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All Journal Amerta Nutrition World Nutrition Journal JITSI : Jurnal Ilmiah Teknologi Sistem Informasi The Indonesian Journal of Community and Occupational Medicine Occupational and Environmental Medicine Journal of Indonesia Journal of Indonesian Specialized Nutrition Ophthalmologica Indonesiana Kesmas: Jurnal Kesehatan Masyarakat Nasional (National Public Health Journal)
Levina Chandra Khoe
Department Of Community Medicine, Faculty Of Medicine, Universitas Indonesia
Computer Science & IT Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Other

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Caesarean delivery mode and its impact on children’s growth and cognitive development Rini Sekartini; Levina Chandra Khoe
World Nutrition Journal Vol. 4 No. S2 (2020)
Publisher : Indonesian Nutrition Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25220/WNJ.V04.S2.0004

Abstract

There is an increasing concern on the potential risk of Caesarean birth on child health outcomes. This study aims to present the current available evidences on the effect of Caesarean section on child’s growth and development. Literature searching were done on several online databases to identify articles which discussed the effect of Caesarean birth on child’s body weight, length, nutritional status, cognitive development, memory, learning ability, and intelligence quotient. Several studies showed positive association between Caesarean and risk of overweight and obesity in childhood, adolescence, and adulthood. While, there has not been sufficient evidences to confirm the association between C-section and child’s cognitive outcomes.
The impact of Caesarean delivery mode towards brain and neurodevelopment among children Tjhin Wiguna; Levina Chandra Khoe
World Nutrition Journal Vol. 4 No. S2 (2020)
Publisher : Indonesian Nutrition Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25220/WNJ.V04.S2.0005

Abstract

In regards to the rising rate of Caesarean birth globally, there is concern about the risk of Caesarean birth in children. However, the effect of Caesarean delivery towards the child brain and neurodevelopment is not well understood. We reviewed articles from online database with topics related to the relation between caesarean delivery mode and brain development/neurodevelopment/behaviour and emotional development. Several studies discussed how birth mode could affect brain structural connectivity through neural and hormone changes. Some studies also assessed possible effect on child’s psychological development.  The result showed differences in child’s brain development between caesarean and natural delivery in the early life, but not in the long run. Additionally, no significant association between birth mode and emotional problem.
Immune development of children born from Caesarean section Zakiudin Munasir; Levina Chandra Khoe
World Nutrition Journal Vol. 4 No. S2 (2020)
Publisher : Indonesian Nutrition Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25220/WNJ.V04.S2.0003

Abstract

Several studies results have shown that mode of delivery affects the health of children, and recent studies showed that elective cesarean section (CS) is associated with aberrant short-term immune responses in the newborn baby and an increased risk of developing immune disorders. This article focused on the effect and role of the C-section on the immune development in children. Begin at pregnancy, the infant's immune system is activated and develops years after birth. In this article we find that cesarean delivery mode will influence the offspring's immune system by disrupting the intestinal tract's bacterial colonization, different levels of birth adaptive stress, and altering gene expression epigenetic regulation. Some studies have found that gut microbiome composition plays a significant role in the development of immune system along with other factors such as diet/lifestyle, antibiotic use, formula feeding, vaccination with life vaccine, and pathogen exposure. In early life, disrupted colonization induced dysbiosis that was associated with lower Bifidobacteria and higher counts of C. difficile. These findings are related to infant immune disease and allergy. Dysbiosis following C-section has a huge effect of developing altered immune system, and this microbiome imbalance can be controlled by nutritional support such as maternal breast milk or the use of different combinations of prebiotics and probiotics (synbiotic) which could be beneficial for the immune and metabolic system.
Strengthening Community Program toward Healthy Ageing: What are the Potential Interventions? Endang Mariani Rahayu; Nuri Purwito Adi; Levina Chandra Khoe
Amerta Nutrition Vol. 4 No. 1SP (2020): AMERTA NUTRITION SUPPLEMENTARY EDITION
Publisher : Universitas Airlangga, Kampus C, Mulyorejo, Surabaya-60115, East Java, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/amnt.v4i1SP.2020.6-9

