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All Journal Jurnal Kedokteran Gigi Universitas Padjadjaran Jurnal Ilmiah PANNMED (Pharmacist, Analyst, Nurse, Nutrition, Midwivery, Environment, Dentist)
Minasari Minasari
Departemen Biologi Oral Fakultas Kedokteran Gigi Universitas Sumatera Utara
Dentistry Health Professions Medicine & Pharmacology Nursing Public Health

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EFEK FUNGISTATIS, FUNGISIDAL EKSTRAK KAYU MANIS TERHADAP CANDIDA ALBICANS DAN EFEK BAKTERISTATIS BAKTERISIDAL TERHADAP STAPHYLOCOCCUS AUREUS DARI DENTURE STOMATITIS Minasari Minasari; Dennis Dominika
Jurnal Ilmiah PANNMED (Pharmacist, Analyst, Nurse, Nutrition, Midwivery, Environment, Dentist) Vol. 12 No. 1 (2017): Jurnal Ilmiah PANNMED Periode Mei - Agustus 2017
Publisher : Poltekkes Kemenkes Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (360.383 KB) | DOI: 10.36911/pannmed.v12i1.40

Abstract

Cinnamon is one of the spices that has been used for a long time, even before 2100 BC as an essential material to mummify a king's body and also as addition for foods and drinks to increase the flavours. Cinnamon has three active components such as cinnamaldehyd, eugenol and linalool. Cinnamon has good fungicidal and fungistatic effect against Candida albicans and bacteristatic, bactericidal effect against Staphylococcus aureus. Cinnamon can be used to decrease the amount of Candida albicans and Staphylococcus aureus colonies, so the researcher is interested to examine the fungistatic, fungicidal, bacteristatic dan bactericidal effect against Candida albicans and Staphylococcus aureus. The goal of this research is to determine the effect of different concentrations of cinnamon extract against Candida albicans and Staphylococcus aureus.In this research, the extract's concentrations that are used are 100%, 50%, 25%, 12,5%, 6,25%, 3,125%, 1,56%, 0,78%, 0,39%, 0,195% and also two controls which are formaldehyd and aquadest. The extract used in this research is obtained by extraction method. Dilution technique is used in the test with three times replication. This research is experimental laboratorium type with pretest-postest design. Kruskal-Wallis and Mann-Whitney test is used to analyze the data.The result show that concentration 0,78 % extract has shown fungistatic effect and concentration 25% has shown fungicidal effect against Candida albicans, and concentration 1,562% bacteristatic, concentration 50% bactericidal Staphylococcus aureus. From double comparison table, we can conclude that there are significant difference between each concentration's effect against Candida albicans and Staphylococcus aureus.The result shows that the increase of cinnamon extract's concentration will lessen the remaining colonies of Candida albicans.
Efektivitas ekstrak kulit kayu rambutan (Nephelium lappaceum L.) terhadap Candida albicansThe effectiveness of rambutan (Nephelium lappaceum L.) bark extract on the growth of Candida albicans Minasari Nasution; Sri Amelia; Masdelina Nasution
Jurnal Kedokteran Gigi Universitas Padjadjaran Vol 33, No 2 (2021): Agustus 2021
Publisher : Fakultas Kedokteran Gigi Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/jkg.v33i2.32223

Abstract

Pendahuluan: Ekstrak kulit kayu rambutan memiliki senyawa aktif yang digunakan sebagai  antijamur terutama pada Candida albicans. Candida albicans pada rongga mulut dapat menyebabkan kandidiasis lidah. Salah satu faktor predisposisi yang memicu kandidiasis adalah terganggunya ekologi mulut atau perubahan mikrobiologi mulut karena pemakaian antibiotika dalam waktu yang lama oleh karena itu diperlukan antibiotik berbahan herbal yang dapat digunakan secara topikal. Tujuan penelitian ini untuk mengetahui efektivitas daya hambat ekstrak kulit kayu rambutan terhadap pertumbuhan Candida albicans pada konsentrasi 80%, 40%, 20%,10%, konsentrasi minimum daya hambat (KHM) dan daya bunuh (KBM) ekstrak kulit kayu rambutan terhadap Candida albicans. Metode: Penelitian ini merupakan eksperimental laboratoris dengan rancangan penelitian post test only control group design. Sampel yang digunakan adalah Candida albicans yang diisolasi dari penderita kandidiasis lidah dan dibiakkan di Laboratorium Mikrobiologi RS USU. Pengujian efektivitas ekstrak kulit kayu rambutan terhadap pertumbuhan Candida albicans dengan metode dilusi dan difusi, ekstrak kulit kayu rambutan dibuat dengan teknik maserasi menggunakan pelarut etanol 70% dengan berbagai konsentrasi (80%, 40%, 20% dan 10%). Hasil: uji Kruskal- Wallis menunjukkan perbedaan zona hambat yang signifikan pada beberapa konsentrasi. KHM Ekstrak kulit kayu rambutan diperoleh 20%, dan KBM 40%. Simpulan: bahwa ekstrak kulit kayu rambutan memiliki efektivitas antijamur terhadap Candida albicans.Kata kunci: kulit kayu rambutan, KHM, KBM, Zona hambat, Candida albicans.
Co-Authors Dennis Dominika Masdelina Nasution Sri Amelia