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Diagnosis dan Penatalaksanaan Karsinoma Tonsil Benny Kurnia; Lily Setiani; Juniar Juniar; Safarianti Safarianti
Jurnal Kedokteran Syiah Kuala Vol 21, No 2 (2021): Volume 21 Nomor 2 Agustus 2021
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24815/jks.v21i2.20360

AbstractTonsilar carcinoma is the most common squamous cell carcinoma of the tonsils that presents as ulcerated lesions on a necrotic basis. These tumors often appear at an advanced stage and often metastasize to the lymph nodes. In recent years, head and neck malignancies due to HPV infection have increased. Other causes of carcinoma of the tonsils are smoking and alcohol abuse. The overall incidence of tonsillar carcinoma increase in the younger population, and this may be associated with an increase of human papilloma virus infection. Tonsil carcinoma varies in clinical history. In the early stages, tonsilar carcinoma are asymptomatic, but at an advanced stages patients might have complaint of a persistent sore throat, unilateral otalgia, or a sensation of mass in the throat, bleeding from the mouth, fetor oris with trismus as a sign of a local invasion. The diagnosis of tonsilar carcinoma made based on history, physical examination, clinical symptoms, and supporting examinations such as of CT scan, MRI and tumor tissue biopsy. Management of tonsilar carcinoma for stage I-II and stage III (T1-2, N1) are local and regional radiotherapy to achieve a good effect. Radiotherapy is the main treatment modality in early-stage of tonsillar carcinoma. concomitant chemotherapy and radiation therapy are the standard treatment for advanced tonsillar carcinoma currently. chemotherapy can be given before radiotherapy or as neoadjuvant, given after radiotherapy or as adjuvant, or given concurrently with radiotherapy.

Characteristics of mastoid carcinoma patients in Otorhinolaryngology-HNS Department Zainoel Abidin General Hospital Banda Aceh Benny - Kurnia; Baluqia Iskandar Putri
Oto Rhino Laryngologica Indonesiana Vol 51, No 1 (2021): Volume 51, No. 1 January - June 2021
Publisher : PERHATI-KL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32637/orli.v51i1.419

Background: Mastoid carcinoma is a rare case of an aggressive tumor with a poor prognosis. Purpose: To identify the characteristics of mastoid carcinoma patients in Otorhinolaryngology Head and Neck Surgery Department of dr. Zainoel Abidin General Hospital, Banda Aceh. Method: This was a descriptive study using medical records data from January 2012 to July 2019, and from the histopathological data as a confirmation. Result: There were 9 cases consisted of 4 male and 5 female patients with the ratio 1:1.2, between the age of 12-72 years old, and the majority was in 41-60 years group of age. Clinical symptoms obtained are otalgia (100%), otorrhea (100%),facial paresis (100%), hearing loss (100%), ear canal mass (100%) and retroauricular mass (44.4%). The histopathological type of all cases was squamous cell carcinoma (100%). Based on CT scan examination results, there were 55.6% cases in stage IV and 44.4% in stage III. Chemotherapy was given to 89% of patients, and 11% received radiotherapy. Conclusion: Mastoid carcinoma is a rare case. In our study, there were 4 male and 5 female patients with mastoid carcinoma. The histopathological type of all patients was squamous cell carcinoma, in stage III and IV. Chemotherapy was given to 9 patients, and 1 patient received radiotherapy.ABSTRAKLatar belakang: Karsinoma mastoid merupakan kasus yang jarang namun serta bersifat agresif dan memiliki prognosis buruk. Tujuan: Mengetahui karakteristik pasien karsinoma mastoid di Bagian Telinga Hidung Tenggorok Bedah Kepala Leher, Rumah Sakit Umum Daerah dr. Zainoel Abidin Banda Aceh. Metode: Penelitian deskriptif dengan menggunakan data rekam medik RSUD dr. Zainoel Abidin Banda Aceh periode Januari 2012 sampai Juli 2019 dan data hasil pemeriksaan histopatologi sebagai konfirmasi. Hasil: Didapatkan 9 kasus terdiri dari 4 pria dan 5 wanita dengan perbandingan 1:1,2. Sebaran usia pasien dari 12 sampai 72 tahun dengan insiden puncak usia 41-60 tahun. Gejala klinis yang didapatkan adalah otalgia (100%), sekret telinga (100%), paresis fasialis (100%), penurunan pendengaran (100%), massa di liang telinga (100%) dan massa retroaurikular (44,4%). Tipe histopatologi seluruh kasus adalah Squamous Cell Carcinoma (100%). Stadium IV sebesar 55,6% dan stadium III sebesar 44,4% ditentukan berdasarkan CT Scan. Dilakukan kemoterapi pada 89% pasien dan radioterapi pada 11% pasien. Kesimpulan: Karsinoma mastoid merupakan kasus yang jarang. Pada penelitian kami didapati 4 pasien laki-laki dan 5 pasien perempuan penderita karsinoma mastoid dengan usia terbanyak pada 41-60 tahun. Histopatologi seluruh pasien merupakan karsinoma sel skuamosa stadium III dan stadium IV. Kemoterapi diberikan kepada 9 pasien, dan 1 pasien mendapat radioterapi.Kata kunci: karsinoma mastoid, karakteristik, gejala klinis, histopatologi, terapi