Abstract

Background: The number of elderly populations is increasing each year. As the number of elderly populations increases, the risk of non-communicable diseases, such as hypertension, diabetes, stroke, will also increase. The main risk factors for this disease include unhealthy diet, inadequate physical activity, smoking, inadequate rest, frequent stress and etc., which are considered as individual's lifestyle. This lifestyle starts when the individual grows up. Therefore, health interventions must be carried out since the individual turns to adulthood in order to prepare themselves for healthy ageing.Purpose: This study aimed to review the conceptual framework necessary to develop public health programs in preparation for healthy aging.Discussion: In the preparation for healthy ageing, health interventions should be conducted by targeting the adult population. The health interventions should be based on the theory of behavior change, life-course approach, and ecological approach. In addition, with the advancement of technology, the health interventions can also be carried out by involving digital intervention. The contextual elements, such as social, cultural and psychological context are also important in implementing the program so that it can be accepted by the targeted community.Conclusion: There is no intervention that fits all levels of society. Therefore, the interventions must be developed specifically for the population according to the local context.
Parkinson’s in Farmers, Could it be Caused by the Paraquat Herbicide Exposure? Arriz Akbar Sukadi; Dewi Yunia Fitriani; Levina Chandra Khoe
The Indonesian Journal of Community and Occupational Medicine Vol. 2 No. 1 (2022): ijcom
Publisher : ILUNI MKK FKUI and PRODI MKK FKUI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53773/ijcom.v2i1.44.58-65

Abstract

Many studies have been carried out to assess the safety of the widespread use of pesticides in agriculture with diseases in farmers. A 52-year-old female farmer suffered Parkinson’s after working 27 years using paraquat herbicide. This study was conducted to obtain answers about the impact of paraquat exposure on the incidence of Parkinson’s in farmers through evidence-based case reports (EBCR) derived from a literature review.The review was conducted through the search and selection method of articles in PubMed, ProQuest, and Cochrane Library to answer research questions. The article search process used the keywords “paraquat AND Parkinson AND farmer”. Article selection was carried out using predetermined inclusion and exclusion criteria. In the initial search, 35 articles were retrieved and through the selection process three articles of the meta-analysis systematic review were selected.Selected articles from Tangamornsuksan and Vaccari show a statistically significant association between paraquat exposure and the incidence of Parkinson’s disease (PD) in workers, with a pooled OR of 1.70 and 1.24. Meanwhile, Yan’s study shows that duration of exposure to pesticides increases the risk of PD. The result showed a 5 and 10 years of duration exposure to pesticide were associated with a 5% and 11% augment in the risk of PD. All studies applied validation to reduce bias and heterogeneity effects or inadequate statistical methods.Based on the results of this evidence-based case report, it shows that the epidemiological studies taken can prove the possibility that Parkinson’s disease in this farmer is caused by exposure to paraquat.
Factors Associated with The Length of Sick Leave Due to Covid-19 Betharia Sonata Butarbutar; Nuri Purwito Adi; Levina Chandra Khoe; Marsen Isbayu Putra; Aria Kekalih
The Indonesian Journal of Community and Occupational Medicine Vol. 2 No. 1 (2022): ijcom
Publisher : ILUNI MKK FKUI and PRODI MKK FKUI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53773/ijcom.v2i1.49.11-6

Abstract

Background: Despite the COVID-19 pandemic, the workers in food manufacturing continue to work. The Government of Indonesia issued a regulation of 10-day isolation for those asymptomatic patients. This regulation implies long sick leave for workers with asymptomatic COVID-19 infection, leading to possible disruption in fulfilling target production. This study aims to understand the factors associated with the length of sick leave due to COVID-19 among food manufacturing workers. Methods: The design of this study was cross-sectional, used 205 workers’ data of confirmed COVID-19 infection, and returned to work from March 2020 – to August 2021. The data were obtained by the company medical team from medical resumes at the companies’ clinics and then sent to Ikatan Dokter Kesehatan Kerja Indonesia (IDKI) Banten. The data was screened as inclusion and exclusion criteria and then analyzed by descriptive test. unpaired T-test and linear regression. Results: The mean length of sick leave of 205 data was 19.3 (± 4,8) days. Treatment facilities, work shifts, and smoking were associated with the length of sick leave (p<0.05). Home Self-isolating, shift, and non-smoking workers had longer sick leave than workers treated at COVID center, non-shift, and smoking workers Conclusion: The mean length of sick leave among food workers in Cilegon is 19.3 (±4,8) days. There is a significant relationship between the length of sick leave with treatment facilities, shift work, and smoking. Treatment facilities were the most dominant factor.
Overview of Glycemic Control in Workers with Diabetes at An Occupational Clinic in Jakarta Edwin Halim; Em Yunir; Amilya Agustina; Astrid Sulistomo; Levina Chandra Khoe
The Indonesian Journal of Community and Occupational Medicine Vol. 3 No. 1 (2023): ijcom
Publisher : ILUNI MKK FKUI and PRODI MKK FKUI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53773/ijcom.v3i1.72.17-23

