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Shintia Christina
Universitas Kristen Krida Wacana
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health

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Prevalensi Tumor Payudara di RS Hermina Daan Mogot pada Tahun 2017-2021 Febrina Githa Agatha; Shintia Christina; Purnamawati Purnamawati
Jurnal MedScientiae Vol. 2 No. 1 (2023): April
Publisher : Fakultas Kedokteran dan Ilmu Kesehatan Ukrida

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Abstract

Breast cancer is the number one cause of death in developing countries. The purpose of this study was to determine the prevalence and characteristics of breast tumor patients based on histopathological examination at Hermina Daan Mogot Hospital in 2017-2021. This research is an observational descriptive cross-sectional technique regarding breast tumors with parameters such as age, clinical diagnosis and histopathological diagnosis.. In this study, 716 subjects met the inclusion and exclusion criteria. histopathological diagnosis with the most results of mammary carcinoma at the age of 40-49 (40.86%) and the most histopathological diagnosis of fibroadenoma mammary at the age of 20-29 (37.35%). The most common clinical diagnosis consistent with the histopathological diagnosis is fibroadenoma mammary, which is part of a fibroepithelial tumor. The least common clinical diagnosis was papilloma (0.4%) and the least clinical diagnosis was papillary lesion (0.3%), where the papilloma was part of the papillary lesion. Early breast examination is needed to be able to detect malignant lesions at an early stage so that appropriate management can be carried out immediately so as to increase the patient's life expectancy.
Kemiripan Sekuen Mouse Mammary Tumor Virus dengan Human Mammary Tumor Virus pada Kanker Payudara Shintia Christina; Puspita Eka Wuyung
Jurnal Kedokteran Meditek Vol. 17 No. 45 September - Desember 2011
Publisher : Fakultas Kedokteran Universitas Kristen Krida Wacana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36452/jkdoktmeditek.v17i45.892

Abstract

Abstrackhuman breast cancer incidence varied around the world, where the incidence in Asia is lower than western. Different types if mice in both parts of the world suggestive associated with the incidence of human breast cancer, in which M.domesticus the main carrier of virus more widely available in western. Mouse Mammary Tumor Virus (MMTV) is a type B retrovirus that causes breast cancer in mice. MMTV has a genome consisting of longterminal Repeat (LTR), Pol, Gag, Pro, and Env. MMTV has the ability to tumorigenesis by insertion mutagenesis and may affect genes that are close to the insertion. Transmission of this virus occurs through two channels, namely endogenous and exogenous. Endogenous pathways through the germline, while the exogenous pathway the milk. Several studies have shown the existence of sequence similarity in Env and MMTV LTR by human breast cancer, so that suspected a link between MMTV in human breast cancer. The presence of MMTV in the rate of progression of disease was also found in line, where the higher the degree of malignancy of a tumor also increased the number of MMTV sequences. However, until now we do not know how the MMTV can infect humans, so its role as a cause of human breast cancer is uncertain.Key words : MMTV, breast cancer
Hubungan Antara Gleason Score dengan Kadar PSA Pada Penderita Karsinoma Prostat di RS X Jakarta Barat Reni Angeline; Felicia Mardono; Shintia Christina; Freciyana Boedijono4
Jurnal Ners Vol. 10 No. 4 (2026)
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jn.v10i4.62337

Abstract

Karsinoma prostat merupakan salah satu keganasan dengan insidensi tertinggi pada laki-laki dan masih menjadi penyebab utama morbiditas serta mortalitas yang bermakna, khususnya pada kelompok usia lanjut. Pemeriksaan Prostate-Specific Antigen (PSA) dan penilaian Gleason score pada spesimen Transurethral Resection of Prostate (TURP) dan biopsi prostat merupakan komponen penting dalam evaluasi karsinoma prostat. Tujuan penelitian ini adalah menganalisis hubungan antara Gleason score dengan kadar PSA pada penderita karsinoma prostat di RS X Jakarta Barat. Metode penelitian ini merupakan studi observasional analitik dengan desain potong lintang (cross-sectional) menggunakan data sekunder dari arsip laboratorium patologi anatomi. Sampel terdiri atas pasien karsinoma prostat yang memiliki data kadar PSA dan hasil histopatologi dari TURP dan biopsi prostat. Analisis hubungan dilakukan dengan uji korelasi Spearman. Hasil dari 64 pasien yang memenuhi kriteria penelitian, sebagian besar berusia 71–80 tahun (40,6%). Adenokarsinoma asinar merupakan tipe histopatologi tersering (90,6%). Sebagian besar pasien termasuk kelompok risiko tinggi berdasarkan Gleason score (73,4%) dan memiliki kadar PSA tinggi (>10 ng/mL) (85,9%). Uji korelasi Spearman menunjukkan rho = -0,126 dengan p = 0,322, sehingga tidak terdapat hubungan yang bermakna secara statistik antara Gleason score dengan kadar PSA. Simpulan pada penelitian ini, peningkatan Gleason score tidak menunjukkan hubungan yang bermakna dengan peningkatan kadar PSA sehingga kadar PSA tidak dapat digunakan sebagai indikator tunggal untuk memprediksi agresivitas tumor. Oleh karena itu, interpretasi kadar PSA perlu dipadukan dengan parameter klinis, histopatologis dan radiologis lainnya.
Co-Authors Febrina Githa Agatha Felicia Mardono Freciyana Boedijono4 Purnamawati Purnamawati Puspita Eka Wuyung Reni Angeline