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HUBUNGAN POLIMORFISME GEN CATECHOL-O-METHYLTRANSFERASE (COMT) VAL158MET DENGAN KEJADIAN MIOMA UTERI PADA ETNIS MELAYU DI SUMATERA SELATAN Precelia Fransiska; Ferry Yusrizal; Legiran Legiran
Jurnal Kedokteran Syiah Kuala Vol 18, No 3 (2018): Volume 18 Nomor 3 Desember 2018
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24815/jks.v18i3.18014

Abstrak. Objektif : Untuk mengetahui distribusi karakteristik sosiodemografi, genotip dan alel polimorfisme gen Catechol-O-Methyltransferase (COMT) Val158Met dengan kejadian mioma uteri pada etnis Melayu di Sumatera Selatan. Desain Penelitian : Penelitian ini merupakan analitik observasional dengan desain kasus kontrol (case-control). Penelitian ini dilaksanakan pada bulan November 2018-Januari 2019 dilaboratorium bioteknologi fakultas kedokteran universitas sriwijaya. Sampel penelitian menggunakan sampel darah yang diambil pada 78 sampel yang terdiri dari 39 kasus dan 39 kontrol yang dilakukan dengan metode PCR RFLP. Hasil : Usia, usia saat menarche, riwayat keluarga dan merokok tidak terdapat hubungan yang bermakna sedangkan paritas dan menggunakan kontrasepsi hormonal memiliki hubungan yang bermakna. Genotip positif mioma terdapat 17 responden dan negatif mioma 1 responden dari 78 responden untuk alel guanin terdapat 33 responden dan alel adenin 3 responden. Kesimpulan : Tidak terdapat perbedaan hubungan antara gen Catechol-O-Methyltransferase (COMT) Val158Met dengan kejadian mioma uteri pada etnis Melayu di Sumatera Selatan dikarenakan hasil dari PCR dan RLFP hanya terdapat pemotongan sebanyak 18 responden dari 78 responden sehingga tidak dapat dianalisis menggunakan SPSS karena tidak memenuhi persyaratan uji statistik akan tetapi gen Catechol-O-Methyltransferase (COMT) Val158Met merupakan faktor risiko untuk terjadinya mioma uteri. Kata Kunci: Mioma uteri, Polimorfisme, gen Catechol-O-Methyltransferase (COMT) Val158met Abstract. Objective: to determine the characteristic distribution of sociodemography, genotypes and the polymorphism allele of the Catechol-O-Methyltransferase (COMT) Val158met gene with the incidence of uterine myoma in Malay ethnicity in South Sumatra. Intervention: This study is an observational analytic with case-control design (case-control). This research was conducted in November 2018-January 2019 in the laboratory of molecular biology at the Sriwijaya University medical school. The study sample used blood samples taken in 78 samples consisting of 39 cases and 39 controls carried out by the RFLP PCR method. Results: age, age at menarche, family history and smoking had no significant relationship while parity and hormonal contraception had a significant relationship. Positive myoma genotypes were 17 respondents and negative myoma 1 respondent from 78 respondents for the guanin allele there were 33 respondents and adenin alleles 3 respondents. Conclusion: there is no difference between the relationship between the Catechol-O-Methyltransferase (COMT) Val158met gene and the incidence of uterine myoma in Malay ethnicity in South Sumatra because the results of PCR and RLFP were only 18 respondents from 78 respondents so they could not be analyzed using SPSS because they did not meeting statistical test requirements but the Catechol-O-Methyltransferase (COMT) Val158met gene is a risk factor for the development of uterine myomas.Keywords: uterine myoma, Polymorphism, Catechol-O-Methyltransferase (COMT) Val158met

Hubungan Antara Pengetahuan dan Status Gizi Ibu Hamil dengan Kejadian Pre Eklamsia pada Ibu Hamil Precelia Fransiska
Citra Delima : Jurnal Ilmiah STIKES Citra Delima Bangka Belitung Vol 4 No 1 (2020): Citra Delima: Jurnal Ilmiah STIKES Citra Delima Bangka Belitung
Publisher : STIKES Citra Delima Bangka Belitung

Pre eclamsia every pregnant women Indonesia is prone to hypertension,wich is caused for 48 hours,during preganancy. The purpose this study was to determine is relationship between knowledge, and nutritional status the pregnant women with the incidence of pre-eclampsia, The women pregnant in Prabumulih Country Health Center in 2019. This study uses analytical survey using the cross sectional approach. The population of this were pregnant women who had preeclampsia at Prabumulih country, Health Center. This method take with by doing a test on pregnant women,from the results of research and analysis univariately, from 58 people with detail,36 (62,1%) people with good knowledge, and 20 (34,5%) people not good. From the results above to 29 (50%) people well also nutrished are, and 29 people nutrition have poor. Bivariate analysis showed that Knowledge had a significant relationship with pre-eclampsia (p value 0.006) and Nutritional Status had a significant relationship with the incidence of pre-eclampsia (p value 0.006). The conclusion of this study is that there is a relationship between knowledge and nutritional status of pregnant women with the incidence of pre-eclampsia in pregnant women in the Prabumulih Coutry Health Center 2019.