Abstract

Introduction: Based on Indonesia’s population data in 2018 and International Diabetes Federation in 2019, an estimated 1 in every 10 Indonesian workers have type 2 diabetes mellitus (T2DM). Diabetes is a chronic illness with costly implications, especially in working population. Workers with diabetes experience 12% reduction in productivity adjusted life years (PALY) and additional $USD 467 monthly average healthcare cost. This study aims to determine glycaemic control in workers with diabetes.Methods: Cross-sectional study utilizing laboratory medical records from 2015-2021 in an occupational clinic in Jakarta’s Central Business District is performed. Data collected through accessing in-clinic laboratory and client lists’ electronic medical records, is paired with their respective anthropometric parameters stored in paper archives. Criteria of Fasting Blood Glucose (FBG), lipid profile, HbA1c and Body Mass Index (BMI) are based on PERKENI 2019. Inclusion criteria are workers with prior history of T2DM who underwent HbA1c examination.Results: 2,796 employees who underwent HbA1c examination were found; 65.8% normal, 29.6% pre-diabetic, and 4.6% exceeded T2DM cut-off. Amongst 2,796 employees, 1,322 had their FBG examined; 62% normal, 33.1% had increased fasting glucose and 5% exceeded T2DM cut-off; another 1,316 also had their lipid profile examined, in which 80.5% had dyslipidaemia. From 2015-2021, 160 employees had a history of T2DM, of which 86 had matching laboratory medical records, with 42 of those undergoing HbA1c examination. Of 42 respondents with diabetes who underwent HbA1c examinations, 54.8% had sub-optimal glycaemic control. FBG is the only risk factor significantly correlated to optimal glycaemic control (p <0.05).Conclusion: Health programs and policies in the workplace enacted by management and health institutions who offer medical services may play a vital role in the improvement of prevention and intervention of diabetes amongst workers.
Validation of Indonesian Graves’ Ophthalmopathy Quality of Life Questionnaire and Its Association with Clinical Activity and Severity of Graves’ Ophthalmopathy CECILIA ANGGRAINI; Syntia Nusanti; Muhammad Sidik; Dicky L Tahapary; Levina Chandra Khoe
Majalah Oftalmologi Indonesia Vol 49 No S2 (2023): Supplement Edition
Publisher : The Indonesian Ophthalmologists Association (IOA, Perhimpunan Dokter Spesialis Mata Indonesia (Perdami))

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35749/v3z1dc46

Abstract

Abstract Introduction & Objectives : Graves' ophthalmopathy (GO) ocular abnormalities persisted even after treatment, negatively impacting the patient's psychological and social health. The Indonesian Graves' Ophthalmopathy Quality of Life (GO-QoL) Questionnaire has not been validated; hence it cannot measure patient quality of life in Indonesia, which is crucial to GO treatment. This objective of this study is providinga reliable Indonesian GO-QoL questionnaire and identifying an association between patient quality of life and clinical activity and severity of GO. Methods : The cross-sectional study ran from May through October 2022. Graves' ophthalmopathy and thyroid disease management were the inclusion criteria. Those who could not be reached by video call or controlled for two weeks for test-retest data collection were excluded. The process of questionnaire validation involves transcultural adaptation and cross-sectional design. The content validity index (CVI) and Cronbach's alpha assessed validity and reliability, respectively. Results : Content validity index (CVI) was 1.00 for the Indonesian GO-QoL questionnaire. Cronbach's alpha visual function subscale value was 0.971, while the appearance subscale value was 0.993, and the total score was 0.986. The appearance subscale and total score of GO patients' quality of life had a significant association with the clinical activity score (p<0.05) and disease severity (p<0.001). Conclusion : The Indonesian version of the GO-QoL questionnaire has high validity and reliability values. Patients' appearance and overall quality of life decreases with active Graves' ophthalmopathy. Graves' ophthalmopathy severity decreases quality of life on the appearance and overall subscales.
Validity and Reliability of Farra Eye Model as a Surgical Simulator for Capsulorhexis Training: Oral Presentation - Observational Study - Resident HANIFAH RAHMANI NURSANTI; Julie Dewi Barliana; Syska Widyawati; Faraby Martha; Levina Chandra Khoe
Majalah Oftalmologi Indonesia Vol 49 No S2 (2023): Supplement Edition
Publisher : The Indonesian Ophthalmologists Association (IOA, Perhimpunan Dokter Spesialis Mata Indonesia (Perdami))