Characteristics of non-Hodgkin lymphoma patients in Otorhinolaryngology-HNS Department Zainoel Abidin General Hospital Banda Aceh Fadhlia Fadhlia; Benny Kurnia; Lily Setiani; Yerni Karnita; Juniar Juniar; Iip Berliananda
Oto Rhino Laryngologica Indonesiana Vol 50, No 1 (2020): Volume 50, No. 1 January - June 2020
Publisher : PERHATI-KL

Background: Non-Hodgkin’s lymphoma (NHL) is a primary malignancy in the lymphatic system and extranodal lymphoid tissue originating from B lymphocyte cells, T lymphocytes or natural killer (NK) cells. The incidence of NHL continues to increase with various characteristics. Objective: To find out the characteristics of NHL sufferers undergoing treatment in Otorhinolaryngology Head and Neck Surgery Department of dr. Zainoel Abidin Regional General Hospital (RSUDZA), Banda Aceh from January 2015 to December 2018. Method: This was an observational descriptive study conducted at Banda Aceh RSUDZA using retrospective secondary data collection from medical records that met the inclusion criteria, in total sampling method. Result: Found 32 research subjects, dominantly male (20), the highest age range was 56-65 years (10). The main complaints were neck lumps (10) and oropharynx lumps (11). The most common NHL was from B lymphocyte cells (6). The chemotherapy regimens used are cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP) and rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP). The most frequent side effects are anemia, hypoalbuminemia, and leukopenia. Conclusion: The results showed that NHL was most common in men with an increased incidence in the fifth decade. Neck lumps are the most common complaint. The chemotherapy regimen used is CHOP and R-CHOP.Keywords : Non-Hodgkin’s Lymphoma, chemotherapy ABSTRAK Latar belakang: Limfoma Non-Hodgkin (LNH) adalah keganasan primer pada sistem limfatik dan jaringan limfoid ekstranodal yang berasal dari sel limfosit B, limfosit T atau sel natural killer (NK). Kejadian LNH terus meningkat dengan berbagai karakteristik. Tujuan: Melihat karakteristik penderita LNH yang menjalani pengobatan di Departemen THT-KL RSUD dr. Zainoel Abidin (RSUDZA), Banda Aceh pada periode Januari 2015 sampai Desember 2018. Metode: Penelitian deskriptif observasional dengan pengambilan data sekunder secara retrospektif dari rekam medis yang memenuhi kriteria inklusi, dengan metode total sampling. Hasil: Didapatkan total subjek penelitian 32 orang, dominan pada lakilaki (20), rentang usia tertinggi antara 56-65 tahun (10). Keluhan utama terbanyak adalah benjolan di leher (10) dan benjolan orofaring (11). LNH yang berasal dari sel limfosit B paling banyak dijumpai (6). Regimen kemoterapi yang digunakan adalah cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP) dan rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP). Efek samping paling sering adalah anemia, hipoalbuminemia dan leukopenia. Kesimpulan: Hasil penelitian menunjukkan LNH paling sering pada laki-laki dengan angka kejadian meningkat pada dekade kelima. Keluhan yang paling sering adalah benjolan di leher. Regimen kemoterapi yang digunakan adalah CHOP dan R-CHOP.

