka Wuyung Rabbinu Rangga Pribadi Rahadiani, Nur Rahmaania, Juwita Cresti Reni Oktavina Ria Kodariah Ria Kodariah Rino Alvani Gani Rino Alvani Gani Rino Alvani Gani Rizka Puteri Iskandar Santoso Cornain Santoso Cornain Sari, Elisabeth Indria Saut Horas Hatoguan Nababan Seruni Tyas Khairunissa Sobri, Farida Briani Sonar Soni Panigoro Sufangga, Fili Tandiari, Nelly Velma Herwanto Velma Herwanto Vera Yuwono Welly Hartono Ruslim Wildawati Nurdin Wirasmi Marwoto Wirasmi Marwoto Wiwit Ade Fidiawati Yonathan, I Wayan Murna Yuniardini Septorini Wimardhani Yuswar, Patria Wardana Zakiyah Zakiyah

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