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35749/w12r3545

Abstract

Abstract Introduction & Objectives : Various simulation models are available for cataract surgery training. Farra Eye Model, a new cataract surgery simulator, was developed to provide the resident with more affordable options. This study aims to determine the validity and reliability of the Farra Eye Model as a surgical simulator for capsulorhexis training. Methods : A cross-sectional pilot study was performed among ophthalmology residents and consultants to assess face, content, and construct validity of a new surgical simulator. Subjects were divided into novice, intermediate, and expert groups according to their level of expertise. Face and content validity was assessed using a validated questionnaire with a 5-point Likert scale response. Construct validity was done by comparing capsulorhexis performance between the three groups. Two raters assessed performance using capsulorhexis indices in ICO-OSCAR: Phaco assessment tool, number of forceps grabs, and duration of capsulorhexis. Results : A total of 33 subjects were recruited and divided equally into three groups. The overall face validity score was favorable (3.67 ± 0.67). However, the capsule elasticity was rated poor (2.73 ± 1.1) among the intermediate group. The content validity was favorable regarding the overall score (4.15± 0.58) and each assessment component. In the construct validity test, intermediate and expert groups showed better capsulorhexis performance than the novice group on all parameters (p<0.001), with good inter-rater reliability (ICC>0.7). Conclusion : Farra Eye Model has a good face and content validity for capsulorhexis training and is able to differentiate the novice group from intermediate and expert groups. However, it remains a challenge to replicate human lens capsule elasticity.
Soy Formula as An Alternative for Infants with Cow’s Milk Allergy: Perspective from Pediatricians and Midwives in Indonesia Chandra Khoe, Levina; Sitorus, Nova
Journal of Indonesian Specialized Nutrition Vol. 1 No. 1 (2023): Journal of Indonesian Specialized Nutrition
Publisher : Ridwan Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46799/jisn.v1i1.4

Abstract

The prevalence of food allergy in children is increasing globally, with cow's milk allergy beingthe most common in infants and increasing from 2% to 3% in developed countries. However, data oncow's milk allergy in infants is limited in Indonesia. This study used a mixed methods approach using anonline survey and in-depth interviews. The survey was conducted from September 2021 to March 2022.Qualitative analysis, all interviews were recorded and transcribed. Data were analyzed using simplethematic analysis. The results showed that a total of 93 pediatricians and 104 midwives participated inthe survey. However, among the 93 pediatricians, only 56 (60.2%) completed the survey. Meanwhile, 11midwives (10.6%) were excluded because they had no experience in handling CMA cases. The majorityof CMA cases occurred in children under two years old, and most were treated by pediatricians. In termsof diagnostic tests, 51.8% of pediatricians recommended all specific IgE tests, prick tests, and provocationtests to diagnose allergies. More than 80% (46/56) of pediatricians chose to avoid all types of cow's milkproducts in the mother and child's diet as the main treatment. Meanwhile, only 22.1% of midwives didthe same. Milk choice will differ depending on the severity of CMA. Soy milk formula is preferred bymidwives for patients with low-level and moderate to severe allergies. Meanwhile, pediatriciansrecommend extensive hydrolysate formula for low severity patients and amino acid-based formula formoderate to severe.
Co-Authors Agiananda, Feranindhya Agus Sugiharto Amilya Agustina Aria Kekalih Arifianto, Angga Arriz Akbar Sukadi Astrid Sulistomo Atika, Nur Betharia Sonata Butarbutar CECILIA ANGGRAINI Dani Muhamad Trianto Dewi Sumaryani Soemarko Dewi Yunia Fitriani Dicky L Tahapary Djatikusumo, Ari Edwin Halim Em Yunir, Em Endang Mariani Rahayu Faraby Martha Fitria Nurbaeti HANIFAH RAHMANI NURSANTI Herqutanto - Imron Khazim Indah S. Widyahening Julie Dewi Barliana Marsen Isbayu Putra Martha Landauw Mokoagow, M. Ikhsan Muhammad Aji Muharrom Muhammad Ilyas Muhammad Sidik Nuri Purwito Adi Nuri Purwito Adi Pertiwi, Dhia Ticha Pramastuty, Ajeng putri, septiara Retno Asti Werdhani Reza Haryo Yudanto Rini Sekartini Sabarguna, Boy Subirosa Sitorus, Nova Syntia Nusanti Syska Widyawati Tanoto, Rodri Tjhin Wiguna UTAMI, ALIA NESSA Zakiudin Munasir