CHARACTERISTIC OF NASOPHARYNGEAL CARSINOMA IN ACEH 2016-2017 Benny Kurnia; Reno Keumalazia Kamarlis; Fera Kamila Kamal
INTERNATIONAL JOURNAL OF NASOPHARYNGEAL CARCINOMA Vol. 1 No. 01 (2019): International Journal of Nasopharyngeal Carcinoma
Publisher : TALENTA PUBLISHER

Introduction Nasopharyngeal carcinoma is among five major malignancies in Indonesia and the primary malignant tumor in men. Among all head and neck (H&N) cancers, nasopharyngeal carcinoma (NPC) is endemic in certain regions of the world, especially in Southeast Asia, and has a poor prognosis. In Indonesia, the recorded mean prevalence is 13 000 yearly new NPC cases, but otherwise little is documented on NPC in Indonesia. Objectives We collected all cases of nasopharyngeal carcinoma diagnosed by histopathological examination during the period of 2016-2017 from archives of the registry in the Ear, Nose, and Throat department and Patologi Anatomy laboratory Dr. Zainoel Abidin General Hospital. We did this research to presenting the basic data of NPC in Aceh according to gender, age, geographic site and WHO histopathology criteria. Method All the data we counted by using Microsoft Excel 2016 by grouping it according to the variable that we want to grade. We made it into a table and graphic presentation to explain each item of the variable. Result Here, in Aceh, we reported 46 cases in the year 2016 and 26 cases in the year 2017, a total of 72 patients during 2 years. We studied NPC incidence in Aceh among all H&N cancer cases focusing on age, gender, the ethnic background, and the disease histopathology. In this study population, from a total of 72 patient we found 44 male (61.1%) and 28 female (38.9%), with a male to female ratio is 1.57:1. According to the geographic site, NPC in Aceh was the most endemic in the Banda Aceh population (15.3%) followed by Southwest Aceh (12.5%) as a second one. From the age range, NPC most frequent to affect patients at the age range 41-60 years (44.44%), besides that we found 8 (11.11%) cases NPC in Aceh at the age 0- 20 years with 13 years old patient was the younger one. Here, we found that Undifferentiated NPC is the most frequent histological type (44.4%). We continued the study by analyzed NPC patient according to WHO criteria, type I WHO most frequent from the Great Aceh. Type II and Type III WHO we found most frequent from Banda Aceh. Conclusion: Our data NPC incidence did not differ significantly among the literature. Mostly NPC patients over the world at the old adult age, even all of the age range can be affected by NPC. There are similar histopathological features results here compare to the Southeast Asian country.

Analysis Titer of Epidermal Growth Factor Receptor on Nasopharyngeal Cancer Patients Based on Stadium and Histopathological Profile in Dr. Zainoel Abidin General Hospital Banda Aceh Benny Kurnia; Fera Kamila Kemal; Basri Abdul Gani
INTERNATIONAL JOURNAL OF NASOPHARYNGEAL CARCINOMA Vol. 3 No. 01 (2021): International Journal of Nasopharyngeal Carcinoma
Publisher : TALENTA PUBLISHER

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/ijnpc.v3i01.5723

Introduction: Nasopharyngeal carcinoma ranks first in incidence at the head and the neck departement. Epidermal Growth Factor Receptor (EGFR) is a transmembrane tyrosine kinase receptor from the ErbB family. Excess EGFR titer is an indication of a malignant transformation and cell differentiation that can ultimately determine the effectiveness of using anti EGFR drugs nasopharyngeal carcinoma patients. Objective: To determine the EGFR titer of nasopharyngeal cancer tissue based on the stage and histopathological profile in Dr. Zainoel Abidin Banda Aceh. Methods: Patients with suspected nasopharyngeal carcinoma were subjected to a nasopharyngeal biopsy examination, some samples were sent to the Anatomical Pathology Laboratory of the General Hospital Dr. Zainoel Abidin Banda Aceh for histopathological examination and some were sent to the Research Laboratory of the Faculty of Dentistry, Syiah Kuala University for examination of EGFR titers. This study was conducted from January 2020 to October 2020. Results: There were 17 samples of nasopharyngeal carcinoma. Based on the results of the Paired T test analysis, it can be seen that there is a difference in the quantity of EGFR titers of each study subject with the variable stage and histopathological profile. Specifically, the Paired T test analysis between EGFR titers and Stadium (P<0.05; 0.00); and analysis of EGFR titer with histopathological profile (P<0.05; 0.00). In general, the Friedmann test analysis showed that there were significant differences in the incidence of nasopharyngeal carcinoma in patients with regard to age, histopathological profile and stage (P<0.05). Conclusion: EGFR titer quantity has a positive relationship with nasopharyngeal carcinoma stage and there is no relationship between EGFR titer and histopathological profile of nasopharyngeal carcinoma

