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Gambaran tingkat kepatuhan penggunaan obat antihipertensi pada penderita hipertensi di puskesmas pante raya kabupaten Bener Meriah periode bulan Agustus 2020 Chesy Oety Otawa; Kartini Hasballah; Reno Keumalazia Kamarlis
Jurnal Kedokteran Syiah Kuala Vol 21, No 3 (2021): Volume 21 Nomor 3 Desember 2021
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24815/jks.v21i3.19821

Hipertensi merupakan keadaan meningkatnya tekanan kapiler darah akibat terjadi konstriksi pada pembuluh darah. Pada penanganan hipertensi perlu menggunakan obat antihipertensi yang akan efektif jika dengan meminumnya sesuai anjuran tenaga kesehatan, Berdasarkan alasan tersebut, peneliti bermaksud untuk mengetahui tingkat kepatuhan penggunaan obat antihipertensi pada penderita hipertensi di Puskesmas Pante Raya periode Bulan Agustus 2020. Penelitian ini menggunakan survei deskriptif observational dengan pendekatan cross sectional. Sampel yang digunakan pada penelitian ini adalah seluruh pasien yang telah didiagnosis hipertensi di Puskesmas Pante Raya Kabupaten Bener Meriah yang memenuhi kriteria pada periode Agustus 2020 dan diambil dengan teknik consecutive sampling. Responden berjumlah 49 orang dengan jumlah populasi 62 orang. Instrumen yang digunakan adalah kuesioner Morisky Medication Adherence Scale (MMAS-8). Hasil yang didapatkan pada penelitian ini adalah tingkat kepatuhan penderita hipertensi di Puskesmas Pante Raya periode Agustus rendah, dengan mencapai persentase 100%. Penderita hipertensi banyak diderita oleh usia 56-65 tahun sebanyak (46,9%) dengan jumlah wanita (79,6%) lebih banyak dibandingkan laki-laki (20,4%). pendidikan terakhir responden terbanyak adalah tingkat SMA/sederajat (42,9%) sedangkan responden yang bekerja (65,3%) lebih banyak daripada yang tidak bekerja (65,3%). Maka dapat disimpulkan bahwa tingkat kepatuhan penggunaan obat antihipertensi pada Puskesmas Pante Raya periode bulan Agustus 2020 adalah rendah.

Clear cell sarcoma Reno Keumalazia Kamarlis
Jurnal Kedokteran Syiah Kuala Vol 8, No 1 (2008): Volume 8 Nomor 1 April 2008
Publisher : Universitas Syiah Kuala

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Abstrak. Seorang laki-laki berusia 24 tahun, dengan benjolan pada kaki kiri dan nyeri sejak 1 tahun yang lalu. Dilakukan tindakan operasi, makroskopis tampak benjolan dengan bentuk tidak teratur, ukuran 4 x 3 x 1,5 cm, putih kecoklatan, kenyal. Mikroskopis tampak proliferasi jaringan ikat dengan sel-sel bentuk spindel, inti oval poligonal, kromatin kasar, sitoplasma banyak dan jernih. Kelompokan sl-sel dibatasi oleh jaringan ikat. Pada bagian lain tampak bercak-bercak pigmen. Kesimpulannya suatu clear cell carcinoma (malignant melanoma of soft part) yang merupakan suatu tumor jaringan lunak. (JKS 2008; 1:29-32) Kata kunci : proliferasi jaringan ikat, clear cell carcinoma, tumor jaringan lunak. Abstract. A man, 24 years old age, with swelling in left cruris from 1 year ago. From surgery, in gross examination there was a mass, irregular, 4 x 3 x 1,5 ems in size, white-brownish, elastic. From microscopic examination, there is proliferation of spindels cells, oval - polygonal nuclei, coarse chromatin, clear and amount cytoplasm. The clusters cells separated by fibrous tissue. In the other part, there is pigmented area.The conclusion is clear cell carcinoma (malignant melanoma of soft part), a soft tissue tumor. (JKS 2008; 1:29-32) Keyword: fibrous tissue proliferation, clear cell carcinoma, soft tissue tumor.

Profil Sitologi Efusi Pleura di RSUD Zainoel Abidin Banda Aceh Fitri Dewi Ismida; Budi Yanti; Cut Asmaul Husna; Istanul Badiri; Reno Keumalazia kamarlis
Jurnal Kedokteran Syiah Kuala Vol 21, No 3 (2021): Volume 21 Nomor 3 Desember 2021
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24815/jks.v21i3.23805

