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Audrey Desiree
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Biochemistry, Genetics & Molecular Biology Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

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Efektivitas Immunoterapi Dalam Tatalaksana Guillain-Barré Syndrome Pada Anak Giovanni Reynaldo; Audrey Desiree
Jurnal Kedokteran Meditek Vol 25 No 3 (2019): SEPTEMBER - DESEMBER
Publisher : Fakultas Kedokteran Universitas Kristen Krida Wacana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36452/jkdoktmeditek.v25i3.1783

Abstract

Guillain-Barré Syndrome (GBS) is an immune-mediated inflammatory disorder of the peripheral nervous system in which an autoimmune response is directed against peripheral nerves. The pathogenesis of GBS is believed to be an abnormal immune response to an antecedent event, most commonly an infection, and in a few cases associated with vaccination especially in children. The clinical manifestation of GBS is rapid and ascending progressive bilateral limb weakness. Therapies which are still being used and considered effective are intravenous immunoglobulin and plasmapheresis. New modalities such as Interferon-β (IFN-β), Cyclophosphamide, and Human Monoclonal Antibody still require further study related to the effectiveness and potential side effects. The prognosis of GBS in children is much better, the mortality rate is also very low, affecting 1-2% of children with GBS, while only 4% of paediatric patients are in need of respiratory support during hospitalisation.
Co-Authors Giovanni Reynaldo