Young Woman with Early Stage Nasopharyngeal Carcinoma: A Rare Case Benny Kurnia; Fadhlia; Lily Setiani; Juniar; Ridha Chaharsyah Mulya
INTERNATIONAL JOURNAL OF NASOPHARYNGEAL CARCINOMA Vol. 3 No. 01 (2021): International Journal of Nasopharyngeal Carcinoma
Publisher : TALENTA PUBLISHER

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/ijnpc.v3i01.5728

Introduction: Nasopharyngeal carcinoma (NPC) is the most often cancer occurs in the head and neck. Early stage NPC is difficult to diagnose clinically, most NPC patients have been diagnosed in advanced stages. The study presents a case of early-stage NPC with the symptoms of recurrent nosebleeds and headache which can be early symptom to suspect NPC. Case report: We reported a case of 27-year-old woman patient with chief complaints recurrent nosebleeds since 2 months ago frequently one to two times a week. Patients also complained of mild headaches, but getting better by taking a rest and patient also had a history of tinnitus since 2 month ago. The patient has a habit of consuming salted fish and preservative food since childhood. Based on his history of illness, physical examination, imaging, and histopathology, we concluded that he was diagnosed with Nasopharyngeal Carcinoma T1N0M0, and the patient are going to reffered to North Sumatera or central java to get radiotherapy. Conclusion: Early stage of nasopharyngeal cancer is a rare condition at Aceh, the fastest we found early stages will increased survival rate.

Characteristics of non-Hodgkin lymphoma patients in Otorhinolaryngology-HNS Department Zainoel Abidin General Hospital Banda Aceh Fadhlia Fadhlia; Benny Kurnia; Lily Setiani; Yerni Karnita; Juniar Juniar; Iip Berliananda
Oto Rhino Laryngologica Indonesiana Vol. 50 No. 1 (2020): Volume 50, No. 1 January - June 2020
Publisher : PERHATI-KL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32637/orli.v50i1.352

Background: Non-Hodgkin’s lymphoma (NHL) is a primary malignancy in the lymphatic system and extranodal lymphoid tissue originating from B lymphocyte cells, T lymphocytes or natural killer (NK) cells. The incidence of NHL continues to increase with various characteristics. Objective: To find out the characteristics of NHL sufferers undergoing treatment in Otorhinolaryngology Head and Neck Surgery Department of dr. Zainoel Abidin Regional General Hospital (RSUDZA), Banda Aceh from January 2015 to December 2018. Method: This was an observational descriptive study conducted at Banda Aceh RSUDZA using retrospective secondary data collection from medical records that met the inclusion criteria, in total sampling method. Result: Found 32 research subjects, dominantly male (20), the highest age range was 56-65 years (10). The main complaints were neck lumps (10) and oropharynx lumps (11). The most common NHL was from B lymphocyte cells (6). The chemotherapy regimens used are cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP) and rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP). The most frequent side effects are anemia, hypoalbuminemia, and leukopenia. Conclusion: The results showed that NHL was most common in men with an increased incidence in the fifth decade. Neck lumps are the most common complaint. The chemotherapy regimen used is CHOP and R-CHOP.Keywords : Non-Hodgkin’s Lymphoma, chemotherapy ABSTRAK Latar belakang: Limfoma Non-Hodgkin (LNH) adalah keganasan primer pada sistem limfatik dan jaringan limfoid ekstranodal yang berasal dari sel limfosit B, limfosit T atau sel natural killer (NK). Kejadian LNH terus meningkat dengan berbagai karakteristik. Tujuan: Melihat karakteristik penderita LNH yang menjalani pengobatan di Departemen THT-KL RSUD dr. Zainoel Abidin (RSUDZA), Banda Aceh pada periode Januari 2015 sampai Desember 2018. Metode: Penelitian deskriptif observasional dengan pengambilan data sekunder secara retrospektif dari rekam medis yang memenuhi kriteria inklusi, dengan metode total sampling. Hasil: Didapatkan total subjek penelitian 32 orang, dominan pada lakilaki (20), rentang usia tertinggi antara 56-65 tahun (10). Keluhan utama terbanyak adalah benjolan di leher (10) dan benjolan orofaring (11). LNH yang berasal dari sel limfosit B paling banyak dijumpai (6). Regimen kemoterapi yang digunakan adalah cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP) dan rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP). Efek samping paling sering adalah anemia, hipoalbuminemia dan leukopenia. Kesimpulan: Hasil penelitian menunjukkan LNH paling sering pada laki-laki dengan angka kejadian meningkat pada dekade kelima. Keluhan yang paling sering adalah benjolan di leher. Regimen kemoterapi yang digunakan adalah CHOP dan R-CHOP.