Efusi pleura merupakan problem diagnosticutama pada kelainanparukarena pleura merupakansuaturongga yang melapisiparutanpaadaaksesapapun. Analisissitologiefusi pleura seringkalidigunakansebagailinipertamapenapisandalampenegakan diagnosis dan tindakanpenatalaksananlebihlanjut. Pemeriksaansitologiefusi pleura sangatpentingkarenadapatmemberikaninformasiinflamasi, keganasan dan metastasis.Penelitianinimenggunakanmetodedeskriptif, mengamatiseluruhbahanefusi pleura yang dilakukananalisissitologiselamaperiodeduatahun dan diperoleh 697 kasusefusi pleura di laboratoriumPatologiAnatomiRumahSakitZainoelAbidin, Banda Aceh. Hasil pemeriksaansitologi 697 bahanefusi pleura ditemukan paling banyakmenunjukkan diagnosis klinistidakdapatdisimpulkan 344 efusi pleura dan diagnosis klinisbukansuatu proses keganasan 294 (total 91,52%), diantaranya paling banyakmenunjukkansuatuperadangankronisdengansebaransellimfosit yang dominanyaitu 124 (41.5%). Dan dari 59 bahanefusi pleura denganjeniskeganasanmenunjukkanbahwa paling banyakditemukan adenocarsinomayaitu 29 (49,1%) dan terdapat 22 (37,3%) bahanefusi pleura denganjeniskeganasan primer yaituSquamousCellCarsinoma. Sitologiefusi pleura merupakanmodalitasdiagnosticmudah dan sederhana yang sangatmembantudalammenegakkan diagnosis efusi pleura dan berperandalammelakukaneksplorasietiologi dan prognosis penyakit. Oleh karenaitu, semuakelainanefusi pleura yang belumterdiagnosissebaiknyadilakukanpemeriksaansitologiuntuk diagnosis awal dan manajemenpasienselanjutnya.

Nasal Associated Lymphoma Tumors Reno Keumalazia Kamarlis; Vera Dewi Mulia; Benny Kurnia
Budapest International Research in Exact Sciences (BirEx) Journal Vol 2, No 3 (2020): Budapest International Research in Exact Sciences, July
Publisher : Budapest International Research and Critics University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33258/birex.v2i3.1062

This study analyses nasal associated lymphoma tumors, the results of histopathological examination obtained a picture that supports the establishment of a diffuse large B-cell lymphoma (DLBCL) with the characteristics of typical cells. This patient does not support an extranodal NK / T nasal lymphoma type cell because there are no glandular mucosa and clear cell peculiar changes as well as areas that experience necrosis, vascular destruction and fibrinoid deposits in blood vessel walls

CHARACTERISTIC OF NASOPHARYNGEAL CARSINOMA IN ACEH 2016-2017 Benny Kurnia; Reno Keumalazia Kamarlis; Fera Kamila Kamal
INTERNATIONAL JOURNAL OF NASOPHARYNGEAL CARCINOMA Vol. 1 No. 01 (2019): International Journal of Nasopharyngeal Carcinoma
Publisher : TALENTA PUBLISHER

Introduction Nasopharyngeal carcinoma is among five major malignancies in Indonesia and the primary malignant tumor in men. Among all head and neck (H&N) cancers, nasopharyngeal carcinoma (NPC) is endemic in certain regions of the world, especially in Southeast Asia, and has a poor prognosis. In Indonesia, the recorded mean prevalence is 13 000 yearly new NPC cases, but otherwise little is documented on NPC in Indonesia. Objectives We collected all cases of nasopharyngeal carcinoma diagnosed by histopathological examination during the period of 2016-2017 from archives of the registry in the Ear, Nose, and Throat department and Patologi Anatomy laboratory Dr. Zainoel Abidin General Hospital. We did this research to presenting the basic data of NPC in Aceh according to gender, age, geographic site and WHO histopathology criteria. Method All the data we counted by using Microsoft Excel 2016 by grouping it according to the variable that we want to grade. We made it into a table and graphic presentation to explain each item of the variable. Result Here, in Aceh, we reported 46 cases in the year 2016 and 26 cases in the year 2017, a total of 72 patients during 2 years. We studied NPC incidence in Aceh among all H&N cancer cases focusing on age, gender, the ethnic background, and the disease histopathology. In this study population, from a total of 72 patient we found 44 male (61.1%) and 28 female (38.9%), with a male to female ratio is 1.57:1. According to the geographic site, NPC in Aceh was the most endemic in the Banda Aceh population (15.3%) followed by Southwest Aceh (12.5%) as a second one. From the age range, NPC most frequent to affect patients at the age range 41-60 years (44.44%), besides that we found 8 (11.11%) cases NPC in Aceh at the age 0- 20 years with 13 years old patient was the younger one. Here, we found that Undifferentiated NPC is the most frequent histological type (44.4%). We continued the study by analyzed NPC patient according to WHO criteria, type I WHO most frequent from the Great Aceh. Type II and Type III WHO we found most frequent from Banda Aceh. Conclusion: Our data NPC incidence did not differ significantly among the literature. Mostly NPC patients over the world at the old adult age, even all of the age range can be affected by NPC. There are similar histopathological features results here compare to the Southeast Asian country.

