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All Journal Jurnal Ners Jurnal Kedokteran Meditek Borneo Journal of Pharmacy
Hendrik Kurniawan
UNIVERSITAS KRISTEN KRIDA WACANA
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health

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Hubungan Status Gizi dengan Kejadian Infeksi Saluran Pernapasan Akut pada Balita di Puskesmas Kecamatan Kebon Jeruk Bulan Agustus 2016 Pamela Felita; Hendrik Kurniawan; Anna Maria Dewajanti
Jurnal Kedokteran Meditek VOL. 24 NO. 65 JANUARI-MARET 2018
Publisher : Fakultas Kedokteran Universitas Kristen Krida Wacana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36452/jkdoktmeditek.v24i65.1655

Abstract

Acute Respiratory Infection (ARI) is one of the main causes of patients to visit health facilities. The incidence and prevalence of ARI in Indonesia in 2013 is 1.8 and 4.5%, respectively. ARI is still among the top ranks of eleven major causes of morbidity and mortality in children under five in 2013. One of the factors that makes a person get exposed to respiratory diseases is the nutritional status. This study aimed to determine whether there is a relationship between nutritional status and the incidence of ARI in infants at Puskesmas Kecamatan Kebon Jeruk on August 2016. Research subjects were toddlers who sought treatment at MTBS (Manajemen Terpadu Balita Sakit) health center in Puskesmas Kecamatan Kebon Jeruk. Eighty-four subjects participated in this study were selected by a consecutive sampling technique. Nutritional status was categorized based on anthropometric standards by measuring body weight age ratio. Among the subjects, 9 infants (64,3%) had bad nutrition and ISPA, whereas 49 infants (70,0%) had good nutrition and ISPA. Statistical analysis using Fisher test obtained a significance value, with a p-value of 0.754 (p> 0.05). The study concludes that there was no association between nutritional status and the incidence of ARI in infants in Puskesmas Kecamatan Kebon Jeruk in August 2016.Keywords: respiratory infections, nutritional status, toddler, Puskesmas Kecamatan Kebon Jeruk
Antioxidant, Antidiabetic, and Anti-obesity Potential of Ipomoea reptans Poir Leaves Hendrik Kurniawan; Ermenilda Sonia Dacamis; Adelina Simamora; Priscilla Sari Dianauli Lumban Tobing; Ali Hanapiah; Adit Widodo Santoso
Borneo Journal of Pharmacy Vol. 3 No. 4 (2020): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v3i4.1583

Abstract

Ipomoea reptans Poir or kangkung is a popular leafy vegetable, a favorite to people in Asian countries. However, limited information is available on their bioactivities. In the present study, the antioxidant, antidiabetic, and anti-obesity potential of I. reptans leaves were investigated. Different fractions (ethanol, ethyl acetate, and hexane) of I. reptans leaves were evaluated for their scavenging activity on DPPH radicals, whereas their reducing potential was investigated by cupric reducing antioxidant capacity (CuPRAC), total antioxidant, and reducing power assays. The antidiabetic potential was investigated by their inhibition effect on α-glucosidase. Total phenolic and flavonoid contents of I. reptans leaves were solvent dependent. Ethyl acetate contained the highest phenolic content, followed by ethanol and hexane fractions. However, for flavonoid content, the order was ethanol > ethyl acetate > hexane. All fractions showed DPPH scavenging activity in a concentration-dependent manner, with activities weaker than standards ascorbic acid and BHT, in the order of ethanol > ethyl acetate > hexane. All fractions showed reducing capacity, but only hexane and ethanol fractions of I. reptans leaves showed inhibition on α-glucosidase, with hexane showed more potent inhibition compared to acarbose. The study also found that fractions of I. reptans inhibit lipase and trypsin, enzymes related to lipid metabolism. Findings in this study offer a prospect for I. reptans leaves as a functional food source for antioxidant, antidiabetic, and anti-obesity purposes.
Uji In Vivo Aktifitas Antihiperurisemia Ekstrak Etanol Bunga Melinjo (Gnetum Gnemon L.) Anna Maria Dewajanti; Agus Limanto; Bella N. Wijaya; Erma Mexcorry Sumbayak; Hendrik Kurniawan
Jurnal Ners Vol. 10 No. 2 (2026)
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jn.v10i2.55409

Abstract

Hiperurisemia merupakan keadaan di mana kadar asam urat di dalam darah tinggi sehingga dapat menimbulkan penyakit gout, kerusakan ginjal, dan komplikasi lain. Dalam beberapa dekade terakhir, peneliti mulai mengembangkan tanaman obat untuk menyembuhkan beberapa penyakit, salah satunya adalah tanaman melinjo. Penelitian ini bertujuan untuk mengevaluasi aktivitas antihiperurisemia ekstrak bunga melinjo (Gnetum gnemon L). Desain penelitian eksperimental ini pre-post test control group. Aktivitas antihiperurisemia dinilai melalui pengukuran kadar asam urat plasma darah tikus putih Sprague Dawley yang diinduksi hiperurisemia. Kelompok perlakuan menerima ekstrak dengan dosis 450 mg/kgBB dan 900 mg/kgBB, yang dibandingkan dengan kelompok kontrol positif (allopurinol 90 mg/kgBB) dan negatif (Na- CMC 0,5%). Pemberian ekstrak dosis 450 mg/kgBB dan 900 mg/kgBB secara signifikan menurunkan kadar asam urat darah, dengan nilai p < 0,05 (Uji Wilcoxon), begitu pula dengan allopurinol. Pada analisis antar kelompok, kadar asam urat hari ke-7 berbeda bermakna (uji Kruskal–Wallis), dengan perbedaan terutama antara kontrol negatif dan kelompok perlakuan/kontrol positif (post-hoc Bonferroni). Tidak terdapat perbedaan bermakna antara kontrol positif dan kelompok ekstrak pada hari ke-7. Hasil penelitian ini membuktikan potensi ekstrak bunga melinjo sebagai agen alami dan berperan dalam pengelolaan antihiperurisemia. Temuan ini mendukung pengembangan terapi alternatif berbasis bahan alami dengan risiko efek samping yang lebih rendah
Co-Authors Adit Widodo Santoso Agus Limanto Ali Hanapiah Anna Maria Dewajanti Bella N. Wijaya Erma Mexcorry Sumbayak Ermenilda Sonia Dacamis Pamela Felita Priscilla Sari Dianauli Lumban Tobing Simamora, Adelina