Hubungan Antara Pengetahuan dan Status Gizi Ibu Hamil dengan Kejadian Pre Eklamsia pada Ibu Hamil Precelia Fransiska
Citra Delima Scientific journal of Citra Internasional Institute Vol 4 No 1 (2020): Citra Delima: Jurnal Ilmiah STIKES Citra Delima Bangka Belitung
Publisher : Ilmiah Institut Citra Internasional

Pre eclamsia every pregnant women Indonesia is prone to hypertension,wich is caused for 48 hours,during preganancy. The purpose this study was to determine is relationship between knowledge, and nutritional status the pregnant women with the incidence of pre-eclampsia, The women pregnant in Prabumulih Country Health Center in 2019. This study uses analytical survey using the cross sectional approach. The population of this were pregnant women who had preeclampsia at Prabumulih country, Health Center. This method take with by doing a test on pregnant women,from the results of research and analysis univariately, from 58 people with detail,36 (62,1%) people with good knowledge, and 20 (34,5%) people not good. From the results above to 29 (50%) people well also nutrished are, and 29 people nutrition have poor. Bivariate analysis showed that Knowledge had a significant relationship with pre-eclampsia (p value 0.006) and Nutritional Status had a significant relationship with the incidence of pre-eclampsia (p value 0.006). The conclusion of this study is that there is a relationship between knowledge and nutritional status of pregnant women with the incidence of pre-eclampsia in pregnant women in the Prabumulih Coutry Health Center 2019.

FAKTOR-FAKTOR YANG MEMPENGARUHI PEMERIKSAAN PAYUDARA SENDIRI (SADARI) PADA SISWI KELAS XI DI SMK PELITA INSANI KOTA PRABUMULIH Dwi Saputri MS; Precelia Fransiska
Jurnal Kesehatan dan Pembangunan Vol 14 No 2 (2024): Jurnal Kesehatan dan Pembangunan
Publisher : LPPM STIKes Mitra Adiguna

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52047/jkp.v14i2.343

Breast self-examination (BSE) is an early detection effort to prevent breast cancer. This BSE activity is carried out by someone to examine and find out any changes in their breasts. The aim of the research is to find out the factors that influence breast self-examination (BSE) in class Cross Sectional. The population of this study were female students in class The research instrument is a questionnaire. The results of the research based on univariate analysis showed that of the 55 respondents there were 41 respondents (74.5%) who had BSE examinations and 14 respondents (25.5%) who had not carried out BSE examinations, there were 37 people (67.3%) who had knowledge good and 18 people (32.7%) who had poor knowledge, there were 9 people (16.4%) who had a family history of breast cancer and 46 people (83.6%) who had no family history of breast cancer, there were 45 people (81.8%) had a normal age at menarche and 10 people (18.2%) had an abnormal age at menarche. From the bivariate analysis there is a significant relationship between knowledge and BSE examination with a P value of 0.000 < ? 0.05, there is a significant relationship between family history and BSE examination with a P value of 0.000 < 0.05. There is a significant relationship between age at menarche and BSE examination with a P value of 0.000 < 0.05. It is hoped that this BSE examination will be used as part of the health education that must be given to obstetrics clinics so that they can disseminate information about early detection of ca mammae disease.

HUBUNGAN TINGKAT PENGETAHUAN DAN SIKAP IBU TERHADAP TINDAKAN MENCUCI TANGAN DALAM PERAWATAN TALI PUSAT Precelia Fransiska; Rahmi Febriana
Jurnal Ilmu Kebidanan dan Kesehatan (Journal of Midwifery Science and Health) Vol. 16 No. 01 (2025): Jurnal Ilmu Kebidanan dan Kesehatan (Journal of Midwifery Science and Health)
Publisher : Sekolah Tinggi Ilmu Kesehatan Bakti Utama Pati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52299/jks.v16i01.401

Perawatan tali pusat pada bayi baru lahir yang benar adalah perawatan tali pusat yang selalu memperhatikan kebersihan dan kesterilan tali pusat. Tujuan penelitian adalah untuk mengetahui hubungan tingkat pengetahuan dan sikap ibu terhadap tindakan mencuci tangan dalam perawatan tali pusat di PMB Umi Kalsum Kota Prabumulih tahun 2024. Metode penelitian bersifat analitik, dengan mengunakan pendekatan Cross Sectional. Populasi penelitian ini adalah seluruh ibu bersalin yang berkunjung di PMB Umi Kalsum saat melakukan penelitian bulan Maret tahun 2024. Pengambilan sampel pada penelitian ini menggunakan metode teknik Accidental Sampling yaitu sebanyak 45 orang. Instrumen penelitian berupa kuesioner. Hasil penelitian berdasarkan analisa bivariat diketahui bahwa dari 33 responden yang memilliki pengetahuan baik terdapat 30 orang (66,7%) melakukan tindakan cuci tangan sebelum melakukan perawatan tali pusat sedangkan dari 12 responden yang memiliki pengetahuan kurang terdapat 5 responden (11,1%) melakukan tindakan cuci tangan sebelum melakukan perawatan tali pusat. Dari 37 responden yang memiliki sikap mendukung terdapat 33 orang (73,3%) yang melakukan tindakan cuci tangan sebelum melakukan perawatan tali pusat sedangkan dari 8 responden yang memiliki sikap tidak mendukung terdapat 2 orang (4,4%) melakukan tindakan cuci tangan sebelum melakukan perawatan tali pusat. Simpulan ada hubungan yang bermakna antara pengetahuan dengan tindakan cuci tangan sebelum melakukan perawatan tali pusat dengan nilai Pvalue 0,002< ? 0,05 dan ada hubungan yang bermakna antara sikap ibu dengan tindakan cuci tangan sebelum melakukan perawatan tali pusat dengan nilai Pvalue 0,000< ? 0,05.

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