Characteristics of mastoid carcinoma patients in Otorhinolaryngology-HNS Department Zainoel Abidin General Hospital Banda Aceh Benny - Kurnia; Baluqia Iskandar Putri
Oto Rhino Laryngologica Indonesiana Vol. 51 No. 1 (2021): Volume 51, No. 1 January - June 2021
Publisher : PERHATI-KL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32637/orli.v51i1.419

Background: Mastoid carcinoma is a rare case of an aggressive tumor with a poor prognosis. Purpose: To identify the characteristics of mastoid carcinoma patients in Otorhinolaryngology Head and Neck Surgery Department of dr. Zainoel Abidin General Hospital, Banda Aceh. Method: This was a descriptive study using medical records data from January 2012 to July 2019, and from the histopathological data as a confirmation. Result: There were 9 cases consisted of 4 male and 5 female patients with the ratio 1:1.2, between the age of 12-72 years old, and the majority was in 41-60 years group of age. Clinical symptoms obtained are otalgia (100%), otorrhea (100%),facial paresis (100%), hearing loss (100%), ear canal mass (100%) and retroauricular mass (44.4%). The histopathological type of all cases was squamous cell carcinoma (100%). Based on CT scan examination results, there were 55.6% cases in stage IV and 44.4% in stage III. Chemotherapy was given to 89% of patients, and 11% received radiotherapy. Conclusion: Mastoid carcinoma is a rare case. In our study, there were 4 male and 5 female patients with mastoid carcinoma. The histopathological type of all patients was squamous cell carcinoma, in stage III and IV. Chemotherapy was given to 9 patients, and 1 patient received radiotherapy.ABSTRAKLatar belakang: Karsinoma mastoid merupakan kasus yang jarang namun serta bersifat agresif dan memiliki prognosis buruk. Tujuan: Mengetahui karakteristik pasien karsinoma mastoid di Bagian Telinga Hidung Tenggorok Bedah Kepala Leher, Rumah Sakit Umum Daerah dr. Zainoel Abidin Banda Aceh. Metode: Penelitian deskriptif dengan menggunakan data rekam medik RSUD dr. Zainoel Abidin Banda Aceh periode Januari 2012 sampai Juli 2019 dan data hasil pemeriksaan histopatologi sebagai konfirmasi. Hasil: Didapatkan 9 kasus terdiri dari 4 pria dan 5 wanita dengan perbandingan 1:1,2. Sebaran usia pasien dari 12 sampai 72 tahun dengan insiden puncak usia 41-60 tahun. Gejala klinis yang didapatkan adalah otalgia (100%), sekret telinga (100%), paresis fasialis (100%), penurunan pendengaran (100%), massa di liang telinga (100%) dan massa retroaurikular (44,4%). Tipe histopatologi seluruh kasus adalah Squamous Cell Carcinoma (100%). Stadium IV sebesar 55,6% dan stadium III sebesar 44,4% ditentukan berdasarkan CT Scan. Dilakukan kemoterapi pada 89% pasien dan radioterapi pada 11% pasien. Kesimpulan: Karsinoma mastoid merupakan kasus yang jarang. Pada penelitian kami didapati 4 pasien laki-laki dan 5 pasien perempuan penderita karsinoma mastoid dengan usia terbanyak pada 41-60 tahun. Histopatologi seluruh pasien merupakan karsinoma sel skuamosa stadium III dan stadium IV. Kemoterapi diberikan kepada 9 pasien, dan 1 pasien mendapat radioterapi.Kata kunci: karsinoma mastoid, karakteristik, gejala klinis, histopatologi, terapi

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