GROWTH INHIBITION AND INDUCTION OF APOPTOSIS IN MCF-7 AND T47D BREAST CANCER CELL LINES BY ETHANOL EXTRACT OF SEURAPOH (Chromolaena odorata) LEAVES Hanifah Yusuf; Reno Keumalazia Kamarlis; Yusni Yusni
Jurnal Kedokteran Hewan Vol 14, No 3 (2020): September
Publisher : Universitas Syiah Kuala

This study aims to determine the growth inhibition and apoptosis induction of MCF-7 and T47D cancer cells by ethanol extract of Chromolaena odorata leaves. A post-test with control group design was used in this study. The extract was made by maceration with 80%ethanol and the tested concentrations used were 7.80 µg/mL-500 µg/mL with standard drug doxorubicin ranged from 1.56 µg/mL-100 µg/mL.The growth inhibition was determined by the MTT colorimetry method, apoptosis induction by double staining using acridine orange-ethidiumbromide, and the existence of apoptosis was proven immunocytochemically through the expression of Bcl-2 proteins. The results showed that the growth inhibition of MCF-7 was 100.29%-28.19% and T47D was 100.37%-16.01%. The IC50 values of MCF-7 was 327.34 µg/mL and T47D was 135.16 µg/mL. The presence of apoptosis was marked by finding the morphological change of cells such as dead, necrosis, and chromatin condensation cells. This suggests that interventions with ethanol extract of Chromolaena odorata leaves can induce apoptosis that has been proven by reducing the expression of Bcl-2 proteins.

GROWTH INHIBITION AND INDUCTION OF APOPTOSIS IN MCF-7 AND T47D BREAST CANCER CELL LINES BY ETHANOL EXTRACT OF SEURAPOH (Chromolaena odorata) LEAVES Hanifah Yusuf; Reno Keumalazia Kamarlis; Yusni Yusni
Jurnal Kedokteran Hewan Vol 14, No 3 (2020): September
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21157/j.ked.hewan.v14i3.17227

This study aims to determine the growth inhibition and apoptosis induction of MCF-7 and T47D cancer cells by ethanol extract of Chromolaena odorata leaves. A post-test with control group design was used in this study. The extract was made by maceration with 80%ethanol and the tested concentrations used were 7.80 µg/mL-500 µg/mL with standard drug doxorubicin ranged from 1.56 µg/mL-100 µg/mL.The growth inhibition was determined by the MTT colorimetry method, apoptosis induction by double staining using acridine orange-ethidiumbromide, and the existence of apoptosis was proven immunocytochemically through the expression of Bcl-2 proteins. The results showed that the growth inhibition of MCF-7 was 100.29%-28.19% and T47D was 100.37%-16.01%. The IC50 values of MCF-7 was 327.34 µg/mL and T47D was 135.16 µg/mL. The presence of apoptosis was marked by finding the morphological change of cells such as dead, necrosis, and chromatin condensation cells. This suggests that interventions with ethanol extract of Chromolaena odorata leaves can induce apoptosis that has been proven by reducing the expression of Bcl-2 proteins.

Chronic cutaneous chromoblastomycosis: A rare case Earlia, Nanda; Maulida, Mimi; Handriani, Risna; Kamarlis, Reno Keumalazia; Pradistha, Aldilla
Journal of General - Procedural Dermatology & Venereology Indonesia Vol. 8, No. 1
Publisher : UI Scholars Hub

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Background: Chromoblastomycosis (CBM) is a rare, chronic granulomatous and suppurative skin infection classified as a subcutaneous mycosis. CBM has a poor prognosis with a low cure rate and a high recurrence rate. The lack of scientific data regarding the diagnosis and treatment of CBM also presents a challenge for clinicians in treating this disease. Appropriate therapy can increase the cure rate and prevent disease recurrence. Case Illustration: A 66-year-old woman presented with swelling in her left arm since the last 18 years due to wood-related injuries. There were multiple well-defined hyperkeratotic verrucous plaques, papules, and nodules, measuring 6-10 cm in diameter on the left antebrachial and hand regions. Some lesions were covered with erosion and crusts. The patient also had bone malformation. Histopathological examination showed typical characteristics of CBM. The patient was treated with 100 mg Itraconazole b.i.d. for 8 months. Discussion: Clinical manifestations and histopathological examination showed typical characteristics of CBM. Bone malformation occurred due to complications in chronic cases. Facility limitations led to the inability to perform direct microscopic examination using potassium hydroxide (KOH) and fungal culture on Sabouraud's dextrose agar. After 8 weeks of treatment, the patient's lesions were improved. The patient will be evaluated every month until treatment is complete to monitor the side effects of therapy. Conclusion: CBM lesions were improved after 8 weeks of treatment. Bone malformation could occur in chronic cases. It is important to diagnose CBM correctly and provide adequate therapy for a good outcome.

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